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Btbd1 BTB domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 83962, updated on 5-Mar-2024

Summary

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Official Symbol
Btbd1provided by MGI
Official Full Name
BTB domain containing 1provided by MGI
Primary source
MGI:MGI:1933765
See related
Ensembl:ENSMUSG00000025103 AllianceGenome:MGI:1933765
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190005H08Rik
Summary
Predicted to enable cullin family protein binding activity and identical protein binding activity. Predicted to be involved in neurogenesis. Predicted to act upstream of or within cell differentiation and muscle organ development. Located in P-body. Is expressed in several structures, including alimentary system; eye; immune system; liver and biliary system; and reproductive system. Orthologous to human BTBD1 (BTB domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 45.4), ovary adult (RPKM 21.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Btbd1 in Genome Data Viewer
Location:
7 D3; 7 45.71 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81441822..81479262, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81792074..81829498, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6568 Neighboring gene RIKEN cDNA 3110040N11 gene Neighboring gene RNA guanine-7 methyltransferase activating subunit Neighboring gene STARR-positive B cell enhancer ABC_E4944 Neighboring gene STARR-seq mESC enhancer starr_19371 Neighboring gene predicted gene, 32695 Neighboring gene predicted gene, 51491 Neighboring gene STARR-seq mESC enhancer starr_19372 Neighboring gene transmembrane 6 superfamily member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:89025770-89025983 Neighboring gene HDGF like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of BTBD1 in mesenchymal differentiation. Pisani DF, et al. Exp Cell Res, 2007 Jul 1. PMID 17462629
  2. The topoisomerase 1-interacting protein BTBD1 is essential for muscle cell differentiation. Pisani DF, et al. Cell Death Differ, 2004 Nov. PMID 15486563
  3. Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24. Carim-Todd L, et al. Gene, 2001 Jan 10. PMID 11179693
  4. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Xu L, et al. Exp Cell Res, 2003 Aug 1. PMID 12878161
  5. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-200b-5p inhibits tumor progression in salivary adenoid cystic carcinoma via targeting BTBD1.
    Title: MiR-200b-5p inhibits tumor progression in salivary adenoid cystic carcinoma via targeting BTBD1.
  2. BTBD1 is a key protein of balance between adipogenesis and myogenesis.
    Title: Involvement of BTBD1 in mesenchymal differentiation.
  3. BTBD1 is essential for myogenic differentiation
    Title: The topoisomerase 1-interacting protein BTBD1 is essential for muscle cell differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37676

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein 1
Names
BTB (POZ) domain containing 1
glucose signal-repressing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146193.2 → NP_666305.2  BTB/POZ domain-containing protein 1

    See identical proteins and their annotated locations for NP_666305.2

    Status: PROVISIONAL

    Source sequence(s)
    BC072618
    Consensus CDS
    CCDS21407.1
    UniProtKB/Swiss-Prot
    P58544, Q6GQU7, Q8BTZ0, Q8K0J0
    UniProtKB/TrEMBL
    Q5M8N6
    Related
    ENSMUSP00000026093.8, ENSMUST00000026093.9
    Conserved Domains (4) summary
    smart00225
    Location:94 → 181
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:193 → 292
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:68 → 177
    BTB; BTB/POZ domain
    pfam08005
    Location:340 → 486
    PHR; PHR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    81441822..81479262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541322.5 → XP_006541385.1  BTB/POZ domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    cd18346
    Location:53 → 185
    BTB_POZ_BTBD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1)
    pfam08005
    Location:340 → 358
    PHR; PHR domain
    cl28903
    Location:181 → 287
    BACK; BACK (BTB and C-terminal Kelch) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58544.3 GenPept UniProtKB/Swiss-Prot:P58544

Gene LinkOut

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