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AT5G23250 Succinyl-CoA ligase, alpha subunit [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832389, updated on 3-Apr-2024

Summary

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Gene symbol
AT5G23250
Gene description
Succinyl-CoA ligase, alpha subunit
Primary source
Araport:AT5G23250
Locus tag
AT5G23250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MKD15.11; MKD15_11
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Genomic context

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Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (7830318..7832843)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNAJ heat shock N-terminal domain-containing protein Neighboring gene nicotinamidase 2 Neighboring gene miscRNA Neighboring gene K-box region and MADS-box transcription factor family protein Neighboring gene sugar transporter 11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
  2. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article
  3. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
  4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
  5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001125791.2
NM_001343795.1
NM_122231.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables copper ion binding HDA PubMed 
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Succinyl-CoA ligase, alpha subunit
NP_001119263.1
  • Succinyl-CoA ligase, alpha subunit; FUNCTIONS IN: succinate-CoA ligase (GDP-forming) activity, copper ion binding; INVOLVED IN: metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Succinyl-CoA ligase, alpha subunit (InterPro:IPR005810), ATP-citrate lyase/succinyl-CoA ligase (InterPro:IPR005811), NAD(P)-binding domain (InterPro:IPR016040), ATP-citrate lyase/succinyl-CoA ligase, active site (InterPro:IPR017440), CoA-binding (InterPro:IPR003781), Succinyl-CoA synthetase-like (InterPro:IPR016102); BEST Arabidopsis thaliana protein match is: Succinyl-CoA ligase, alpha subunit (TAIR:AT5G08300.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_197716.1
  • Succinyl-CoA ligase, alpha subunit; FUNCTIONS IN: succinate-CoA ligase (GDP-forming) activity, copper ion binding; INVOLVED IN: metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Succinyl-CoA ligase, alpha subunit (InterPro:IPR005810), ATP-citrate lyase/succinyl-CoA ligase (InterPro:IPR005811), NAD(P)-binding domain (InterPro:IPR016040), CoA-binding (InterPro:IPR003781), ATP-citrate lyase/succinyl-CoA ligase, active site (InterPro:IPR017440), Succinyl-CoA synthetase-like (InterPro:IPR016102); BEST Arabidopsis thaliana protein match is: Succinyl-CoA ligase, alpha subunit (TAIR:AT5G08300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7830318..7832843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001125791.2 → NP_001119263.1  Succinyl-CoA ligase, alpha subunit [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001119263.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UAS6, B3H632
    Conserved Domains (3) summary
    PTZ00187
    Location:30 → 295
    PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
    pfam02629
    Location:50 → 143
    CoA_binding; CoA binding domain
    cl22543
    Location:196 → 295
    Ligase_CoA; CoA-ligase

  2. NM_122231.4 → NP_197716.1  Succinyl-CoA ligase, alpha subunit [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197716.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LAD2, Q9FMX5
    UniProtKB/TrEMBL
    A0A178UAS6, A0A5S9Y6V8, A0A654G3K0
    Conserved Domains (1) summary
    PLN00125
    Location:41 → 340
    PLN00125; Succinyl-CoA ligase [GDP-forming] subunit alpha

  3. NM_001343795.1 → NP_001331781.1  Succinyl-CoA ligase, alpha subunit [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BEZ0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LAD2.2

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