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CAM7 calmodulin 7 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 823492, updated on 7-Sep-2023

Summary

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Gene symbol
CAM7
Gene description
calmodulin 7
Primary source
Araport:AT3G43810
Locus tag
AT3G43810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtCAM7; calmodulin 7; CALMODULIN 7; Z-box Binding Factor 3; ZBF3
Summary
EF hand domain protein encodes a calmodulin. Can functionally complement a yeast CaM mutant.
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Genomic context

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Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (15663000..15666469, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene zinc induced facilitator-like 2 Neighboring gene glutathione S-transferase tau 27 Neighboring gene miscRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of Arabidopsis thaliana calmodulin7 and insight into its mode of DNA binding. Kumar S, et al. FEBS Lett, 2016 Sep. PMID 27500568
  2. The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis. Zeb Q, et al. J Integr Plant Biol, 2020 Jul. PMID 31755194
  3. CAM7 and HY5 genetically interact to regulate root growth and abscisic acid responses. Abbas N, et al. Plant Signal Behav, 2014. PMID 25763709, Free PMC Article
  4. A bimodular mechanism of calcium control in eukaryotes. Tidow H, et al. Nature, 2012 Nov 15. PMID 23086147
  5. Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8. Tidow H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Mar 1. PMID 20208181, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis.
    Title: The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis.
  2. We validated the model using biolayer interferometry, which confirmed that AtCaM7 interacts with Z-box DNA with high affinity
    Title: Crystal structure of Arabidopsis thaliana calmodulin7 and insight into its mode of DNA binding.
  3. CaM7 as a PEN3-interacting protein crucial to Arabidopsis Nonhost resistance (NHR) and emphasizes the importance of Ca(2+) sensing to plant immunity.
    Title: ABC transporter PEN3/PDR8/ABCG36 interacts with calmodulin that, like PEN3, is required for Arabidopsis nonhost resistance.
  4. Investigated the root phenotype of cam7 hy5 double mutants and showed that CAM7 and HY5 genetically interact to control the root growth. We have further shown an interdependent function of HY5 and CAM7 in abscisic acid responsiveness.
    Title: CAM7 and HY5 genetically interact to regulate root growth and abscisic acid responses.
  5. results demonstrate that CAM7 and HY5 directly interact with the HY5 promoter to mediate the transcriptional activity of HY5 during Arabidopsis seedling development
    Title: Arabidopsis CAM7 and HY5 physically interact and directly bind to the HY5 promoter to regulate its expression and thereby promote photomorphogenesis.
  6. complex between calmodulin and the regulatory domain of the plasma-membrane Ca(2+)-ATPase ACA8 from Arabidopsis has been crystallized. Crystals belonged to space group C2, with unit-cell parameters a = 176.8, b = 70.0, c = 69.8 A, beta = 113.2 degrees.
    Title: Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8.
  7. Data show that there is a concerted function of CAM7 and HY5 basic leucine zipper transcription factor in Arabidopsis seedling development.
    Title: Calmodulin7 plays an important role as transcriptional regulator in Arabidopsis seedling development.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001339108.1
NM_001339109.1
NM_114249.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium-mediated signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within detection of calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within regulation of photomorphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calmodulin 7
NP_189967.1
  • calmodulin 7 (CAM7); FUNCTIONS IN: calcium ion binding; INVOLVED IN: detection of calcium ion, calcium-mediated signaling, regulation of photomorphogenesis; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 5 (TAIR:AT2G27030.3); Has 33955 Blast hits to 23167 proteins in 1763 species: Archae - 4; Bacteria - 223; Metazoa - 14467; Fungi - 7347; Plants - 6966; Viruses - 0; Other Eukaryotes - 4948 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    15663000..15666469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001339107.1 → NP_001326523.1  calmodulin 7 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LPJ2, A0A7G2EN73

  2. NM_114249.4 → NP_189967.1  calmodulin 7 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_189967.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P59220
    UniProtKB/TrEMBL
    A0A178VGB3, A0A384LJK0, A8Y7S8, Q1H5F3
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 149
    PTZ00184; calmodulin; Provisional

  3. NM_001339108.1 → NP_001326524.1  calmodulin 7 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LPJ1
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 113
    PTZ00184; calmodulin; Provisional

  4. NM_001339109.1 → NP_001326522.1  calmodulin 7 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LPJ1
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 113
    PTZ00184; calmodulin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
4AQR_A.1
4AQR_B.1
5A2H_A.1
P59220.2

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