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BRCA1 breast cancer susceptibility1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827854, updated on 26-May-2022

Summary

Gene symbol
BRCA1
Gene description
breast cancer susceptibility1
Primary source
Araport:AT4G21070
Locus tag
AT4G21070
Gene type
protein coding
RNA name
breast cancer susceptibility1
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA BREAST CANCER SUSCEPTIBILITY1; ATBRCA1; breast cancer susceptibility1
Summary
Encodes AtBRCA1, an ortholog of the human breast cancer susceptibility gene 1. Contains one N-terminal RING finger, two C-terminal BRCT and the p300/CBP interacting domain. Strongly induced by gamma rays, consistent with a putative role in DNA repair and in cell cycle control.
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Genomic context

See BRCA1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
14
Sequence:
Chromosome: 4; NC_003075.7 (11247991..11252757)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Dof-type zinc finger domain-containing protein Neighboring gene MITOCHONDRIAL FERREDOXIN 2

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
breast cancer susceptibility1
NP_193839.4
  • breast cancer susceptibility1 (BRCA1); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: DNA repair, response to gamma radiation; LOCATED IN: intracellular, nucleus; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), BRCA1 (InterPro:IPR011364), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: breast cancer associated RING 1 (TAIR:AT1G04020.2); Has 8999 Blast hits to 8407 proteins in 1134 species: Archae - 0; Bacteria - 191; Metazoa - 6557; Fungi - 520; Plants - 721; Viruses - 32; Other Eukaryotes - 978 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    11247991..11252757
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118225.5NP_193839.4  breast cancer susceptibility1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_193839.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXD4
    Conserved Domains (6) summary
    pfam00985
    Location:339467
    MSA_2; Merozoite Surface Antigen 2 (MSA-2) family
    smart00292
    Location:842932
    BRCT; breast cancer carboxy-terminal domain
    cd00162
    Location:1556
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:14243
    rad18; DNA repair protein rad18
    cd15571
    Location:596678
    ePHD; Extended plant homeodomain (PHD) finger, characterized by Cys2HisCys5HisCys2His
    pfam00533
    Location:724806
    BRCT; BRCA1 C Terminus (BRCT) domain