BON1 Calcium-dependent phospholipid-binding Copine family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: BON1
Gene description: Calcium-dependent phospholipid-binding Copine family protein
Primary source: Araport:AT5G61900
Locus tag: AT5G61900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BON; BONZAI 1; COPINE 1; CPN1; K22G18.2; K22G18_2
Summary: Encodes a plasma-membrane localized, copine-like protein, which is a member of a newly identified class of calcium-dependent, phospholipid binding proteins that are present in a wide range of organisms. Mutants exhibit temperature-sensitive growth defects and increased hypersensitive response where permissive conditions are low temperature (22 degrees Celsius) and low humidity. Gene is expressed at 22 but not at 28 (restrictive condition) degrees. Lethality of double mutants with BON3 can be partially suppressed by SNC1. Double mutants show defects in development that are genetically separable from hypersensitive/cell death response.
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Genomic context

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See BON1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 17

Sequence:: Chromosome: 5; NC_003076.8 (24855661..24859341, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BONZAI Proteins Control Global Osmotic Stress Responses in Plants.
Title: BONZAI Proteins Control Global Osmotic Stress Responses in Plants.
The crystal structure of Arabidopsis BON1 provides insights into the copine protein family.
Title: The crystal structure of Arabidopsis BON1 provides insights into the copine protein family.
This study indicates that ACA10/8 and BON1 physically interact on plasma membrane and function in the generation of cytosol calcium signatures that are critical for stomatal movement and impact plant immunity.
Title: Calcium Pumps and Interacting BON1 Protein Modulate Calcium Signature, Stomatal Closure, and Plant Immunity.
BON1 and BIR1 might modulate both PAMP- and R protein-triggered immune responses.
Title: BON1 interacts with the protein kinases BIR1 and BAK1 in modulation of temperature-dependent plant growth and cell death in Arabidopsis.
Requirement of calcium binding, myristoylation, and protein-protein interaction for the Copine BON1 function in Arabidopsis.
Title: Requirement of calcium binding, myristoylation, and protein-protein interaction for the Copine BON1 function in Arabidopsis.
BON1 and BON3 represses the transcript accumulation and/or protein activities of multiple resistance (R)-like genes.
Title: Multiple R-like genes are negatively regulated by BON1 and BON3 in arabidopsis.
Promoter deletion analysis identified a 280 bp segment of the BON1/CPN1 promoter as being required for pathogen-induced gene expression; the same promoter region was also required for calcium ionophore-induced gene expression
Title: Evidence that the BONZAI1/COPINE1 protein is a calcium- and pathogen-responsive defense suppressor.
Overexpression of BAP1 or BAP2 with their partner BON1 inhibits programmed cell death induced by pathogens, the proapoptotic gene BAX, and superoxide-generating paraquat.
Title: The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell death.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_125583.4

Supported by ESTs:

NM_203248.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular homeostasis	NAS Non-traceable Author Statement more info
acts_upstream_of_or_within negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	NAS Non-traceable Author Statement more info
acts_upstream_of_or_within positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cellular defense response	NAS Non-traceable Author Statement more info
acts_upstream_of_or_within response to humidity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to temperature stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: Calcium-dependent phospholipid-binding Copine family protein

NP_568944.1

BONZAI 1 (BON1); FUNCTIONS IN: calcium-dependent phospholipid binding; INVOLVED IN: in 7 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Copine (InterPro:IPR010734), C2 calcium-dependent membrane targeting (InterPro:IPR000008), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: DCD (Development and Cell Death) domain protein (TAIR:AT5G61910.4); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_974977.1

BONZAI 1 (BON1); FUNCTIONS IN: calcium-dependent phospholipid binding; INVOLVED IN: in 7 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Copine (InterPro:IPR010734), C2 calcium-dependent membrane targeting (InterPro:IPR000008), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: DCD (Development and Cell Death) domain protein (TAIR:AT5G61910.4); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24855661..24859341 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125583.4 → NP_568944.1 Calcium-dependent phospholipid-binding Copine family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568944.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q941L3, Q9FH53

UniProtKB/TrEMBL

A0A178UMR4

Conserved Domains (3) summary

cd04047
Location:197 → 300

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:48 → 170

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:309 → 564

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
NM_203248.2 → NP_974977.1 Calcium-dependent phospholipid-binding Copine family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974977.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q941L3, Q9FH53

UniProtKB/TrEMBL

A0A178UMR4

Conserved Domains (3) summary

cd04047
Location:197 → 300

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:48 → 170

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:309 → 564

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...