APC1 Mitochondrial substrate carrier family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: APC1
Gene description: Mitochondrial substrate carrier family protein
Primary source: Araport:AT5G61810
Locus tag: AT5G61810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATP/phosphate carrier 1; MAC9.1; MAC9_1
Summary: Encodes a mitochondrial ATP-Mg/Pi transporter. Binds to calcium.
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Genomic context

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Location:: chromosome: 5

Exon count:: 4

Sequence:: Chromosome: 5; NC_003076.8 (24831574..24833984, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

direct measurements of Mg(2+), Mn(2+), Fe(2+), Zn(2+) and Cu(2+) showed that they are cotransported with ATP by both hAPCs and AtAPCs. It is likely that in vivo APCs transport free ATP and ATP-Mg complex to different degrees, and probably trace amounts of other Metals(2+) in complex with ATP. [APC1]
Title: Mitochondrial ATP-Mg/phosphate carriers transport divalent inorganic cations in complex with ATP.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001037044.2

Supported by ESTs:

NM_125575.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables AMP transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within ADP transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ADP transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within AMP transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ATP transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ATP transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ATP transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoatomic anion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nucleotide transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphate ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphate ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xenobiotic transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Mitochondrial substrate carrier family protein

NP_001032121.1

Mitochondrial substrate carrier family protein; FUNCTIONS IN: binding, calcium ion binding; INVOLVED IN: transport, transmembrane transport; LOCATED IN: mitochondrial inner membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Mitochondrial carrier protein (InterPro:IPR002067), EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Mitochondrial substrate carrier (InterPro:IPR001993), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: Mitochondrial substrate carrier family protein (TAIR:AT5G07320.1); Has 27340 Blast hits to 13937 proteins in 456 species: Archae - 0; Bacteria - 2; Metazoa - 11225; Fungi - 8377; Plants - 4746; Viruses - 5; Other Eukaryotes - 2985 (source: NCBI BLink).

NP_568940.1

Mitochondrial substrate carrier family protein; FUNCTIONS IN: binding, calcium ion binding; INVOLVED IN: transport, transmembrane transport; LOCATED IN: mitochondrial inner membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Mitochondrial substrate carrier (InterPro:IPR001993), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), Mitochondrial carrier protein (InterPro:IPR002067), EF-HAND 2 (InterPro:IPR018249), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: Mitochondrial substrate carrier family protein (TAIR:AT5G07320.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24831574..24833984 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125575.4 → NP_568940.1 Mitochondrial substrate carrier family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568940.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FLS8

UniProtKB/TrEMBL

A0A178UGX9, A0A5S9YGU7

Conserved Domains (2) summary

COG5126
Location:32 → 168

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

PTZ00169
Location:209 → 475

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
NM_001037044.2 → NP_001032121.1 Mitochondrial substrate carrier family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001032121.1

Status: REVIEWED

UniProtKB/TrEMBL

F4K509

Conserved Domains (3) summary

smart00054
Location:1 → 21

EFh; EF-hand, calcium binding motif

PTZ00169
Location:66 → 332

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:148 → 236

Mito_carr; Mitochondrial carrier protein