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ADSS adenylosuccinate synthase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824930, updated on 15-Oct-2023

Summary

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Gene symbol
ADSS
Gene description
adenylosuccinate synthase
Primary source
Araport:AT3G57610
Locus tag
AT3G57610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
adenylosuccinate synthase; ATPURA
Summary
encoding adenylosuccinate synthetase (AdSS), the enzyme involved in the first step of the formation of the purine nucleotide AMP (conversion of IMP to adenylo-succinate)
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Genomic context

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Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (21334191..21336720, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene glyoxal oxidase-related protein Neighboring gene exostosin family protein Neighboring gene Protein kinase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase. Fonné-Pfister R, et al. Proc Natl Acad Sci U S A, 1996 Sep 3. PMID 8790347, Free PMC Article
  2. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
  3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
  4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
  5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_115621.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables adenylosuccinate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylosuccinate synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within AMP biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
adenylosuccinate synthase
NP_191320.1
  • adenylosuccinate synthase (ADSS); FUNCTIONS IN: adenylosuccinate synthase activity; INVOLVED IN: response to cadmium ion, purine ribonucleotide biosynthetic process, AMP biosynthetic process; LOCATED IN: apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Adenylosuccinate synthase, active site (InterPro:IPR018220), Adenylosuccinate synthetase (InterPro:IPR001114); Has 10496 Blast hits to 10490 proteins in 2781 species: Archae - 222; Bacteria - 5613; Metazoa - 213; Fungi - 143; Plants - 71; Viruses - 18; Other Eukaryotes - 4216 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    21334191..21336720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115621.5 → NP_191320.1  adenylosuccinate synthase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191320.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q96529
    UniProtKB/TrEMBL
    A0A5S9XNF3, A0A654FIP2, Q8LEZ6
    Conserved Domains (1) summary
    PLN02513
    Location:65 → 490
    PLN02513; adenylosuccinate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96529.1

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