Ndel1 nudE neurodevelopment protein 1 like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndel1provided by MGI
Official Full Name: nudE neurodevelopment protein 1 like 1provided by MGI
Primary source: MGI:MGI:1932915
See related: Ensembl:ENSMUSG00000018736 AllianceGenome:MGI:1932915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NUDEL; MITAP1; mNudel; mNudE-L; 2600006O07Rik
Summary: Enables identical protein binding activity and tubulin binding activity. Involved in several processes, including insulin receptor signaling pathway; lysosome localization; and regulation of plasma membrane bounded cell projection organization. Acts upstream of or within several processes, including cytoskeleton organization; generation of neurons; and transport along microtubule. Located in several cellular components, including axon hillock; cytoskeleton; and synaptic vesicle. Part of microtubule associated complex. Is expressed in several structures, including central nervous system; craniocervical region bone; integumental system; metanephros; and sensory organ. Orthologous to human NDEL1 (nudE neurodevelopment protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 44.1), ovary adult (RPKM 37.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.09 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (68712260..68743961, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (68821434..68853146, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles for Ndel1 in keratin organization and desmosome function.
Title: Roles for Ndel1 in keratin organization and desmosome function.
Role of NDEL1 and VEGF/VEGFR-2 in Mouse Hippocampus After Status Epilepticus.
Title: Role of NDEL1 and VEGF/VEGFR-2 in Mouse Hippocampus After Status Epilepticus.
results highlight S-Nitrosylation as a key activity-dependent mechanism underlying neonatal brain maturation and suggest that reduction of S-Nitrosylation of NDEL1 acts as a pathological factor mediating neurodevelopmental abnormalities caused by maternal alcohol exposure
Title: Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.
This study showed that Ndel1 Maintain Postnatal CA1 Hippocampus Integrity in mice.
Title: Ndel1 and Reelin Maintain Postnatal CA1 Hippocampus Integrity.
Data indicate that NDEL1 is inducibly expressed in the adult nervous system, and signaling via the CREB/CRE transcriptional pathway is likely involved. Role of NDEL1 in neuronal migration and neurite outgrowth during development raises the interesting prospect that inducible NDEL1 in the mature nervous system could contribute to the well-characterized structural and functional plasticity resulting from repetitive seizures
Title: Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain.
NDEL1 facilitates the reversal of somatodendritic traansport in the proximal axon.
Title: Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment.
study provided comprehensive documentation of the expression patterns of Nde1 and Ndel1 in cultured cells as well as in mouse and human brains, and also highlighting that dosage effects of these two proteins might contribute to some cases of mental disorder
Title: The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system.
Results suggest that NDEL1 might interact with DISC1 to activate ERK signaling and function as a potential protective factor during the spontaneous seizure period after pilocarpine-induced status epilepticus
Title: NDEL1 was decreased in the CA3 region but increased in the hippocampal blood vessel network during the spontaneous seizure period after pilocarpine-induced status epilepticus.
Results show that LIS1 acts via the LIS1-NDEL1-dynein complex to regulate astral microtubule MT plus-ends dynamics and establish proper contacts of MTs with the cell cortex to ensure precise cell division.
Title: LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex.
Nuclear distribution element-like 1 (Ndel1 or Nudel) was firstly described as a regulator of the cytoskeleton in microtubule and intermediate filament dynamics and microtubule-based transport.
Title: Ndel1, Nudel (Noodle): flexible in the cell?

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ndel1 (e-PCR), detects polymorphism
- UniSTS:546883

Ndel1 (e-PCR), detects polymorphism
- UniSTS:499127

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables oligopeptidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex radially oriented cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in establishment of chromosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner cell mass cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in lysosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic centrosome separation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic centrosome separation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mitotic centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurofilament cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nuclear membrane disassembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within radial glia-guided pyramidal neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retrograde axonal transport	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle transport along microtubule	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon hillock	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in central region of growth cone	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule organizing center	IGI Inferred from Genetic Interaction more info	PubMed
located_in neurofilament cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear distribution protein nudE-like 1

Names: nuclear disribution gene E like; nuclear distribution gene E-like homolog 1; protein Nudel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363304.1 → NP_001350233.1 nuclear distribution protein nudE-like 1 isoform 2

Status: VALIDATED

Source sequence(s)

AK146029, AL603662

Conserved Domains (2) summary

TIGR02168
Location:24 → 195

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam04880
Location:135 → 309

NUDE_C; NUDE protein, C-terminal conserved region
NM_001363305.1 → NP_001350234.1 nuclear distribution protein nudE-like 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL603662

Conserved Domains (1) summary

pfam04880
Location:6 → 142

NUDE_C; NUDE protein, C-terminal conserved region
NM_023668.3 → NP_076157.2 nuclear distribution protein nudE-like 1 isoform 1

See identical proteins and their annotated locations for NP_076157.2

Status: VALIDATED

Source sequence(s)

BC046796, BY124052, CJ092278

Consensus CDS

CCDS24870.1

UniProtKB/Swiss-Prot

Q9D0Q4, Q9EPT6, Q9ERR1

Related

ENSMUSP00000018880.8, ENSMUST00000018880.14

Conserved Domains (2) summary

TIGR02168
Location:24 → 195

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam04880
Location:135 → 309

NUDE_C; NUDE protein, C-terminal conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

68712260..68743961 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246442.2 → XP_030102302.1 nuclear distribution protein nudE-like 1 isoform X1

UniProtKB/Swiss-Prot

Q9D0Q4, Q9EPT6, Q9ERR1

Conserved Domains (2) summary

TIGR02168
Location:24 → 195

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam04880
Location:135 → 309

NUDE_C; NUDE protein, C-terminal conserved region