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ABCC6 multidrug resistance-associated protein 8 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820497, updated on 15-Oct-2023

Summary

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Gene symbol
ABCC6
Gene description
multidrug resistance-associated protein 8
Primary source
Araport:AT3G13090
Locus tag
AT3G13090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATABCC6; ATMRP8; ATP-binding cassette C6; MRP8; multidrug resistance-associated protein 8
Summary
member of MRP subfamily
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Genomic context

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See ABCC6 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Sequence:
Chromosome: 3; NC_003074.8 (4202811..4208261, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene CBS domain-containing protein / transporter associated domain-containing protein Neighboring gene uncharacterized protein Neighboring gene multidrug resistance-associated protein 3 Neighboring gene miscRNA Neighboring gene multidrug resistance-associated protein 7 Neighboring gene serine acetyltransferase 2;2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis thaliana ABC protein superfamily, a complete inventory. Sánchez-Fernández R, et al. J Biol Chem, 2001 Aug 10. PMID 11346655
  2. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
  3. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
  4. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
  5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_112148.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ABC-type xenobiotic transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
multidrug resistance-associated protein 8
NP_187916.3
  • multidrug resistance-associated protein 8 (MRP8); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 7 (TAIR:AT3G13100.1); Has 618731 Blast hits to 341231 proteins in 4024 species: Archae - 11229; Bacteria - 503340; Metazoa - 11410; Fungi - 6818; Plants - 5765; Viruses - 13; Other Eukaryotes - 80156 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    4202811..4208261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112148.4 → NP_187916.3  multidrug resistance-associated protein 8 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187916.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8VZZ4, Q9LK63
    UniProtKB/TrEMBL
    A0A5S9XBV2, A0A654F6L0
    Conserved Domains (4) summary
    cd03244
    Location:1217 → 1437
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:601 → 801
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    PLN03232
    Location:67 → 1452
    PLN03232; ABC transporter C family member; Provisional
    cl00549
    Location:902 → 1173
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VZZ4.3

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