MMZ1 MMS ZWEI homologue 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: MMZ1
Gene description: MMS ZWEI homologue 1
Primary source: Araport:AT1G23260
Locus tag: AT1G23260
See related: TAIR:AT1G23260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F26F24.10; F26F24_10; MMS ZWEI homologue 1; UBIQUITIN E2 VARIANT 1A; UEV1A
Summary: MMZ1/UEV1A encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair by participating in lysine-63-based polyubiquitination reactions. UEV1A can form diubiquitin and triubiquitin chains in combination with UBC13A/UBC35 in vitro. It can also functionally complement an mms2 mutation in budding yeast, both by increasing mms2 mutant viability in the presence of the DNA damaging agent MMS, and by reducing the rate of spontaneous DNA mutation. However, a combination of MMZ1/UEV1A and UBC13A do not do a good job of rescuing an mms2 ubc13 double mutant in yeast. MMZ1/UEV1A transcripts are found at low levels in most plant organs, but cannot be detected in the pollen. Transcript levels do not appear to be stress-inducible. The uev1a-1 mutant shows normal sensitivity to MMS in germination assays suggesting that UEV1A is not required for DNA damage tolerance during this developmental stage.
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Genomic context

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See MMZ1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (8256854..8258725, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interestingly, all C-terminal tails in the Uev1A/B subfamily contain a putative prenylation motif, CaaX. Combined experimental results using AtUev1B demonstrated that it is most likely farnesylated and that its C-terminal tail, particularly the catalytic Cys residue in the CaaX motif, plays critical roles in protein-protein interaction, nuclear exclusion and membrane association.
Title: The C-terminal extension of Arabidopsis Uev1A/B with putative prenylation site plays critical roles in protein interaction, subcellular distribution and membrane association.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001332597.1

Supported by ESTs:

NM_102175.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within postreplication repair	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of UBC13-MMS2 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: MMS ZWEI homologue 1

NP_564191.1

MMS ZWEI homologue 1 (MMZ1); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: MMS ZWEI homologue 2 (TAIR:AT1G70660.1); Has 4438 Blast hits to 4438 proteins in 315 species: Archae - 0; Bacteria - 0; Metazoa - 2178; Fungi - 730; Plants - 896; Viruses - 0; Other Eukaryotes - 634 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

8256854..8258725 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102175.4 → NP_564191.1 MMS ZWEI homologue 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564191.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93YP0, Q9LR36

UniProtKB/TrEMBL

A0A178WAQ1, A0A5S9VM85

Conserved Domains (1) summary

smart00212
Location:15 → 150

UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
NM_001332597.1 → NP_001320610.1 MMS ZWEI homologue 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W8R0, A0A1P8AND1