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RBP5 retinol binding protein 5 [ Homo sapiens (human) ]

Gene ID: 83758, updated on 3-Apr-2024

Summary

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Official Symbol
RBP5provided by HGNC
Official Full Name
retinol binding protein 5provided by HGNC
Primary source
HGNC:HGNC:15847
See related
Ensembl:ENSG00000139194 MIM:611866; AllianceGenome:HGNC:15847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRBP3; CRBPIII; HRBPiso; CRBP-III
Summary
The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. [provided by RefSeq, Jul 2016]
Expression
Biased expression in kidney (RPKM 131.3), liver (RPKM 58.1) and 3 other tissues See more
Orthologs
all
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Genomic context

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Location:
12p13.31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7115736..7130005, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7130477..7143159, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7276282..7282601, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7188509-7189008 Neighboring gene Sharpr-MPRA regulatory region 13442 Neighboring gene complement C1r Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:7260830-7262029 Neighboring gene complement C1r subcomponent like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7265863-7266364 Neighboring gene C1RL antisense RNA 1 Neighboring gene RNA, U6 small nuclear 485, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7283265-7283766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4199 Neighboring gene calsyntenin 3 Neighboring gene Sharpr-MPRA regulatory region 5519 Neighboring gene uncharacterized LOC124902869 Neighboring gene MPRA-validated peak1553 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7340767-7341268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7341269-7341768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7342139-7342855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7342856-7343571 Neighboring gene peroxisomal biogenesis factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma. Ho JC, et al. J Cancer Res Clin Oncol, 2007 Dec. PMID 17497168
  2. Evolution of the family of intracellular lipid binding proteins in vertebrates. Schaap FG, et al. Mol Cell Biochem, 2002 Oct. PMID 12479570
  3. Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. Folli C, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11274389, Free PMC Article
  4. A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. Kim JY, et al. Mol Cell, 2014 May 22. PMID 24793694, Free PMC Article
  5. A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. Maio N, et al. Cell Metab, 2017 Apr 4. PMID 28380382

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our study revealed that RBP5 down-regulation in HCC was associated with aggressive tumor features, suggesting an
    Title: Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables retinal binding IEA
Inferred from Electronic Annotation
more info
  
enables retinoid binding TAS
Traceable Author Statement
more info
 PubMed 
enables retinol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
retinol-binding protein 5
Names
cellular retinol-binding protein III
putative cellular retinol-binding protein CRBP III
retinol binding protein 5, cellular

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329454.2 → NP_001316383.1  retinol-binding protein 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC018653, AC233309

  2. NM_031491.4 → NP_113679.1  retinol-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_113679.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA912830, BC029355
    Consensus CDS
    CCDS8574.1
    UniProtKB/Swiss-Prot
    P82980, Q53FB1
    Related
    ENSP00000266560.3, ENST00000266560.8
    Conserved Domains (1) summary
    pfam00061
    Location:6 → 105
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    7115736..7130005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020002.2 → XP_016875491.1  retinol-binding protein 5 isoform X1

    Conserved Domains (1) summary
    pfam00061
    Location:14 → 92
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  2. XM_047429633.1 → XP_047285589.1  retinol-binding protein 5 isoform X2

    Related
    ENSP00000438083.1, ENST00000542370.1

RNA

  1. XR_007063133.1 RNA Sequence

  2. XR_001748882.2 RNA Sequence

  3. XR_007063132.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160008.1 Reference GRCh38.p14 PATCHES

    Range
    44978..57956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332544.1 → XP_054188519.1  retinol-binding protein 5 isoform X1

  2. XM_054332545.1 → XP_054188520.1  retinol-binding protein 5 isoform X2

RNA

  1. XR_008485780.1 RNA Sequence

  2. XR_008485778.1 RNA Sequence

  3. XR_008485779.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    7130477..7143159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373385.1 → XP_054229360.1  retinol-binding protein 5 isoform X1

  2. XM_054373386.1 → XP_054229361.1  retinol-binding protein 5 isoform X2

RNA

  1. XR_008488690.1 RNA Sequence

  2. XR_008488688.1 RNA Sequence

  3. XR_008488689.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82980.3 GenPept UniProtKB/Swiss-Prot:P82980

Gene LinkOut

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