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RASSF5 Ras association domain family member 5 [ Homo sapiens (human) ]

Gene ID: 83593, updated on 5-Mar-2024

Summary

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Official Symbol
RASSF5provided by HGNC
Official Full Name
Ras association domain family member 5provided by HGNC
Primary source
HGNC:HGNC:17609
See related
Ensembl:ENSG00000266094 MIM:607020; AllianceGenome:HGNC:17609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3
Summary
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 44.1), lymph node (RPKM 34.6) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
1q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206507531..206589448)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (205771712..205853623)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206680864..206762780)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene inhibitor of nuclear factor kappa B kinase subunit epsilon Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2401 Neighboring gene IKBKE antisense RNA 1 Neighboring gene uncharacterized LOC124904493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1754 Neighboring gene ribosomal protein L7a pseudogene 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206717516-206718060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206718061-206718603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206730813-206731313 Neighboring gene uncharacterized LOC124904494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206761431-206761931 Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:206775241-206776440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2411 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1760 Neighboring gene DYRK3 antisense RNA 1 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 3 Neighboring gene uncharacterized LOC124904496 Neighboring gene Sharpr-MPRA regulatory region 10950 Neighboring gene uncharacterized LOC124904495

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anticancer activities in lung adenocarcinoma. Singh A, et al. J Biol Chem, 2021 Dec. PMID 34717958, Free PMC Article
  2. The Emerging Roles of RASSF5 in Human Malignancy. Li S, et al. Anticancer Agents Med Chem, 2018. PMID 28356010
  3. RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma. Guo W, et al. Clin Exp Metastasis, 2015 Jan. PMID 25579665
  4. Decreased expression and aberrant methylation of RASSF5A correlates with malignant progression of gastric cardia adenocarcinoma. Han L, et al. Mol Carcinog, 2015 Dec. PMID 25420558
  5. RASSF5 inhibits growth and invasion and induces apoptosis in osteosarcoma cells through activation of MST1/LATS1 signaling. Zhou XH, et al. Oncol Rep, 2014 Oct. PMID 25109282

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anticancer activities in lung adenocarcinoma.
    Title: Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anticancer activities in lung adenocarcinoma.
  2. NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX.
    Title: NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX.
  3. REVIEW: elucidate the acknowledged structure, progress in the verified functions and research advances of RASSF5 and the probably relevant signaling pathways
    Title: The Emerging Roles of RASSF5 in Human Malignancy.
  4. Ubc9 is an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL.
    Title: Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.
  5. Hepatitis C virus uses NS5B to specifically suppress NORE1A, facilitating viral replication and elevated Ras signaling.
    Title: Nonstructural protein 5B promotes degradation of the NORE1A tumor suppressor to facilitate hepatitis C virus replication.
  6. Our study demonstrated that miR-214 expression was elevated and RASSF5 was down regulated in oral cancer. Moreover, miR-214 suppressed KB cell apoptosis through down regulation of RASSF5 expression
    Title: MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5.
  7. mCD40L-induced cell death mediated by NORE1A expression appeared to be independent of mCD40L-induced cell death mediated by sustained JNK activation since NORE1A inhibition did not affect JNK phosphorylation and vice versa
    Title: NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism.
  8. Ras induces the formation of a complex between NORE1A and the phosphatase PP1A, promoting the activation of the Rb tumor suppressor by dephosphorylation
    Title: Ras Regulates Rb via NORE1A.
  9. Down-regulation of RASSF5A and RASSF5C expression is a tumor-specific phenomenon.
    Title: Decreased expression and aberrant methylation of RASSF5A correlates with malignant progression of gastric cardia adenocarcinoma.
  10. RASSF5 expression is negatively correlated with distant metastasis of osteosarcoma, and RASSF5 may function as a tumor suppressor in OS cells through activation of the MST1/LATS1 pathway.
    Title: RASSF5 inhibits growth and invasion and induces apoptosis in osteosarcoma cells through activation of MST1/LATS1 signaling.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10823, MGC17344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lymphocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of lymphocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 5
Names
Rap1-binding protein
Ras association (RalGDS/AF-6) domain family 5
Ras association (RalGDS/AF-6) domain family member 5
Ras effector-like protein
new ras effector 1
novel Ras effector 1
regulator for cell adhesion and polarization enriched in lymphoid tissue
tumor suppressor RASSF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029062.2 RefSeqGene

    Range
    4986..86903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182663.4 → NP_872604.1  ras association domain-containing protein 5 isoform A

    See identical proteins and their annotated locations for NP_872604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as transcript A, represents the longest transcript and encodes the longest isoform (A), also known as NORE1A.
    Source sequence(s)
    AC244034, AK289861, AK291268, BC004270, CD367770
    Consensus CDS
    CCDS30998.1
    UniProtKB/Swiss-Prot
    A8K1E6, Q5SY32, Q8WWV9, Q8WWW0, Q8WXF4, Q9BT99
    UniProtKB/TrEMBL
    A8K5F3
    Related
    ENSP00000462099.1, ENST00000579436.7
    Conserved Domains (3) summary
    cd17220
    Location:207 → 362
    RA_RASSF5; Ras-associating (RA) domain of Ras-association domain family 5 (RASSF5)
    pfam16517
    Location:372 → 410
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cd20886
    Location:120 → 171
    C1_RASSF5; protein kinase C conserved region 1 (C1 domain) found in Ras association domain-containing protein 5 (RASSF5) and similar proteins

  2. NM_182664.4 → NP_872605.1  ras association domain-containing protein 5 isoform B

    See identical proteins and their annotated locations for NP_872605.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform B) is shorter and has a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC244034, AK289861, AK291268, AY062003, BC004270, CD367770
    Consensus CDS
    CCDS1463.1
    UniProtKB/TrEMBL
    A0A075B763
    Related
    ENSP00000462544.1, ENST00000580449.5
    Conserved Domains (2) summary
    cd00029
    Location:133 → 170
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:272 → 330
    UBQ; Ubiquitin-like proteins

  3. NM_182665.4 → NP_872606.1  ras association domain-containing protein 5 isoform C

    See identical proteins and their annotated locations for NP_872606.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as transcript B, differs in the 5' UTR, lacks a portion of the 5' coding region, and intiates translation at an alternate start codon, compared to variant 1. The resulting isoform (C), also known as NORE1B, is shorter and has a distinct N-terminus when compared to isoform A.
    Source sequence(s)
    AC244034, BC004270, BC042651, CD367770, DA370470
    Consensus CDS
    CCDS1464.1
    UniProtKB/TrEMBL
    A8K7M4
    Related
    ENSP00000462576.1, ENST00000577571.5
    Conserved Domains (2) summary
    cd17220
    Location:54 → 209
    RA_RASSF5; Ras-associating (RA) domain of Ras-association domain family 5 (RASSF5)
    pfam16517
    Location:218 → 257
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206507531..206589448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    205771712..205853623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031437.1: Suppressed sequence

    Description
    NM_031437.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWW0.1 GenPept UniProtKB/Swiss-Prot:Q8WWW0

Gene LinkOut

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