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ARGAH1 arginase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 826468, updated on 7-Sep-2023

Summary

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Gene symbol
ARGAH1
Gene description
arginase
Primary source
Araport:AT4G08900
Locus tag
AT4G08900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
arginine amidohydrolase 1
Summary
Encodes an arginase, likely to be involved in polyamine biosynthesis in pollen.
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Genomic context

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See ARGAH1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
6
Sequence:
Chromosome: 4; NC_003075.7 (5703311..5705439)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene homeobox protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Neighboring Subunit Is Engaged to Stabilize the Substrate in the Active Site of Plant Arginases. Sekula B. Front Plant Sci, 2020. PMID 32754173, Free PMC Article
  2. Arginase induction represses gall development during clubroot infection in Arabidopsis. Gravot A, et al. Plant Cell Physiol, 2012 May. PMID 22433460
  3. Dual functioning of plant arginases provides a third route for putrescine synthesis. Patel J, et al. Plant Sci, 2017 Sep. PMID 28716421
  4. Manipulation of arginase expression modulates abiotic stress tolerance in Arabidopsis: effect on arginine metabolism and ROS accumulation. Shi H, et al. J Exp Bot, 2013 Mar. PMID 23378380, Free PMC Article
  5. Analysis of Arabidopsis arginase gene transcription patterns indicates specific biological functions for recently diverged paralogs. Brownfield DL, et al. Plant Mol Biol, 2008 Jul. PMID 18425591

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtARGAHs negatively regulate many abiotic stress tolerances, at least partially, attribute to their roles in modulating arginine metabolism and reactive oxygen species accumulation. [AtARGAH1]
    Title: Manipulation of arginase expression modulates abiotic stress tolerance in Arabidopsis: effect on arginine metabolism and ROS accumulation.
  2. The mutation of the arginase-encoding gene ARGAH2 abrogates clubroot-induced arginase activity and results in enhanced gall size in infected roots.
    Title: Arginase induction represses gall development during clubroot infection in Arabidopsis.
  3. Gene mutations within ARGAH1 or ARGAH2 are associated with increased nitric oxide signaling in root development. [ARGAH1]
    Title: Arginase-negative mutants of Arabidopsis exhibit increased nitric oxide signaling in root development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_116959.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables agmatinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arginase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables arginase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cobalt ion binding HDA PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within arginine catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein hexamerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in putrescine biosynthetic process from arginine, using agmatinase IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in urea cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
arginase
NP_192629.1
  • arginase; FUNCTIONS IN: arginase activity, cobalt ion binding, agmatinase activity; INVOLVED IN: defense response to bacterium, arginine catabolic process, polyamine metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 8 plant structures; CONTAINS InterPro DOMAIN/s: Ureohydrolase (InterPro:IPR006035), Ureohydrolase, manganese-binding site (InterPro:IPR020855); BEST Arabidopsis thaliana protein match is: Arginase/deacetylase superfamily protein (TAIR:AT4G08870.1); Has 9226 Blast hits to 9224 proteins in 1712 species: Archae - 292; Bacteria - 4928; Metazoa - 419; Fungi - 376; Plants - 74; Viruses - 0; Other Eukaryotes - 3137 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    5703311..5705439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116959.4 → NP_192629.1  arginase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192629.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46637
    UniProtKB/TrEMBL
    A0A178UW48, A0A5S9XQL9
    Conserved Domains (1) summary
    PLN02615
    Location:2 → 342
    PLN02615; arginase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46637.1

Gene LinkOut

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