U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NBP35 nucleotide binding protein 35 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835169, updated on 7-Sep-2023

Summary

Go to the top of the page Help
Gene symbol
NBP35
Gene description
nucleotide binding protein 35
Primary source
Araport:AT5G50960
Locus tag
AT5G50960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATNBP35; K3K7.12; K3K7_12; nucleotide binding protein 35; NUCLEOTIDE BINDING PROTEIN 35
Summary
Highly similar to Saccharomyces cerevisiae NBP35, locus YGL091C. Cytosolic protein that homodimerizes and can assemble both 4Fe-4S - type and 2Fe-2S - type clusters on its amino terminal and carboxy therminal respectively. Null mutants are embryo lethal.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NBP35 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (20734136..20736138)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RNA-binding KH domain-containing protein Neighboring gene FUMARASE 2 Neighboring gene transducin family protein / WD-40 repeat family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Arabidopsis cytosolic Nbp35 homodimer can assemble both [2Fe-2S] and [4Fe-4S] clusters in two distinct domains. Kohbushi H, et al. Biochem Biophys Res Commun, 2009 Jan 23. PMID 19084504
  2. NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana. Bastow EL, et al. Plant J, 2017 Feb. PMID 27801963, Free PMC Article
  3. The essential cytosolic iron-sulfur protein Nbp35 acts without Cfd1 partner in the green lineage. Bych K, et al. J Biol Chem, 2008 Dec 19. PMID 18957412
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that NBP35 physically interacts with DRE2.
    Title: NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana.
  2. These data suggest that Nbp35 plays a pivotal role in iron-sulfur cluster assembly and delivery in the plant cell cytosol as a bifunctional molecular scaffold.
    Title: Arabidopsis cytosolic Nbp35 homodimer can assemble both [2Fe-2S] and [4Fe-4S] clusters in two distinct domains.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_124475.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP-dependent FeS chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nucleotide binding protein 35
NP_568748.1
  • nucleotide binding protein 35 (NBP35); CONTAINS InterPro DOMAIN/s: Mrp, conserved site (InterPro:IPR000808), ATPase-like, ParA/MinD (InterPro:IPR019591); BEST Arabidopsis thaliana protein match is: IND1(iron-sulfur protein required for NADH dehydrogenase)-like (TAIR:AT4G19540.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    20734136..20736138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124475.5 → NP_568748.1  nucleotide binding protein 35 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568748.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8H1Q2, Q9C5E1, Q9FI52
    UniProtKB/TrEMBL
    A0A178UBK9, A0A5S9YCX0
    Conserved Domains (1) summary
    pfam10609
    Location:58 → 343
    ParA; NUBPL iron-transfer P-loop NTPase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8H1Q2.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools