UBA1 ubiquitin-activating enzyme 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: UBA1
Gene description: ubiquitin-activating enzyme 1
Primary source: Araport:AT2G30110
Locus tag: AT2G30110
See related: TAIR:AT2G30110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATUBA1; MODIFIER OF SNC1 5; MOS5; T27E13.15; T27E13_15; ubiquitin-activating enzyme 1
Summary: Encodes a ubiquitin-activating enzyme (E1), involved in the first step in conjugating multiple ubiquitins to proteins targeted for degradation. Gene is expressed in most tissues examined. Mutant is able to revert the constitutive defense responses phenotype of snc1, which indicates the gene is involved in defense response. It also indicates that ubiquitination plays a role in plant defense signalling.
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Genomic context

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See UBA1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 7

Sequence:: Chromosome: 2; NC_003071.7 (12852329..12857727, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

One mutant that suppresses snc1-mediated constitutive resistance is modifier of snc1 5 (mos5), which carries a 15-bp deletion in the C-terminus of UBA1.
Title: The ubiquitin pathway is required for innate immunity in Arabidopsis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_128566.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ubiquitin activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin activating enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to other organism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in peroxisome	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: ubiquitin-activating enzyme 1

NP_565693.1

ubiquitin-activating enzyme 1 (UBA1); FUNCTIONS IN: ubiquitin-protein ligase activity, ubiquitin activating enzyme activity; INVOLVED IN: response to cadmium ion, response to other organism, protein ubiquitination, ubiquitin-dependent protein catabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme, E1, active site (InterPro:IPR018074), Ubiquitin-activating enzyme, E1 (InterPro:IPR018075), Ubiquitin-activating enzyme e1, C-terminal (InterPro:IPR018965), Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme (InterPro:IPR019572), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040), Ubiquitin-activating enzyme, E1-like (InterPro:IPR000011); BEST Arabidopsis thaliana protein match is: ubiquitin activating enzyme 2 (TAIR:AT5G06460.1); Has 19490 Blast hits to 12603 proteins in 2346 species: Archae - 393; Bacteria - 11015; Metazoa - 2131; Fungi - 1366; Plants - 791; Viruses - 0; Other Eukaryotes - 3794 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12852329..12857727 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128566.4 → NP_565693.1 ubiquitin-activating enzyme 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565693.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P93028, Q8RX82

UniProtKB/TrEMBL

A0A178VN59, A0A654EYY3

Conserved Domains (1) summary

TIGR01408
Location:72 → 1078

Ube1; ubiquitin-activating enzyme E1