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GOX3 Aldolase-type TIM barrel family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827563, updated on 6-Oct-2023

Summary

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Gene symbol
GOX3
Gene description
Aldolase-type TIM barrel family protein
Primary source
Araport:AT4G18360
Locus tag
AT4G18360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F28J12.20; F28J12_20; glycolate oxidase 3
Summary
Encodes a glycolate oxidase that modulates reactive oxygen species-mediated signal transduction during nonhost resistance.
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Genomic context

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Location:
chromosome: 4
Exon count:
13
Sequence:
Chromosome: 4; NC_003075.7 (10145895..10148764, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Glycosyl hydrolase superfamily protein Neighboring gene nine-cis-epoxycarotenoid dioxygenase 2 Neighboring gene ncRNA Neighboring gene DEGP protease 5 Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GLYCOLATE OXIDASE3, a Glycolate Oxidase Homolog of Yeast l-Lactate Cytochrome c Oxidoreductase, Supports l-Lactate Oxidation in Roots of Arabidopsis. Engqvist MK, et al. Plant Physiol, 2015 Oct. PMID 26246447, Free PMC Article
  2. Glycolate oxidase modulates reactive oxygen species-mediated signal transduction during nonhost resistance in Nicotiana benthamiana and Arabidopsis. Rojas CM, et al. Plant Cell, 2012 Jan. PMID 22286136, Free PMC Article
  3. Proteome analysis of peroxisomes from etiolated Arabidopsis seedlings identifies a peroxisomal protease involved in β-oxidation and development. Quan S, et al. Plant Physiol, 2013 Dec. PMID 24130194, Free PMC Article
  4. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
  5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GOX3(At4g18360) is the enzyme that metabolizes l-lactate to pyruvate.GOX3 is predominantly present in roots and mature to aging leaves but is largely absent from young photosynthetic leaves.[
    Title: GLYCOLATE OXIDASE3, a Glycolate Oxidase Homolog of Yeast l-Lactate Cytochrome c Oxidoreductase, Supports l-Lactate Oxidation in Roots of Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001084937.1
NM_001341276.1
NM_001341277.1
NM_117946.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables (S)-2-hydroxy-acid oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxidative photosynthetic carbon pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in peroxisome HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Aldolase-type TIM barrel family protein
NP_001078406.1
  • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity, oxidoreductase activity, FMN binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14420.2); Has 9948 Blast hits to 9918 proteins in 1541 species: Archae - 28; Bacteria - 4496; Metazoa - 367; Fungi - 686; Plants - 255; Viruses - 0; Other Eukaryotes - 4116 (source: NCBI BLink).
NP_193570.1
  • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity, oxidoreductase activity, FMN binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14420.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    10145895..10148764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_117946.3 → NP_193570.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_193570.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MRC3, O49506
    UniProtKB/TrEMBL
    A0A654FQJ9
    Conserved Domains (2) summary
    PLN02493
    Location:1 → 364
    PLN02493; probable peroxisomal (S)-2-hydroxy-acid oxidase
    cd02809
    Location:8 → 351
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...

  2. NM_001341276.1 → NP_001329915.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B993

  3. NM_001084937.1 → NP_001078406.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078406.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV33, A0A654FQJ9
    Conserved Domains (1) summary
    cd02809
    Location:8 → 307
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...

  4. NM_001341277.1 → NP_001329914.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MRC3, O49506
    UniProtKB/TrEMBL
    A0A654FQJ9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O49506.1

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