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Ndel1 nudE neurodevelopment protein 1 like 1 [ Mus musculus (house mouse) ]

Gene ID: 83431, updated on 24-Apr-2022

Summary

Official Symbol
Ndel1provided by MGI
Official Full Name
nudE neurodevelopment protein 1 like 1provided by MGI
Primary source
MGI:MGI:1932915
See related
Ensembl:ENSMUSG00000018736 AllianceGenome:MGI:1932915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NUDEL; MITAP1; mNudel; mNudE-L; 2600006O07Rik
Summary
Enables identical protein binding activity and tubulin binding activity. Involved in several processes, including insulin receptor signaling pathway; lysosome localization; and regulation of plasma membrane bounded cell projection organization. Acts upstream of or within several processes, including cytoskeleton organization; generation of neurons; and transport along microtubule. Located in several cellular components, including axon hillock; cytoskeleton; and synaptic vesicle. Part of microtubule associated complex. Is expressed in several structures, including central nervous system; craniocervical region bone; integumental system; metanephros; and sensory organ. Orthologous to human NDEL1 (nudE neurodevelopment protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 44.1), ovary adult (RPKM 37.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ndel1 in Genome Data Viewer
Location:
11; 11 B3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68712260..68743961, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68821434..68853146, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68634936..68666633, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm213 Neighboring gene myosin, heavy polypeptide 10, non-muscle Neighboring gene predicted gene, 53684 Neighboring gene predicted gene, 53685 Neighboring gene ring finger protein 222 Neighboring gene ribosomal protein L26

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oligopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex radially oriented cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of chromosome localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inner cell mass cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lysosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic centrosome separation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mitotic centrosome separation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neurofilament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within nuclear membrane disassembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ruffle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retrograde axonal transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vesicle transport along microtubule IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon hillock IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in central region of growth cone ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of kinesin complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule organizing center IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in neurofilament cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear distribution protein nudE-like 1
Names
nuclear disribution gene E like
nuclear distribution gene E-like homolog 1
protein Nudel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363304.1NP_001350233.1  nuclear distribution protein nudE-like 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK146029, AL603662
    Conserved Domains (2) summary
    TIGR02168
    Location:24195
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam04880
    Location:135309
    NUDE_C; NUDE protein, C-terminal conserved region
  2. NM_001363305.1NP_001350234.1  nuclear distribution protein nudE-like 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL603662
    Conserved Domains (1) summary
    pfam04880
    Location:6142
    NUDE_C; NUDE protein, C-terminal conserved region
  3. NM_023668.3NP_076157.2  nuclear distribution protein nudE-like 1 isoform 1

    See identical proteins and their annotated locations for NP_076157.2

    Status: VALIDATED

    Source sequence(s)
    BC046796, BY124052, CJ092278
    Consensus CDS
    CCDS24870.1
    UniProtKB/Swiss-Prot
    Q9ERR1
    Related
    ENSMUSP00000018880.8, ENSMUST00000018880.14
    Conserved Domains (2) summary
    TIGR02168
    Location:24195
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam04880
    Location:135309
    NUDE_C; NUDE protein, C-terminal conserved region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68712260..68743961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246442.2XP_030102302.1  nuclear distribution protein nudE-like 1 isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:24195
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam04880
    Location:135309
    NUDE_C; NUDE protein, C-terminal conserved region