Dbnl drebrin-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dbnlprovided by RGD
Official Full Name: drebrin-likeprovided by RGD
Primary source: RGD:70941
See related: Ensembl:ENSRNOG00000012378 AllianceGenome:RGD:70941
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: abp1; Sh3p7
Summary: Enables protein C-terminus binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; nervous system development; and podosome assembly. Located in dendrite and postsynaptic density. Orthologous to human DBNL (drebrin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 257.6), Thymus (RPKM 171.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (84880085..84895122)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (80666115..80681155)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (86029335..86044364)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings reveal a novel signaling adaptor protein, HIP-55, which negatively regulates the beta-AR-mediated ERK proliferative pathway and Cardia Fibroblast proliferation.
Title: HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW527377 (e-PCR)
- UniSTS:246030

AW532217 (e-PCR)
- UniSTS:245566

D14Rat19 (e-PCR)
- UniSTS:118359

D14Mgh1 (e-PCR)
- UniSTS:119442

AI713198 (e-PCR)
- UniSTS:261278

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	TAS Traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rac protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within actin filament severing	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in podosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axon extension	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic spine morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	ISO Inferred from Sequence Orthology more info
located_in podosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in site of polarized growth	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: drebrin-like protein

Names: SH3 domain-containing protein 7; actin-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277211.1 → NP_001264140.1 drebrin-like protein isoform 1

See identical proteins and their annotated locations for NP_001264140.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

BC072483, JAXUCZ010000014

UniProtKB/Swiss-Prot

Q9JHL4, Q9JM66, Q9JM67, Q9JM74

UniProtKB/TrEMBL

A6IKP5

Related

ENSRNOP00000017375.7, ENSRNOT00000017375.8

Conserved Domains (2) summary

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

cd11960
Location:381 → 434

SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
NM_001277212.1 → NP_001264141.1 drebrin-like protein isoform 3

See identical proteins and their annotated locations for NP_001264141.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AB039819, JAXUCZ010000014

UniProtKB/TrEMBL

A6IKP5

Conserved Domains (2) summary

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

cd11960
Location:377 → 430

SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
NM_001277213.1 → NP_001264142.1 drebrin-like protein isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses two alternate splice sites in the coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.

Source sequence(s)

AB038364, JAXUCZ010000014

UniProtKB/TrEMBL

A6IKP5

Conserved Domains (3) summary

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

cd11960
Location:376 → 429

SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1

pfam15231
Location:229 → 348

VCX_VCY; Variable charge X/Y family
NM_031352.2 → NP_112642.1 drebrin-like protein isoform 2

See identical proteins and their annotated locations for NP_112642.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AB039819, BC072483, JAXUCZ010000014

UniProtKB/TrEMBL

A6IKP2, A6IKP5

Conserved Domains (3) summary

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

cd11960
Location:378 → 431

SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1

pfam15231
Location:229 → 350

VCX_VCY; Variable charge X/Y family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

84880085..84895122

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092499.2 → XP_038948427.1 drebrin-like protein isoform X1

Conserved Domains (1) summary

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
XM_039092500.2 → XP_038948428.1 drebrin-like protein isoform X2

Conserved Domains (1) summary

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
XM_039092501.2 → XP_038948429.1 drebrin-like protein isoform X3

Conserved Domains (1) summary

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)