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Dbn1 drebrin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81653, updated on 5-Sep-2021

Summary

Official Symbol
Dbn1provided by RGD
Official Full Name
drebrin 1provided by RGD
Primary source
RGD:70885
See related
Ensembl:ENSRNOG00000014170
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may play a role in neurite outgrowth [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 91.3), Heart (RPKM 46.8) and 9 other tissues See more
Orthologs
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Genomic context

See Dbn1 in Genome Data Viewer
Location:
17p14
Exon count:
16
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9150608..9164982)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9679511..9693878)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene docking protein 3 Neighboring gene PDZ and LIM domain 7 Neighboring gene proline rich 7 (synaptic) Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene coagulation factor XII

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cytoskeletal motor inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables profilin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell communication by chemical coupling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell communication by chemical coupling ISO
Inferred from Sequence Orthology
more info
 
involved_in cell communication by electrical coupling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytoplasmic sequestering of protein IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic sequestering of protein ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within generation of neurons ISO
Inferred from Sequence Orthology
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in lung alveolus development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in maintenance of protein location in cell IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within maintenance of protein location in cell ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of muscle filament sliding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor localization to synapse IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor localization to synapse ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in postsynaptic actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic density protein 95 clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonal spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in gap junction IEA
Inferred from Electronic Annotation
more info
 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
drebrin
Names
developmentally-regulated brain protein
drebrin E

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031024.2NP_112286.1  drebrin

    See identical proteins and their annotated locations for NP_112286.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000284
    UniProtKB/Swiss-Prot
    Q07266
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    9150608..9164982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253655.4XP_006253717.1  drebrin isoform X1

    See identical proteins and their annotated locations for XP_006253717.1

    UniProtKB/TrEMBL
    A0A0H2UHL9
    Related
    ENSRNOP00000019569.4
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  2. XM_006253656.4XP_006253718.1  drebrin isoform X2

    See identical proteins and their annotated locations for XP_006253718.1

    UniProtKB/TrEMBL
    C6L8E0
    Related
    ENSRNOP00000019393.2
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  3. XM_006253657.4XP_006253719.1  drebrin isoform X3

    See identical proteins and their annotated locations for XP_006253719.1

    UniProtKB/Swiss-Prot
    Q07266
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  4. XM_008771507.3XP_008769729.1  drebrin isoform X4

    Conserved Domains (1) summary
    cd11281
    Location:26135
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
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