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TOP6B topoisomerase 6 subunit B [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821626, updated on 7-Sep-2023

Summary

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Gene symbol
TOP6B
Gene description
topoisomerase 6 subunit B
Primary source
Araport:AT3G20780
Locus tag
AT3G20780
See related
TAIR:AT3G20780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATTOP6B; BIN3; BRASSINOSTEROID INSENSITIVE 3; ELONGATED HYPOCOTYL 6; HARLEQUIN; HLQ; HYP6; RHL3; ROOT HAIRLESS 3; topoisomerase 6 subunit B; topoisomerase 6 subunit B
Summary
Encodes putative eukaryotic homolog of archaebacterial topoisomerase VI subunit B, TOP6B. Is essential for endoreduplication and is involved in cell expansion and cell proliferation. The hlq (harlequin) dwarf mutant has fewer root hair and leaf trichome. It has abnormal epidermal cell and accumulates callose.
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Genomic context

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See TOP6B in Genome Data Viewer
Location:
chromosome: 3
Exon count:
19
Sequence:
Chromosome: 3; NC_003074.8 (7263900..7268750, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Nse4, component of Smc5/6 DNA repair complex Neighboring gene Ethylene insensitive 3 family protein Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene ncRNA Neighboring gene Cell differentiation, Rcd1-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TOPOISOMERASE 6B is involved in chromatin remodelling associated with control of carbon partitioning into secondary metabolites and cell walls, and epidermal morphogenesis in Arabidopsis. Mittal A, et al. J Exp Bot, 2014 Aug. PMID 24821950, Free PMC Article
  2. An archaebacterial topoisomerase homolog not present in other eukaryotes is indispensable for cell proliferation of plants. Hartung F, et al. Curr Biol, 2002 Oct 15. PMID 12401176
  3. A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development. Yin Y, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12119417, Free PMC Article
  4. Harlequin (hlq) and short blue root (sbr), two Arabidopsis mutants that ectopically express an abscisic acid- and auxin-inducible transgenic carrot promoter and have pleiotropic effects on morphogenesis. Subramanian S, et al. Plant Mol Biol, 2002 May. PMID 12008902
  5. A genetic screen for mutants defective in IAA1-LUC degradation in Arabidopsis thaliana reveals an important requirement for TOPOISOMERASE6B in auxin physiology. Gilkerson J, et al. Plant Signal Behav, 2014. PMID 25482814, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicated that AtPRD1 may act as a bridge protein to interact with AtPRD3 and AtDFO, and interact directly with the Topo VI-like proteins MTOPVIB, AtSPO11-1 and AtSPO11-2 to take part in DNA double-strand break formation in Arabidopsis.
    Title: MTOPVIB interacts with AtPRD1 and plays important roles in formation of meiotic DNA double-strand breaks in Arabidopsis.
  2. These data suggest that increased IAA1-luciferase fusion protein half-life in top6b-7 probably results from a combination of both lower endogenous IAA levels and reduced sensitivity to auxin.
    Title: A genetic screen for mutants defective in IAA1-LUC degradation in Arabidopsis thaliana reveals an important requirement for TOPOISOMERASE6B in auxin physiology.
  3. role in the regulation of chromatin remodelling to mediate development in response to environmental and hormonal signals
    Title: TOPOISOMERASE 6B is involved in chromatin remodelling associated with control of carbon partitioning into secondary metabolites and cell walls, and epidermal morphogenesis in Arabidopsis.
  4. A functional connection between COP1 and the TOPOVI in plants links COP1-dependent development with the regulation of endoreduplication.
    Title: MIDGET connects COP1-dependent development with endoreduplication in Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_112969.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to brassinosteroid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within trichome differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
topoisomerase 6 subunit B
NP_188714.2
  • topoisomerase 6 subunit B (TOP6B); CONTAINS InterPro DOMAIN/s: DNA topoisomerase VI, subunit B, transducer (InterPro:IPR015320), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), ATPase-like, ATP-binding domain (InterPro:IPR003594); Has 873 Blast hits to 542 proteins in 165 species: Archae - 495; Bacteria - 44; Metazoa - 2; Fungi - 2; Plants - 34; Viruses - 0; Other Eukaryotes - 296 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7263900..7268750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112969.3 → NP_188714.2  topoisomerase 6 subunit B [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188714.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9C5V6, Q9LT43
    UniProtKB/TrEMBL
    A0A5S9XE17, A0A654FA26
    Conserved Domains (1) summary
    PRK04184
    Location:22 → 595
    PRK04184; DNA topoisomerase VI subunit B; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C5V6.1

Gene LinkOut

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