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Mcam melanoma cell adhesion molecule [ Mus musculus (house mouse) ]

Gene ID: 84004, updated on 5-Apr-2024

Summary

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Official Symbol
Mcamprovided by MGI
Official Full Name
melanoma cell adhesion moleculeprovided by MGI
Primary source
MGI:MGI:1933966
See related
Ensembl:ENSMUSG00000032135 AllianceGenome:MGI:1933966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD146; CD149; Muc18; s-endo; 1-gicerin; s-gicerin
Summary
Predicted to be involved in angiogenesis and positive regulation of cell migration. Predicted to act upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in external side of plasma membrane; extracellular space; and nucleus. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human MCAM (melanoma cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 97.6), lung adult (RPKM 73.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Mcam in Genome Data Viewer
Location:
9 A5.1; 9 24.68 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44045958..44054024)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44134658..44142727)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23954 Neighboring gene ring finger protein 26 Neighboring gene STARR-seq mESC enhancer starr_23955 Neighboring gene predicted gene 10687 Neighboring gene STARR-seq mESC enhancer starr_23959 Neighboring gene Casitas B-lineage lymphoma Neighboring gene STARR-positive B cell enhancer ABC_E5062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44046702-44046855 Neighboring gene coiled-coil domain containing 153

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway. Zhang ZY, et al. PLoS One, 2022. PMID 36001597, Free PMC Article
  2. Ectopic expression of MCAM/MUC18 increases in vitro motility and invasiveness, but decreases in vivo tumorigenesis and metastasis of a mouse melanoma K1735-9 subline in a syngeneic mouse model. Wu GJ. Clin Exp Metastasis, 2016 Dec. PMID 27510563
  3. Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform. Stalin J, et al. Cardiovasc Res, 2016 Aug 1. PMID 27170199
  4. Impact of wall shear stress and ligand avidity on binding of anti-CD146-coated nanoparticles to murine tumor endothelium under flow. Thomann S, et al. Oncotarget, 2015 Nov 24. PMID 26503468, Free PMC Article
  5. CD146 mediates VEGF-induced melanoma cell extravasation through FAK activation. Jouve N, et al. Int J Cancer, 2015 Jul 1. PMID 25449773

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages.
    Title: CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages.
  2. Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling.
    Title: Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling.
  3. CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis.
    Title: CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis.
  4. Galphai1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
    Title: Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
  5. Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
    Title: Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
  6. CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis.
    Title: CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis.
  7. Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/beta-catenin pathway.
    Title: Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.
  8. The CD146-HIF-1alpha axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia.
    Title: The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia.
  9. Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.
    Title: Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.
  10. Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.
    Title: Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
cell surface glycoprotein MUC18
Names
gicerin
l-gicerin protein
melanoma adhesion molecule
melanoma-associated antigen MUC18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359530.2 → NP_001346459.1  cell surface glycoprotein MUC18 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC148328
    Consensus CDS
    CCDS90545.1
    Related
    ENSMUSP00000096451.3, ENSMUST00000098852.3
    Conserved Domains (4) summary
    pfam08205
    Location:141 → 236
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:348 → 412
    Ig_3; Immunoglobulin domain
    cl11960
    Location:34 → 120
    Ig; Immunoglobulin domain
    cl28434
    Location:440 → 517
    I-set; Immunoglobulin I-set domain

  2. NM_001421323.1 → NP_001408252.1  cell surface glycoprotein MUC18 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC148328

  3. NM_023061.3 → NP_075548.2  cell surface glycoprotein MUC18 isoform 1 precursor

    See identical proteins and their annotated locations for NP_075548.2

    Status: VALIDATED

    Source sequence(s)
    AC148328
    Consensus CDS
    CCDS23097.1
    UniProtKB/Swiss-Prot
    Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3
    Related
    ENSMUSP00000034650.9, ENSMUST00000034650.15
    Conserved Domains (5) summary
    smart00408
    Location:266 → 323
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:356 → 424
    IG_like; Immunoglobulin like
    pfam08205
    Location:141 → 236
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:351 → 427
    Ig_2; Immunoglobulin domain
    cl11960
    Location:452 → 509
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44045958..44054024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244742.2 → XP_030100602.1  cell surface glycoprotein MUC18 isoform X2

    Conserved Domains (4) summary
    smart00409
    Location:242 → 310
    IG; Immunoglobulin
    pfam08205
    Location:27 → 122
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:142 → 209
    Ig_3; Immunoglobulin domain
    cl11960
    Location:326 → 403
    Ig; Immunoglobulin domain

  2. XM_030244743.2 → XP_030100603.1  cell surface glycoprotein MUC18 isoform X3

    Conserved Domains (4) summary
    smart00409
    Location:242 → 310
    IG; Immunoglobulin
    pfam08205
    Location:27 → 122
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:142 → 209
    Ig_3; Immunoglobulin domain
    cl11960
    Location:326 → 403
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2Y2.1 GenPept UniProtKB/Swiss-Prot:Q8R2Y2

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