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TOPP2 type one serine/threonine protein phosphatase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836034, updated on 7-Sep-2023

Summary

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Gene symbol
TOPP2
Gene description
type one serine/threonine protein phosphatase 2
Primary source
Araport:AT5G59160
Locus tag
AT5G59160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MNC17.9; MNC17_9; PPO; PROTOPORPHYRINOGEN OXIDASE; type one serine/threonine protein phosphatase 2
Summary
Encodes the catalytic subunit of a Type 1 phosphoprotein Ser/Thr phosphatase, expressed in roots, shoots and flowers.
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Genomic context

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See TOPP2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
4
Sequence:
Chromosome: 5; NC_003076.8 (23879236..23881840)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene BTB/POZ domain-containing protein Neighboring gene RAB GTPase homolog A2D Neighboring gene Proline-rich extensin-like family protein Neighboring gene DNA-directed RNA polymerase II

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of multiple type 1 phosphoprotein phosphatases in Arabidopsis thaliana. Smith RD, et al. Plant Mol Biol, 1993 Jan. PMID 7678768
  2. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit. Templeton GW, et al. Biochem J, 2011 Apr 1. PMID 21222654
  3. Identification and functional characterization of inhibitor-3, a regulatory subunit of protein phosphatase 1 in plants. Takemiya A, et al. Plant Physiol, 2009 May. PMID 19329567, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001037026.1
NM_125306.2
NM_180887.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein dephosphorylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
part_of protein phosphatase type 1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
type one serine/threonine protein phosphatase 2
NP_001032103.1
  • type one serine/threonine protein phosphatase 2 (TOPP2); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 5 (TAIR:AT3G46820.1); Has 7217 Blast hits to 7021 proteins in 626 species: Archae - 78; Bacteria - 572; Metazoa - 2410; Fungi - 1415; Plants - 989; Viruses - 12; Other Eukaryotes - 1741 (source: NCBI BLink).
NP_200724.1
  • type one serine/threonine protein phosphatase 2 (TOPP2); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 5 (TAIR:AT3G46820.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
NP_851218.1
  • type one serine/threonine protein phosphatase 2 (TOPP2); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 5 (TAIR:AT3G46820.1); Has 7217 Blast hits to 7021 proteins in 626 species: Archae - 78; Bacteria - 572; Metazoa - 2410; Fungi - 1415; Plants - 989; Viruses - 12; Other Eukaryotes - 1741 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    23879236..23881840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180887.5 → NP_851218.1  type one serine/threonine protein phosphatase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851218.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48482, Q24JM8, Q94B57
    UniProtKB/TrEMBL
    A0A178UGI0, A0A384KLS9, A0A7G2ET45, B9DHU3
    Conserved Domains (1) summary
    cd07414
    Location:14 → 304
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

  2. NM_001037026.1 → NP_001032103.1  type one serine/threonine protein phosphatase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001032103.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48482, Q24JM8, Q94B57
    UniProtKB/TrEMBL
    A0A178UGI0, A0A384KLS9, A0A7G2ET45, B9DHU3
    Conserved Domains (1) summary
    cd07414
    Location:14 → 304
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

  3. NM_125306.2 → NP_200724.1  type one serine/threonine protein phosphatase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200724.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48482, Q24JM8, Q94B57
    UniProtKB/TrEMBL
    A0A178UGI0, A0A384KLS9, A0A7G2ET45, B9DHU3
    Conserved Domains (1) summary
    cd07414
    Location:14 → 304
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48482.1

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