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NRAMP6 NRAMP metal ion transporter 6 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838166, updated on 7-Sep-2023

Summary

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Gene symbol
NRAMP6
Gene description
NRAMP metal ion transporter 6
Primary source
Araport:AT1G15960
Locus tag
AT1G15960
See related
TAIR:AT1G15960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATNRAMP6; NRAMP metal ion transporter 6; T24D18.6; T24D18_6
Summary
member of Nramp2 family
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Genomic context

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See NRAMP6 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Sequence:
Chromosome: 1; NC_003070.9 (5481665..5486105, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein Neighboring gene Tudor/PWWP/MBT superfamily protein Neighboring gene ncRNA Neighboring gene cinnamoyl coa reductase 1 Neighboring gene DNA glycosylase superfamily protein Neighboring gene NDH-dependent cyclic electron flow 1 Neighboring gene cyclic nucleotide gated channel 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NRAMP6 and NRAMP1 cooperatively regulate root growth and manganese translocation under manganese deficiency in Arabidopsis. Li L, et al. Plant J, 2022 Jun. PMID 35365951
  2. The NRAMP6 metal transporter contributes to cadmium toxicity. Cailliatte R, et al. Biochem J, 2009 Aug 13. PMID 19545236
  3. Plasma membrane-associated calcium signaling modulates cadmium transport. Zhang Y, et al. New Phytol, 2023 Apr. PMID 36567524
  4. Phylogenetic relationships within cation transporter families of Arabidopsis. Mäser P, et al. Plant Physiol, 2001 Aug. PMID 11500563, Free PMC Article
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plasma membrane-associated calcium signaling modulates cadmium transport.
    Title: Plasma membrane-associated calcium signaling modulates cadmium transport.
  2. NRAMP6 functions as an intracellular metal transporter which contributes to the distribution of cadmium within the cell.
    Title: The NRAMP6 metal transporter contributes to cadmium toxicity.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_101464.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cadmium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inorganic anion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables manganese ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion transmembrane transporter activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cadmium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular monoatomic cation homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within metal ion transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to manganese starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NRAMP metal ion transporter 6
NP_173048.3
  • NRAMP metal ion transporter 6 (NRAMP6); FUNCTIONS IN: inorganic anion transmembrane transporter activity, metal ion transmembrane transporter activity; INVOLVED IN: cellular metal ion homeostasis, metal ion transport; LOCATED IN: membrane; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: LP.06 six leaves visible, LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage, LP.08 eight leaves visible; CONTAINS InterPro DOMAIN/s: Natural resistance-associated macrophage protein (InterPro:IPR001046); BEST Arabidopsis thaliana protein match is: natural resistance-associated macrophage protein 1 (TAIR:AT1G80830.1); Has 5518 Blast hits to 5467 proteins in 1679 species: Archae - 118; Bacteria - 4110; Metazoa - 356; Fungi - 271; Plants - 336; Viruses - 0; Other Eukaryotes - 327 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    5481665..5486105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101464.4 → NP_173048.3  NRAMP metal ion transporter 6 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173048.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q84N36, Q9C5V8, Q9S9N8
    UniProtKB/TrEMBL
    A0A5S9UPG8, A0A654EC90
    Conserved Domains (1) summary
    PRK00701
    Location:24 → 446
    PRK00701; divalent metal cation transporter MntH
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9S9N8.2

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