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S6K2 serine/threonine protein kinase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820019, updated on 7-Sep-2023

Summary

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Gene symbol
S6K2
Gene description
serine/threonine protein kinase 2
Primary source
Araport:AT3G08720
Locus tag
AT3G08720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana protein kinase 19; ARABIDOPSIS THALIANA PROTEIN KINASE 2; ARABIDOPSIS THALIANA SERINE/THREONINE PROTEIN KINASE 2; ATPK19; ATPK2; ATS6K2; serine/threonine protein kinase 2
Summary
Encodes a ribosomal-protein S6 kinase. Gene expression is induced by cold and salt (NaCl). Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Phosphorylates specifically mammalian and plant S6 at 25 degrees C but not at 37 degrees C. Involved in translational up-regulation of ribosomal proteins.
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Genomic context

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Location:
chromosome: 3
Exon count:
7
Sequence:
Chromosome: 3; NC_003074.8 (2648372..2651231, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme 12 Neighboring gene thioredoxin H-type 9 Neighboring gene protein-serine kinase 1 Neighboring gene elongation factor P (EF-P) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001337766.1
NM_001337767.1
NM_111706.4
NM_180212.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
acts_upstream_of_or_within positive regulation of translation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine protein kinase 2
NP_187484.1
  • serine/threonine protein kinase 2 (S6K2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), AGC-kinase, C-terminal (InterPro:IPR000961), Protein kinase, C-terminal (InterPro:IPR017892), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: protein-serine kinase 1 (TAIR:AT3G08730.1); Has 133901 Blast hits to 131707 proteins in 4554 species: Archae - 204; Bacteria - 15943; Metazoa - 48718; Fungi - 13429; Plants - 32816; Viruses - 561; Other Eukaryotes - 22230 (source: NCBI BLink).
NP_850543.1
  • Arabidopsis thaliana protein kinase 19 (ATPK19); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), AGC-kinase, C-terminal (InterPro:IPR000961), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, C-terminal (InterPro:IPR017892), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: protein-serine kinase 1 (TAIR:AT3G08730.1); Has 133901 Blast hits to 131707 proteins in 4554 species: Archae - 204; Bacteria - 15943; Metazoa - 48718; Fungi - 13429; Plants - 32816; Viruses - 561; Other Eukaryotes - 22230 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    2648372..2651231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111706.4 → NP_187484.1  serine/threonine protein kinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187484.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0V851, Q39030, Q949X5, Q9C5R1
    UniProtKB/TrEMBL
    A0A178VG08, A0A5S9XAI2
    Conserved Domains (3) summary
    smart00133
    Location:398 → 458
    S_TK_X; Extension to Ser/Thr-type protein kinases
    smart00220
    Location:140 → 395
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05123
    Location:146 → 395
    STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases

  2. NM_180212.2 → NP_850543.1  serine/threonine protein kinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850543.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0V851, Q39030, Q949X5, Q9C5R1
    UniProtKB/TrEMBL
    A0A178VG08, A0A5S9XAI2
    Conserved Domains (3) summary
    smart00133
    Location:398 → 458
    S_TK_X; Extension to Ser/Thr-type protein kinases
    smart00220
    Location:140 → 395
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05123
    Location:146 → 395
    STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases

  3. NM_001337766.1 → NP_001327295.1  serine/threonine protein kinase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0V851, Q39030, Q949X5, Q9C5R1
    UniProtKB/TrEMBL
    A0A178VG08, A0A5S9XAI2

  4. NM_001337767.1 → NP_001327294.1  serine/threonine protein kinase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0V851, Q39030, Q949X5, Q9C5R1
    UniProtKB/TrEMBL
    A0A178VG08, A0A5S9XAI2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39030.2

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