ABCB27 transporter associated with antigen processing protein 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: ABCB27
Gene description: transporter associated with antigen processing protein 2
Primary source: Araport:AT5G39040
Locus tag: AT5G39040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ALS1; ALUMINUM SENSITIVE 1; ARABIDOPSIS THALIANA TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING PROTEIN 2; AtALS1; ATP-binding cassette B27; ATTAP2; MXF12.50; MXF12_50; TAP2; transporter associated with antigen processing protein 2
Summary: Encodes a member of TAP subfamily of ABC transporters that is located in the vacuole. Mutants are hypersensitive to aluminum and the gene product may be important for intracellular movement of some substrate, possibly chelated Al, as part of a mechanism of aluminum sequestration.
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Genomic context

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Location:: chromosome: 5

Exon count:: 17

Sequence:: Chromosome: 5; NC_003076.8 (15625460..15629835)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Auxin negatively regulates aluminum tolerance through altering ALS1 expression.
Title: Coordination between apoplastic and symplastic detoxification confers plant aluminum resistance.
The characterization of ALS1 using aluminum stress and map-based cloning is reported.
Title: Arabidopsis ALS1 encodes a root tip and stele localized half type ABC transporter required for root growth in an aluminum toxic environment.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001344283.1

Supported by ESTs:

NM_123266.8

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to aluminum ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plant-type vacuole	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
located_in vacuolar membrane	HDA more info	PubMed
located_in vacuole	HDA more info	PubMed
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transporter associated with antigen processing protein 2

NP_198720.2

transporter associated with antigen processing protein 2 (TAP2); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, transporter activity; INVOLVED IN: response to aluminum ion; LOCATED IN: vacuolar membrane, plasma membrane, vacuole, plant-type vacuole; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: P-glycoprotein 11 (TAIR:AT1G02520.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

15625460..15629835

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123266.8 → NP_198720.2 transporter associated with antigen processing protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198720.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WML0, Q8RY45, Q9FID4

UniProtKB/TrEMBL

A0A178UH61, A0A654G6G7

Conserved Domains (1) summary

TIGR00958
Location:45 → 631

3a01208; Conjugate Transporter-2 (CT2) Family protein
NM_001344283.1 → NP_001332027.1 transporter associated with antigen processing protein 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BFP2