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ELO3 radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835098, updated on 7-Sep-2023

Summary

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Gene symbol
ELO3
Gene description
radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein
Primary source
Araport:AT5G50320
Locus tag
AT5G50320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtELP3; EAST1; ELONGATA 3; Elongator protein 3; ELP3; enhancer-of-asymmetric leaves-two 1; HAC8; HAG3; HISTONE ACETYLTRANSFERASE 8; HISTONE ACETYLTRANSFERASE OF THE GNAT FAMILY 3; MXI22.3; MXI22_3
Summary
A subunit of Elongator, a histone acetyl transferase complex, consisting of six subunits (ELP1#AeiELP6), that copurifies with the elongating RNAPII in yeast and humans. Three Arabidopsis thaliana genes, encoding homologs of the yeast Elongator subunits ELP1, ELP3 (histone acetyl transferase), and ELP4 are responsible for the narrow leaf phenotype in elongata mutants and for reduced root growth that results from a decreased cell division rate. Two lines with RNAi constructs directed against HAG3 grow normally and can produce root calli, but have defects in agrobacterium-mediated transformation.
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Genomic context

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Location:
chromosome: 5
Exon count:
9
Sequence:
Chromosome: 5; NC_003076.8 (20480626..20484945, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene pseudo Neighboring gene Protein kinase superfamily protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HAG3, a Histone Acetyltransferase, Affects UV-B Responses by Negatively Regulating the Expression of DNA Repair Enzymes and Sunscreen Content in Arabidopsis thaliana. Fina JP, et al. Plant Cell Physiol, 2015 Jul. PMID 25907565
  2. ELONGATA3 is required for shoot meristem cell cycle progression in Arabidopsis thaliana seedlings. Skylar A, et al. Dev Biol, 2013 Oct 15. PMID 23969312
  3. Elongator subunit 3 positively regulates plant immunity through its histone acetyltransferase and radical S-adenosylmethionine domains. Defraia CT, et al. BMC Plant Biol, 2013 Jul 16. PMID 23856002, Free PMC Article
  4. Histone H2B monoubiquitination is required to reach maximal transcript levels of circadian clock genes in Arabidopsis. Himanen K, et al. Plant J, 2012 Oct. PMID 22762858
  5. Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana. Kojima S, et al. Plant Cell Physiol, 2011 Aug. PMID 21700721

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that histone acetyltransferase HAG3, directly or indirectly, participates in UV-B-induced DNA damage repair and signaling.
    Title: HAG3, a Histone Acetyltransferase, Affects UV-B Responses by Negatively Regulating the Expression of DNA Repair Enzymes and Sunscreen Content in Arabidopsis thaliana.
  2. HDA14, ELP3 and the PP2A A-subunits A1, A2 and A3 all reside in both the nucleus and cytosol of the cell.
    Title: Arabidopsis thaliana histone deacetylase 14 (HDA14) is an α-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3.
  3. ELONGATA3 (ELO3) as a key regulator of meristem cell cycle activation in Arabidopsis.
    Title: ELONGATA3 is required for shoot meristem cell cycle progression in Arabidopsis thaliana seedlings.
  4. AtELP3 regulates plant immunity through its histone acetyltransferase and radical S-adenosylmethionine domains.
    Title: Elongator subunit 3 positively regulates plant immunity through its histone acetyltransferase and radical S-adenosylmethionine domains.
  5. Double mutants between hub1-1 and elongata (elo) showed an embryo-lethal phenotype, indicating a synergistic genetic interaction.
    Title: Histone H2B monoubiquitination is required to reach maximal transcript levels of circadian clock genes in Arabidopsis.
  6. ELO3 mediated establishment of leaf polarity independently of AS2 and the trans-acting small interfering RNA-related pathway.
    Title: Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana.
  7. Results conclude that yeast and plant Elongator (elp3/ELO3) share tRNA modification roles and propose that this function might be conserved in Elongator from all eukaryotic kingdoms of life.
    Title: Elongator function in tRNA wobble uridine modification is conserved between yeast and plants.
  8. show that the Elongator (elo1, elo2, and elo3) complex was purified from plant cell cultures as a six-component complex.
    Title: Plant Elongator regulates auxin-related genes during RNA polymerase II transcription elongation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_124412.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-mediated transformation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of auxin mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of leaf formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in specification of plant organ axis polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of elongator holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein
NP_568725.1
  • ELONGATA 3 (ELO3); CONTAINS InterPro DOMAIN/s: GCN5-related N-acetyltransferase, C-terminal (InterPro:IPR022610), GCN5-related N-acetyltransferase (InterPro:IPR000182), Elongator protein 3/MiaB/NifB (InterPro:IPR006638), Histone acetyltransferase ELP3 (InterPro:IPR005910), Radical SAM (InterPro:IPR007197), Acyl-CoA N-acyltransferase (InterPro:IPR016181); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    20480626..20484945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124412.3 → NP_568725.1  radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568725.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93ZR1, Q9FK40
    UniProtKB/TrEMBL
    A0A178UGS1, A0A5S9YF13, A0A7G2FJI4
    Conserved Domains (1) summary
    TIGR01211
    Location:39 → 564
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93ZR1.1

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