CCD1 carotenoid cleavage dioxygenase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Gene symbol: CCD1
Gene description: carotenoid cleavage dioxygenase 1
Primary source: Araport:AT3G63520
Locus tag: AT3G63520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCCD1; ATNCED1; carotenoid cleavage dioxygenase 1; CAROTENOID CLEAVAGE DIOXYGENASE 1; NCED1
Summary: Encodes a protein with 9-cis-epoxycarotenoid dioxygenase activity. The enzyme was shown to act on a variety of carotenoid including beta-carotene, lutein, zeaxanthin, and all-trans-violaxanthin. When those compounds are used as substrates, the major reaction product detected is a C14 dialdehyde: 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial. The enzyme did not cleave as efficiently carotenoids containing 9-cis-double or allenic bonds.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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A cysteine residue may modulate substrate affinity and (or) the reaction rate of AtCCD1.
Title: Identification and characterization of a unique cysteine residue proximal to the catalytic site of Arabidopsis thaliana carotenoid cleavage enzyme 1.
AtCCD1 from Arabidopsis thaliana is a dioxygenase
Title: The carotenase AtCCD1 from Arabidopsis thaliana is a dioxygenase.
Ectopic expression of AhNCED1 gene in 129B08/nced3 mutant Arabidopsis driven by the AtNCED3 promoter restores its ability to accumulate ABA during drought stress, and reverts its hypersensitivity to nonionic osmotic stress and soil drought.
Title: Regulation of ABA level and water-stress tolerance of Arabidopsis by ectopic expression of a peanut 9-cis-epoxycarotenoid dioxygenase gene.

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NM_116217.3

Function	Evidence Code	Pubs
enables 9-cis-epoxycarotenoid dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carotene catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within carotenoid catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info
acts_upstream_of_or_within xanthophyll catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

NP_191911.1

carotenoid cleavage dioxygenase 1 (CCD1); FUNCTIONS IN: 9-cis-epoxycarotenoid dioxygenase activity; INVOLVED IN: response to water deprivation, carotene catabolic process, xanthophyll catabolic process, carotenoid catabolic process; LOCATED IN: plasma membrane, vacuole, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carotenoid oxygenase (InterPro:IPR004294); BEST Arabidopsis thaliana protein match is: nine-cis-epoxycarotenoid dioxygenase 4 (TAIR:AT4G19170.1); Has 2926 Blast hits to 2896 proteins in 500 species: Archae - 16; Bacteria - 808; Metazoa - 317; Fungi - 194; Plants - 866; Viruses - 0; Other Eukaryotes - 725 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain