U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UGT74F2 UDP-glucosyltransferase 74F2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818986, updated on 7-Sep-2023

Summary

Go to the top of the page Help
Gene symbol
UGT74F2
Gene description
UDP-glucosyltransferase 74F2
Primary source
Araport:AT2G43820
Locus tag
AT2G43820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana salicylic acid glucosyltransferase 1; ATSAGT1; F18O19.7; GT; SAGT1; salicylic acid glucosyltransferase 1; SGT1; UDP-glucose:salicylic acid glucosyltransferase 1; UDP-glucosyltransferase 74F2
Summary
Induced by Salicylic acid, virus, fungus and bacteria.Involved in the tryptophan synthesis pathway. Independent of NPR1 for their induction by salicylic acid. UGT74F1 transfers UDP:glucose to salicylic acid (forming a glucoside (SAG) and a glucose ester (SGE)), benzoic acid, and athranilate in vitro. UGT74F2 shows a weak ability to catalyze the formation of the p-aminobenzoate-glucose ester in vitro. But, UGT75B1 appears to be the dominant pABA acylglucosyltransferase in vivo based on assays in leaves, flowers, and siliques. The true biological substrate(s) of UGT74F2 are not known, but mutant plants lacking UGT74F2 have a decreased level of SAG and SGE.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 2
Exon count:
2
Sequence:
Chromosome: 2; NC_003071.7 (18152078..18153908)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Actin-binding FH2 (formin homology 2) family protein Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene miscRNA Neighboring gene UDP-glycosyltransferase 74 F1 Neighboring gene ncRNA Neighboring gene Integrin-linked protein kinase family

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Overexpression of AtSGT1, an Arabidopsis salicylic acid glucosyltransferase, leads to increased susceptibility to Pseudomonas syringae. Song JT, et al. Phytochemistry, 2008 Mar. PMID 18226820
  2. Induction of a salicylic acid glucosyltransferase, AtSGT1, is an early disease response in Arabidopsis thaliana. Song JT. Mol Cells, 2006 Oct 31. PMID 17085977
  3. Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana. George Thompson AM, et al. Sci Rep, 2017 Apr 20. PMID 28425481, Free PMC Article
  4. The expression patterns of AtBSMT1 and AtSAGT1 encoding a salicylic acid (SA) methyltransferase and a SA glucosyltransferase, respectively, in Arabidopsis plants with altered defense responses. Song JT, et al. Mol Cells, 2009 Aug 31. PMID 19669626
  5. Metabolism of salicylic acid in wild-type, ugt74f1 and ugt74f2 glucosyltransferase mutants of Arabidopsis thaliana. Dean JV, et al. Physiol Plant, 2008 Apr. PMID 18248508

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Salicylic acid (SA) glucose conjugates are formed by two homologous UDP-glucosyltransferases (UGT74F1 and UGT74F2) that transfer glucose from UDP-glucose to SA.
    Title: Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana.
  2. Data show that the AtSAGT1-RNAi line exhibited no altered phenotypes upon pathogen infection, suggesting that (an)other SA glucosyltransferase(s) in Arabidopsis plants may be important for the pathogenesis of P. syringae. [AtSAGT1]
    Title: The expression patterns of AtBSMT1 and AtSAGT1 encoding a salicylic acid (SA) methyltransferase and a SA glucosyltransferase, respectively, in Arabidopsis plants with altered defense responses.
  3. The reduced resistance by AtSGT1 overexpression results from a reduction in salicylic acid content, which is at least in part caused by increases in methyl salicylate 2-O-beta-D-glucoside and methyl salicylate levels at the expense of salicylic acid.
    Title: Overexpression of AtSGT1, an Arabidopsis salicylic acid glucosyltransferase, leads to increased susceptibility to Pseudomonas syringae.
  4. isolation & characterization of UDP-glucose:salicylic acid glucosyltransferase1 (AtSGT1) gene; AtSGT1 was rapidly induced by exogenous SA & infection with Pseudomonas syringae, indicating pathogen-inducible AtSGT1 expression is an early disease response
    Title: Induction of a salicylic acid glucosyltransferase, AtSGT1, is an early disease response in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

NM_129944.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables UDP-glucose:4-aminobenzoate acylglucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables benzoic acid glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nicotinate-O-glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables salicylic acid glucosyltransferase (ester-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables salicylic acid glucosyltransferase (glucoside-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within benzoate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within para-aminobenzoic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of seed germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within salicylic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
UDP-glucosyltransferase 74F2
NP_181910.1
  • UDP-glucosyltransferase 74F2 (UGT74F2); CONTAINS InterPro DOMAIN/s: UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-glycosyltransferase 74 F1 (TAIR:AT2G43840.1); Has 8409 Blast hits to 8329 proteins in 546 species: Archae - 0; Bacteria - 818; Metazoa - 2323; Fungi - 31; Plants - 5038; Viruses - 125; Other Eukaryotes - 74 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    18152078..18153908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129944.3 → NP_181910.1  UDP-glucosyltransferase 74F2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181910.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22822
    UniProtKB/TrEMBL
    A0A178VQS4, A0A384KK07, A0A5S9X6R2, W8Q3A1
    Conserved Domains (1) summary
    PLN02173
    Location:1 → 449
    PLN02173; UDP-glucosyl transferase family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5U6M_A.1
5U6M_B.1
5U6S_A.1
5U6S_B.1
O22822.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools