Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nedd4lprovided by MGI
Official Full Name: neural precursor cell expressed, developmentally down-regulated gene 4-likeprovided by MGI
Primary source: MGI:MGI:1933754
See related: Ensembl:ENSMUSG00000024589 AllianceGenome:MGI:1933754
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nedd4b; NEDD4.2; Nedd4-2; 1300012C07Rik
Summary: Enables sodium channel inhibitor activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of systemic arterial blood pressure; regulation of bicellular tight junction assembly; and regulation of ion transport. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and retina. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 4.8), CNS E18 (RPKM 4.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 37.57 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (65017551..65350888)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (64884480..65217826)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.
Title: METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.
E3 ligase Nedd4L promotes macrophage M1 polarization and exacerbates brain damage by TRAF3/TBK1 signaling pathway after ICH in mice.
Title: E3 ligase Nedd4L promotes macrophage M1 polarization and exacerbates brain damage by TRAF3/TBK1 signaling pathway after ICH in mice.
Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.
Title: Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.
Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension.
Title: Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension.
Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.
Title: Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.
NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.
Title: NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.
A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis.
Title: A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis.
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2.
Title: E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2.
Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination.
Title: Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination.
E3 ubiquitin ligase Nedd4-2 exerts neuroprotective effects during endoplasmic reticulum stress.
Title: E3 ubiquitin ligase Nedd4-2 exerts neuroprotective effects during endoplasmic reticulum stress.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Gene trapped (1)
Targeted (8) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237824

NoName (e-PCR)
- UniSTS:237825

RH125948 (e-PCR)
- UniSTS:162660

RH126489 (e-PCR)
- UniSTS:163197

RH136323 (e-PCR)
- UniSTS:210314

RH127042 (e-PCR)
- UniSTS:209391

NoName (e-PCR)
- UniSTS:237823

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables potassium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sodium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cation channel activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of caveolin-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of sodium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of bicellular tight junction assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase NEDD4-like

Names: HECT-type E3 ubiquitin transferase NED4L; neural precursor cell expressed, developmentally down-regulated gene 4b

NP_001107858.1

EC 2.3.2.26

EC 2.3.2.36

NP_001390936.1

EC 2.3.2.26

EC 2.3.2.36

NP_001390937.1

EC 2.3.2.26

EC 2.3.2.36

NP_001390938.1

EC 2.3.2.26

EC 2.3.2.36

NP_001390942.1

EC 2.3.2.26

EC 2.3.2.36

NP_114087.2

EC 2.3.2.26

EC 2.3.2.36

XP_006526433.1

EC 2.3.2.26

EC 2.3.2.36

XP_006526434.1

EC 2.3.2.26

EC 2.3.2.36

XP_011245346.1

EC 2.3.2.26

EC 2.3.2.36

XP_011245349.1

EC 2.3.2.26

EC 2.3.2.36

XP_017173505.1

EC 2.3.2.26

EC 2.3.2.36

XP_030106497.1

EC 2.3.2.26

EC 2.3.2.36

XP_030106501.1

EC 2.3.2.26

EC 2.3.2.36

XP_030106502.1

EC 2.3.2.26

EC 2.3.2.36

XP_030106503.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017204.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017205.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017206.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017207.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017208.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017209.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017210.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017211.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017212.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017213.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017214.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017215.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017216.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017217.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017218.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017219.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017220.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017221.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017222.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017223.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017224.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017225.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017226.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017227.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017228.1

EC 2.3.2.26

EC 2.3.2.36

XP_036017229.1

EC 2.3.2.26

EC 2.3.2.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114386.2 → NP_001107858.1 E3 ubiquitin-protein ligase NEDD4-like isoform 1

Status: VALIDATED

Source sequence(s)

AC102288, AC102333, AC131709, AC161175

Consensus CDS

CCDS50309.1

UniProtKB/TrEMBL

A0A494BAG2, A0A494BAX0

Related

ENSMUSP00000158026.2, ENSMUST00000235343.2

Conserved Domains (6) summary

cd04033
Location:21 → 153

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:550 → 582

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:643 → 972

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:619 → 973

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:501 → 531

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:388 → 417

WW; WW domain
NM_001404007.1 → NP_001390936.1 E3 ubiquitin-protein ligase NEDD4-like isoform 3

Status: VALIDATED

Source sequence(s)

AC102288, AC102333, AC131709, AC161175

UniProtKB/TrEMBL

A0A494B953

Related

ENSMUSP00000157490.2, ENSMUST00000236736.2
NM_001404008.1 → NP_001390937.1 E3 ubiquitin-protein ligase NEDD4-like isoform 4

Status: VALIDATED

Source sequence(s)

AC102288, AC102333, AC161175

UniProtKB/TrEMBL

E9PXB7

Related

ENSMUSP00000157910.2, ENSMUST00000237854.2
NM_001404009.1 → NP_001390938.1 E3 ubiquitin-protein ligase NEDD4-like isoform 4

Status: VALIDATED

Source sequence(s)

AC102288, AC102333, AC161175

UniProtKB/TrEMBL

E9PXB7
NM_001404013.1 → NP_001390942.1 E3 ubiquitin-protein ligase NEDD4-like isoform 5

Status: VALIDATED

Source sequence(s)

AC102288, AC102333, AC161175

Related

ENSMUSP00000157658.2, ENSMUST00000236103.2
NM_031881.3 → NP_114087.2 E3 ubiquitin-protein ligase NEDD4-like isoform 2

See identical proteins and their annotated locations for NP_114087.2

Status: VALIDATED

Source sequence(s)

AC102288, AC102333, AC161175

Consensus CDS

CCDS29305.1

UniProtKB/TrEMBL

A0A286YCM8, G3X9H8, Q3TQK9

Related

ENSMUSP00000079280.5, ENSMUST00000080418.7

Conserved Domains (4) summary

smart00456
Location:429 → 461

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:522 → 851

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

65017551..65350888

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161323.1 → XP_036017216.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 479

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:540 → 869

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161333.1 → XP_036017226.1 E3 ubiquitin-protein ligase NEDD4-like isoform X19

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:409 → 459

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:520 → 849

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:247 → 276

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_030250641.1 → XP_030106501.1 E3 ubiquitin-protein ligase NEDD4-like isoform X20

UniProtKB/TrEMBL

E9PXB7, Q3TQK9

Conserved Domains (4) summary

smart00456
Location:409 → 441

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:502 → 831

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:247 → 276

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161325.1 → XP_036017218.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 479

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:540 → 869

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161334.1 → XP_036017227.1 E3 ubiquitin-protein ligase NEDD4-like isoform X19

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:409 → 459

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:520 → 849

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:247 → 276

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_030250643.1 → XP_030106503.1 E3 ubiquitin-protein ligase NEDD4-like isoform X20

UniProtKB/TrEMBL

E9PXB7, Q3TQK9

Conserved Domains (4) summary

smart00456
Location:409 → 441

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:502 → 831

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:247 → 276

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161324.1 → XP_036017217.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 479

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:540 → 869

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161332.1 → XP_036017225.1 E3 ubiquitin-protein ligase NEDD4-like isoform X19

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:409 → 459

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:520 → 849

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:247 → 276

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_030250642.1 → XP_030106502.1 E3 ubiquitin-protein ligase NEDD4-like isoform X20

UniProtKB/TrEMBL

E9PXB7, Q3TQK9

Conserved Domains (4) summary

smart00456
Location:409 → 441

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:502 → 831

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:247 → 276

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161336.1 → XP_036017229.1 E3 ubiquitin-protein ligase NEDD4-like isoform X21

UniProtKB/TrEMBL

A0A494B9L5

Conserved Domains (4) summary

smart00456
Location:259 → 291

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:352 → 681

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:77 → 103

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161321.1 → XP_036017214.1 E3 ubiquitin-protein ligase NEDD4-like isoform X13

UniProtKB/TrEMBL

A0A494BAX0

Conserved Domains (4) summary

cd04033
Location:8 → 140

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:537 → 587

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:648 → 977

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:375 → 404

WW; WW domain
XM_036161322.1 → XP_036017215.1 E3 ubiquitin-protein ligase NEDD4-like isoform X15

UniProtKB/TrEMBL

A0A494B9F0

Conserved Domains (4) summary

cd04033
Location:8 → 140

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:517 → 567

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:628 → 957

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:355 → 384

WW; WW domain
XM_030250637.1 → XP_030106497.1 E3 ubiquitin-protein ligase NEDD4-like isoform X16

UniProtKB/TrEMBL

A0A494B9F0

Conserved Domains (4) summary

cd04033
Location:8 → 140

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:517 → 549

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:610 → 939

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:355 → 384

WW; WW domain
XM_036161326.1 → XP_036017219.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 479

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:540 → 869

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161320.1 → XP_036017213.1 E3 ubiquitin-protein ligase NEDD4-like isoform X11

UniProtKB/TrEMBL

A0A494BAX0

Conserved Domains (4) summary

cd04033
Location:14 → 146

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:543 → 593

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:654 → 983

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:381 → 410

WW; WW domain
XM_036161327.1 → XP_036017220.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 479

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:540 → 869

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_011247044.3 → XP_011245346.1 E3 ubiquitin-protein ligase NEDD4-like isoform X18

See identical proteins and their annotated locations for XP_011245346.1

UniProtKB/TrEMBL

A0A286YCM8, G3X9H8, Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 461

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:522 → 851

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161335.1 → XP_036017228.1 E3 ubiquitin-protein ligase NEDD4-like isoform X19

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:409 → 459

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:520 → 849

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:247 → 276

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_011247047.3 → XP_011245349.1 E3 ubiquitin-protein ligase NEDD4-like isoform X20

UniProtKB/TrEMBL

E9PXB7, Q3TQK9

Conserved Domains (4) summary

smart00456
Location:409 → 441

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:502 → 831

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:247 → 276

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161318.1 → XP_036017211.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9

UniProtKB/TrEMBL

A0A494BAX0

Conserved Domains (4) summary

cd04033
Location:21 → 153

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:550 → 600

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:661 → 990

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:388 → 417

WW; WW domain
XM_036161319.1 → XP_036017212.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10

UniProtKB/TrEMBL

A0A494B9F0

Conserved Domains (4) summary

cd04033
Location:21 → 153

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:530 → 580

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:641 → 970

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:368 → 397

WW; WW domain
XM_036161328.1 → XP_036017221.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 479

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:540 → 869

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_006526370.4 → XP_006526433.1 E3 ubiquitin-protein ligase NEDD4-like isoform X7

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

cd04033
Location:67 → 179

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:576 → 608

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:669 → 998

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:414 → 443

WW; WW domain
XM_036161317.1 → XP_036017210.1 E3 ubiquitin-protein ligase NEDD4-like isoform X8

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

cd04033
Location:67 → 179

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:556 → 606

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:667 → 996

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:394 → 423

WW; WW domain
XM_006526371.4 → XP_006526434.1 E3 ubiquitin-protein ligase NEDD4-like isoform X12

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

cd04033
Location:67 → 179

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:556 → 588

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:649 → 978

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:394 → 423

WW; WW domain
XM_036161329.1 → XP_036017222.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 479

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:540 → 869

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161330.1 → XP_036017223.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 479

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:540 → 869

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_017318016.2 → XP_017173505.1 E3 ubiquitin-protein ligase NEDD4-like isoform X20

UniProtKB/TrEMBL

E9PXB7, Q3TQK9

Conserved Domains (4) summary

smart00456
Location:409 → 441

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:502 → 831

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:247 → 276

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_036161315.1 → XP_036017208.1 E3 ubiquitin-protein ligase NEDD4-like isoform X5

Conserved Domains (5) summary

smart00456
Location:647 → 697

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:758 → 1087

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03307
Location:83 → 316

PHA03307; transcriptional regulator ICP4; Provisional

pfam00397
Location:465 → 491

WW; WW domain

cl14603
Location:367 → 420

C2; C2 domain
XM_036161316.1 → XP_036017209.1 E3 ubiquitin-protein ligase NEDD4-like isoform X6

Conserved Domains (5) summary

smart00456
Location:647 → 679

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:740 → 1069

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03307
Location:83 → 316

PHA03307; transcriptional regulator ICP4; Provisional

pfam00397
Location:465 → 491

WW; WW domain

cl14603
Location:367 → 420

C2; C2 domain
XM_036161311.1 → XP_036017204.1 E3 ubiquitin-protein ligase NEDD4-like isoform X1

Conserved Domains (6) summary

smart00456
Location:817 → 867

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:928 → 1257

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03378
Location:107 → 318

PHA03378; EBNA-3B; Provisional

cd00201
Location:768 → 798

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:655 → 684

WW; WW domain

cl14603
Location:367 → 420

C2; C2 domain
XM_036161312.1 → XP_036017205.1 E3 ubiquitin-protein ligase NEDD4-like isoform X2

Conserved Domains (6) summary

smart00456
Location:817 → 849

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:910 → 1239

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03378
Location:107 → 318

PHA03378; EBNA-3B; Provisional

cd00201
Location:768 → 798

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:655 → 684

WW; WW domain

cl14603
Location:367 → 420

C2; C2 domain
XM_036161313.1 → XP_036017206.1 E3 ubiquitin-protein ligase NEDD4-like isoform X3

Conserved Domains (6) summary

smart00456
Location:797 → 847

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:908 → 1237

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03307
Location:83 → 316

PHA03307; transcriptional regulator ICP4; Provisional

cd00201
Location:748 → 778

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:635 → 664

WW; WW domain

cl14603
Location:367 → 420

C2; C2 domain
XM_036161314.1 → XP_036017207.1 E3 ubiquitin-protein ligase NEDD4-like isoform X4

Conserved Domains (6) summary

smart00456
Location:797 → 829

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:890 → 1219

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03307
Location:83 → 316

PHA03307; transcriptional regulator ICP4; Provisional

cd00201
Location:748 → 778

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:635 → 664

WW; WW domain

cl14603
Location:367 → 420

C2; C2 domain
XM_036161331.1 → XP_036017224.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17

UniProtKB/TrEMBL

Q3TQK9

Conserved Domains (4) summary

smart00456
Location:429 → 479

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:540 → 869

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:267 → 296

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain