U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AAE3 AMP-dependent synthetase and ligase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824060, updated on 28-Feb-2024

Summary

Go to the top of the page Help
Gene symbol
AAE3
Gene description
AMP-dependent synthetase and ligase family protein
Primary source
Araport:AT3G48990
Locus tag
AT3G48990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ACYL-ACTIVATING ENZYME 3
Summary
Encodes an oxalyl-CoA synthetase and is required for oxalate degradation, for normal seed development, and for defense against an oxalate-producing fungal pathogen.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_003074.8 (18158565..18161486, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene O-glucosyltransferase rumi-like protein (DUF821) Neighboring gene RNA polymerase III subunit RPC82 family protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A previously unknown oxalyl-CoA synthetase is important for oxalate catabolism in Arabidopsis. Foster J, et al. Plant Cell, 2012 Mar. PMID 22447686, Free PMC Article
  2. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
  3. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
  4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
  5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of the Arabidopsis Acyl-Activating Enzyme 3 Impairs Seed Coat Mucilage Accumulation and Seed Germination.
    Title: Disruption of the Arabidopsis Acyl-Activating Enzyme 3 Impairs Seed Coat Mucilage Accumulation and Seed Germination.
  2. Oxalyl-CoA synthetase is required for oxalate degradation, for normal seed development, and for defense against an oxalate-producing fungal pathogen.
    Title: A previously unknown oxalyl-CoA synthetase is important for oxalate catabolism in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_114758.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables oxalate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oxalate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of seed germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within seed coat development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plasmodesma HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
AMP-dependent synthetase and ligase family protein
NP_190468.1
  • AMP-dependent synthetase and ligase family protein; FUNCTIONS IN: catalytic activity, AMP binding; INVOLVED IN: response to cadmium ion; LOCATED IN: apoplast, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT4G05160.1); Has 84840 Blast hits to 77127 proteins in 3761 species: Archae - 1146; Bacteria - 54375; Metazoa - 3415; Fungi - 4706; Plants - 2571; Viruses - 1; Other Eukaryotes - 18626 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    18158565..18161486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114758.5 → NP_190468.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190468.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8L9Z5, Q9SMT7
    UniProtKB/TrEMBL
    A0A178V7A3, A0A5S9XJ86, A0A654FE46
    Conserved Domains (1) summary
    cd05926
    Location:18 → 508
    FACL_fum10p_like; Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5IE0_A.1
5IE0_B.1
5IE2_A.1
5IE2_B.1
5IE3_A.1
5IE3_B.1
Q9SMT7.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Tools