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Ngrn neugrin, neurite outgrowth associated [ Mus musculus (house mouse) ]

Gene ID: 83485, updated on 21-Apr-2024

Summary

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Official Symbol
Ngrnprovided by MGI
Official Full Name
neugrin, neurite outgrowth associatedprovided by MGI
Primary source
MGI:MGI:1933212
See related
Ensembl:ENSMUSG00000047084 AllianceGenome:MGI:1933212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable rRNA binding activity. Predicted to be involved in positive regulation of mitochondrial translation. Predicted to act upstream of or within cell differentiation. Located in nucleus. Is expressed in several structures, including brain; heart; liver; metanephros; and spinal cord ventral horn. Orthologous to human NGRN (neugrin, neurite outgrowth associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 19.2), CNS E18 (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D2; 7 45.58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79910963..79915126)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80261215..80265378)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4940 Neighboring gene tubulin tyrosine ligase-like family, member 13 Neighboring gene STARR-positive B cell enhancer ABC_E2826 Neighboring gene vacuolar protein sorting 33B Neighboring gene STARR-positive B cell enhancer ABC_E2827 Neighboring gene RCC1 domain containing 1 Neighboring gene protein regulator of cytokinesis 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells. Ishigaki S, et al. Biochem Biophys Res Commun, 2000 Dec 20. PMID 11118320
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neugrin
Names
FI58Gm
m-Neugrin
neurite outgrowth-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031375.4 → NP_113552.3  neugrin precursor

    See identical proteins and their annotated locations for NP_113552.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the functional protein.
    Source sequence(s)
    AC109232, AI506588, AK083330, CJ154012
    Consensus CDS
    CCDS21393.2
    UniProtKB/Swiss-Prot
    Q8C401, Q99KS2, Q99PU9
    Related
    ENSMUSP00000113444.2, ENSMUST00000117989.2
    Conserved Domains (1) summary
    pfam06413
    Location:73 → 293
    Neugrin; Neugrin

RNA

  1. NR_028053.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) retains an intron in the 5' coding region, compared to variant 2. This variant is represented as non-coding because translation would be expected to begin at the 5'-most translation start codon, as used in variant 1, which has a strong Kozak signal. However, translation from this start site renders the transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not clear which, if any, protein may be expressed from this variant.
    Source sequence(s)
    AC109232, AI506588, AK083330
    Related
    ENSMUST00000138005.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79910963..79915126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KS2.3 GenPept UniProtKB/Swiss-Prot:Q99KS2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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