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PK1 protein-serine kinase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820020, updated on 7-Sep-2023

Summary

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Gene symbol
PK1
Gene description
protein-serine kinase 1
Primary source
Araport:AT3G08730
Locus tag
AT3G08730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 1; ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 6; ATPK1; ATPK6; ATS6K1; P70 RIBOSOMAL S6 KINASE; PK6; PROTEIN-SERINE KINASE; protein-serine kinase 1; ROTEIN-SERINE KINASE 6; S6K1
Summary
Encodes a protein-serine kinase that phosphorylates ribosomal protein in vitro. Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Involved in translational up-regulation of ribosomal proteins. Phosphorylated by PDK1. Interacts with RAPTOR1, which in turn interacts with TOR. SPK6 activity is affected by osmotic stress, and plants overexpressing S6k1 are hypersensitive to osmotic stress. The gene is expressed in all tissues examined, with highest expression level detected in metabolically active tissues.
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Genomic context

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See PK1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Sequence:
Chromosome: 3; NC_003074.8 (2651321..2654212, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene thioredoxin H-type 9 Neighboring gene serine/threonine protein kinase 2 Neighboring gene elongation factor P (EF-P) family protein Neighboring gene F-box and associated interaction domains-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. II. Functional and biochemical analysis of the encoded protein. Zhang SH, et al. J Biol Chem, 1994 Jul 1. PMID 8021267
  2. Molecular details of the Raptor-binding motif on Arabidopsis S6 kinase. Son O, et al. Biochem Biophys Res Commun, 2017 Apr 22. PMID 28285138
  3. A heat-sensitive Arabidopsis thaliana kinase substitutes for human p70s6k function in vivo. Turck F, et al. Mol Cell Biol, 1998 Apr. PMID 9528776, Free PMC Article
  4. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. I. Isolation, characterization, and expression. Zhang SH, et al. J Biol Chem, 1994 Jul 1. PMID 7912697
  5. Two genes that encode ribosomal-protein S6 kinase homologs are induced by cold or salinity stress in Arabidopsis thaliana. Mizoguchi T, et al. FEBS Lett, 1995 Jan 23. PMID 7828736

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A 12-amino acid core element in S6 kinase 1 (AtS6K1) was identified as an essential interacting region with Raptor1 protein.
    Title: Molecular details of the Raptor-binding motif on Arabidopsis S6 kinase.
  2. identified a 44-amino acid region at the N-terminal end of ribosomal S6 kinase 1 (S6K1) specifically interacted with Raptor1, indicating that this region may contain a functional equivalent of TOS (TOR-Signaling) motif present in mammalian TOR substrates
    Title: Identification of the Raptor-binding motif on Arabidopsis S6 kinase and its use as a TOR signaling suppressor.
  3. S6K1 interacts with retinoblastoma related protein (RBR)1 via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.
    Title: S6K1 and E2FB are in mutually antagonistic regulatory links controlling cell growth and proliferation in Arabidopsis.
  4. Authors propose that TOR functions in polysomes to maintain the active S6K1 (and thus eIF3h) phosphorylation status that is critical for translation reinitiation.
    Title: TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h.
  5. The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.
    Title: Arabidopsis S6 kinase mutants display chromosome instability and altered RBR1-E2F pathway activity.
  6. Arabidopsis RAPTOR1 (a TOR regulatory protein) interacts with the HEAT repeats of TOR and that RAPTOR1 regulates the activity of S6 kinase (S6K) in response to osmotic stress [S6K1]
    Title: Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001337768.1
NM_111707.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of translation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein-serine kinase 1
NP_187485.1
  • protein-serine kinase 1 (PK1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase, C-terminal (InterPro:IPR017892), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), AGC-kinase, C-terminal (InterPro:IPR000961), Protein kinase, catalytic domain (InterPro:IPR000719); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 2 (TAIR:AT3G08720.2); Has 134224 Blast hits to 132007 proteins in 4588 species: Archae - 200; Bacteria - 15979; Metazoa - 48799; Fungi - 13454; Plants - 32927; Viruses - 586; Other Eukaryotes - 22279 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    2651321..2654212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111707.4 → NP_187485.1  protein-serine kinase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187485.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42818, Q8LFC1
    UniProtKB/TrEMBL
    A0A178VLF0, A0A5S9XA91
    Conserved Domains (2) summary
    smart00133
    Location:390 → 452
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd05123
    Location:140 → 389
    STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases

  2. NM_001337768.1 → NP_001326081.1  protein-serine kinase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42818, Q8LFC1
    UniProtKB/TrEMBL
    A0A178VLF0, A0A5S9XA91
    Conserved Domains (2) summary
    smart00133
    Location:390 → 452
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd05123
    Location:140 → 389
    STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAB33197.1
P42818.1

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