PFA-DSP1 Phosphotyrosine protein phosphatases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: PFA-DSP1
Gene description: Phosphotyrosine protein phosphatases superfamily protein
Primary source: Araport:AT1G05000
Locus tag: AT1G05000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtPFA-DSP1; plant and fungi atypical dual-specificity phosphatase 1; T7A14.14; T7A14_14
Summary: Encodes an atypical dual-specificity phosphatase.
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Genomic context

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Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (1425539..1428869)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure of the protein product of the gene locus At1g05000, a hypothetical protein from A. thaliana, was determined by the multiple-wavelength anomalous diffraction method and was refined to an R factor of 20.4% (R(free) = 24.9%) at 3.3 A.
Title: Structural and functional characterization of a novel phosphatase from the Arabidopsis thaliana gene locus At1g05000.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001160832.2

Supported by ESTs:

NM_100379.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Phosphotyrosine protein phosphatases superfamily protein

NP_001154304.1

Phosphotyrosine protein phosphatases superfamily protein; FUNCTIONS IN: phosphatase activity, protein tyrosine phosphatase activity, phosphoprotein phosphatase activity; INVOLVED IN: dephosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Protein-tyrosine phosphatase, dual specificity phosphatase, eukaryotic (InterPro:IPR020428), Protein-tyrosine phosphatase, SIW14-like (InterPro:IPR004861); BEST Arabidopsis thaliana protein match is: Phosphotyrosine protein phosphatases superfamily protein (TAIR:AT2G32960.1); Has 580 Blast hits to 572 proteins in 119 species: Archae - 0; Bacteria - 14; Metazoa - 1; Fungi - 314; Plants - 145; Viruses - 0; Other Eukaryotes - 106 (source: NCBI BLink).

NP_171993.1

Phosphotyrosine protein phosphatases superfamily protein; FUNCTIONS IN: phosphatase activity, protein tyrosine phosphatase activity, phosphoprotein phosphatase activity; INVOLVED IN: dephosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Protein-tyrosine phosphatase, dual specificity phosphatase, eukaryotic (InterPro:IPR020428), Protein-tyrosine phosphatase, SIW14-like (InterPro:IPR004861); BEST Arabidopsis thaliana protein match is: Phosphotyrosine protein phosphatases superfamily protein (TAIR:AT2G32960.1); Has 669 Blast hits to 655 proteins in 149 species: Archae - 0; Bacteria - 50; Metazoa - 4; Fungi - 355; Plants - 145; Viruses - 0; Other Eukaryotes - 115 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

1425539..1428869

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001331513.1 → NP_001322400.1 Phosphotyrosine protein phosphatases superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WME5, A0A1P8ATV0
NM_001160832.2 → NP_001154304.1 Phosphotyrosine protein phosphatases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154304.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WMD7, A0A5S9SMT2, F4I780

Conserved Domains (1) summary

pfam03162
Location:53 → 234

Y_phosphatase2; Tyrosine phosphatase family
NM_100379.3 → NP_171993.1 Phosphotyrosine protein phosphatases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_171993.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WS70, Q9ZVN4

UniProtKB/TrEMBL

A0A178WMD7, A0A5S9SMT2

Conserved Domains (1) summary

cd14528
Location:52 → 199

PFA-DSP_Siw14; atypical dual specificity phosphatases similar to yeast Siw14