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MUR4 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839942, updated on 7-Sep-2023

Summary

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Gene symbol
MUR4
Gene description
NAD(P)-binding Rossmann-fold superfamily protein
Primary source
Araport:AT1G30620
Locus tag
AT1G30620
See related
TAIR:AT1G30620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
HIGH SUGAR RESPONSE8; HSR8; MURUS 4; T5I8.7; T5I8_7; UDP-D-XYLOSE 4-EPIMERASE 1; UXE1
Summary
encodes a type-II membrane protein that catalyzes 4-epimerization of UDP-D-Xylose to UDP-L-Arabinose in vitro, the nucleotide sugar used by glycosyltransferases in the arabinosylation of cell wall polysaccharides and wall-resident proteoglycans.
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Genomic context

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See MUR4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (10854517..10858280)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Subtilase family protein Neighboring gene pentatricopeptide (PPR) repeat-containing protein Neighboring gene Coatomer epsilon subunit Neighboring gene Protein kinase family protein Neighboring gene WRKY DNA-binding protein 14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Signaling from an altered cell wall to the nucleus mediates sugar-responsive growth and development in Arabidopsis thaliana. Li Y, et al. Plant Cell, 2007 Aug. PMID 17693536, Free PMC Article
  2. The biosynthesis of L-arabinose in plants: molecular cloning and characterization of a Golgi-localized UDP-D-xylose 4-epimerase encoded by the MUR4 gene of Arabidopsis. Burget EG, et al. Plant Cell, 2003 Feb. PMID 12566589, Free PMC Article
  3. The mur4 mutant of arabidopsis is partially defective in the de novo synthesis of uridine diphospho L-arabinose. Burget EG, et al. Plant Physiol, 1999 Oct. PMID 10517829, Free PMC Article
  4. Abscisic acid positively regulates l-arabinose metabolism to inhibit seed germination through ABSCISIC ACID INSENSITIVE4-mediated transcriptional promotions of MUR4 in Arabidopsis thaliana. Yan J, et al. New Phytol, 2020 Jan. PMID 31461539
  5. The Mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana. Seguela-Arnaud M, et al. BMC Plant Biol, 2015 Sep 5. PMID 26341899, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abscisic acid positively regulates l-arabinose metabolism to inhibit seed germination through ABSCISIC ACID INSENSITIVE4-mediated transcriptional promotions of MUR4 in Arabidopsis thaliana.
    Title: Abscisic acid positively regulates l-arabinose metabolism to inhibit seed germination through ABSCISIC ACID INSENSITIVE4-mediated transcriptional promotions of MUR4 in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001084163.1
NM_001332913.1
NM_001332914.1
NM_001332915.1
NM_001332916.1
NM_102799.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables UDP-arabinose 4-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose 4-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-L-arabinose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within arabinose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in capsule polysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within plant-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISM
Inferred from Sequence Model
more info
  
located_in Golgi trans cisterna HDA PubMed 

General protein information

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Preferred Names
NAD(P)-binding Rossmann-fold superfamily protein
NP_001077632.1
  • MURUS 4 (MUR4); FUNCTIONS IN: UDP-arabinose 4-epimerase activity, catalytic activity; INVOLVED IN: plant-type cell wall biogenesis, arabinose biosynthetic process, nucleotide-sugar metabolic process; LOCATED IN: Golgi apparatus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose 4-epimerase (InterPro:IPR005886); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT4G20460.1); Has 42706 Blast hits to 42698 proteins in 2964 species: Archae - 775; Bacteria - 25859; Metazoa - 727; Fungi - 574; Plants - 1159; Viruses - 34; Other Eukaryotes - 13578 (source: NCBI BLink).
NP_001319115.1
  • MURUS 4 (MUR4); FUNCTIONS IN: UDP-arabinose 4-epimerase activity, catalytic activity; INVOLVED IN: plant-type cell wall biogenesis, arabinose biosynthetic process, nucleotide-sugar metabolic process; LOCATED IN: Golgi apparatus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose 4-epimerase (InterPro:IPR005886); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT4G20460.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_174350.2
  • MURUS 4 (MUR4); FUNCTIONS IN: UDP-arabinose 4-epimerase activity, catalytic activity; INVOLVED IN: plant-type cell wall biogenesis, arabinose biosynthetic process, nucleotide-sugar metabolic process; LOCATED IN: Golgi apparatus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose 4-epimerase (InterPro:IPR005886); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT4G20460.1); Has 42820 Blast hits to 42812 proteins in 2971 species: Archae - 775; Bacteria - 25948; Metazoa - 715; Fungi - 615; Plants - 1158; Viruses - 34; Other Eukaryotes - 13575 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    10854517..10858280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102799.6 → NP_174350.2  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174350.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q570B0, Q8H7B9, Q9SA77
    UniProtKB/TrEMBL
    A0A178WAW9, A0A384K925, B9DGJ1
    Conserved Domains (1) summary
    cd05247
    Location:72 → 403
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

  2. NM_001084163.1 → NP_001077632.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077632.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8MR41
    Conserved Domains (2) summary
    cd05247
    Location:71 → 402
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
    TIGR01179
    Location:72 → 404
    galE; UDP-glucose-4-epimerase GalE

  3. NM_001332913.1 → NP_001319115.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q570B0, Q8H7B9, Q9SA77
    UniProtKB/TrEMBL
    A0A178WAW9, A0A384K925, B9DGJ1
    Conserved Domains (1) summary
    cd05247
    Location:72 → 403
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

  4. NM_001332914.1 → NP_001321845.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q570B0, Q8H7B9, Q9SA77
    UniProtKB/TrEMBL
    A0A178WAW9, A0A384K925, B9DGJ1
    Conserved Domains (1) summary
    cd05247
    Location:72 → 403
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

  5. NM_001332915.1 → NP_001321843.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AS43

  6. NM_001332916.1 → NP_001321844.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q570B0, Q8H7B9, Q9SA77
    UniProtKB/TrEMBL
    A0A178WAW9, A0A384K925, B9DGJ1
    Conserved Domains (1) summary
    cd05247
    Location:72 → 403
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SA77.1

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