U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GTR2 Major facilitator superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836389, updated on 15-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
GTR2
Gene description
Major facilitator superfamily protein
Primary source
Araport:AT5G62680
Locus tag
AT5G62680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtNPF2.11; GLUCOSINOLATE TRANSPORTER-2; MRG21.10; MRG21_10; NPF2.11; NRT1/ PTR family 2.11
Summary
Encodes a high-affinity, proton-dependent glucosinolate-specific transporter that is crucial for the transport of both methionine- and tryptophan-derived glucosinolates to seeds.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 5
Exon count:
4
Sequence:
Chromosome: 5; NC_003076.8 (25165137..25168060, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene ncRNA Neighboring gene H[+]-ATPase 11 Neighboring gene tubulin beta chain 2 Neighboring gene tubulin beta chain 3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A Functional EXXEK Motif is Essential for Proton Coupling and Active Glucosinolate Transport by NPF2.11. Jørgensen ME, et al. Plant Cell Physiol, 2015 Dec. PMID 26443378, Free PMC Article
  2. Rhizosecretion of stele-synthesized glucosinolates and their catabolites requires GTR-mediated import in Arabidopsis. Xu D, et al. J Exp Bot, 2017 Jun 1. PMID 27702989, Free PMC Article
  3. Elucidating the role of transport processes in leaf glucosinolate distribution. Madsen SR, et al. Plant Physiol, 2014 Nov. PMID 25209984, Free PMC Article
  4. Upon bolting the GTR1 and GTR2 transporters mediate transport of glucosinolates to the inflorescence rather than roots. Andersen TG, et al. Plant Signal Behav, 2014. PMID 24481282, Free PMC Article
  5. NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds. Nour-Eldin HH, et al. Nature, 2012 Aug 23. PMID 22864417

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of glucosinolate (GLS) importers GTR1 and GTR2 inside the stele, along with earlier observations, suggest three possible routes of stele-synthesized aliphatic GLS after their synthesis: (i) GTR-dependent import to cells symplastically connected to cortical cells and rhizosphere; (ii) GTR-independent transport via xylem to the shoot; and (iii) GTR-dependent import to GLS-degrading myrosin cells at the cortex.
    Title: Rhizosecretion of stele-synthesized glucosinolates and their catabolites requires GTR-mediated import in Arabidopsis.
  2. Study demonstrates an essential role for E1X1X2E2K motif for accumulation of substrate by NPF2.11. [NPF2.11]
    Title: A Functional EXXEK Motif is Essential for Proton Coupling and Active Glucosinolate Transport by NPF2.11.
  3. GTR2 role of transport processes in leaf glucosinolate distribution
    Title: Elucidating the role of transport processes in leaf glucosinolate distribution.
  4. glucosinolate can specifically translocate from rosette and roots to inflorescence in a GTR1- and GTR2-dependent manner
    Title: Upon bolting the GTR1 and GTR2 transporters mediate transport of glucosinolates to the inflorescence rather than roots.
  5. GTR1 and GTR2 control the loading of glucosinolates from the apoplasm into the phloem. [GTR2]
    Title: NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

NM_125663.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables glucosinolate:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within glucosinolate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phloem glucosinolate loading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Major facilitator superfamily protein
NP_201074.1
  • Major facilitator superfamily protein; FUNCTIONS IN: transporter activity; INVOLVED IN: oligopeptide transport, response to karrikin; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oligopeptide transporter (InterPro:IPR000109), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: Major facilitator superfamily protein (TAIR:AT3G47960.1); Has 3769 Blast hits to 3614 proteins in 562 species: Archae - 0; Bacteria - 609; Metazoa - 518; Fungi - 366; Plants - 2162; Viruses - 0; Other Eukaryotes - 114 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    25165137..25168060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125663.4 → NP_201074.1  Major facilitator superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201074.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LV10
    UniProtKB/TrEMBL
    A0A178UEQ7, A0A5S9YGD8
    Conserved Domains (1) summary
    cd17416
    Location:50 → 589
    MFS_NPF1_2; NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LV10.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Tools