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Hao2 hydroxyacid oxidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84029, updated on 11-Apr-2024

Summary

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Official Symbol
Hao2provided by RGD
Official Full Name
hydroxyacid oxidase 2provided by RGD
Primary source
RGD:70972
See related
Ensembl:ENSRNOG00000019470 AllianceGenome:RGD:70972
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hao3; LCHAO
Summary
Enables (S)-2-hydroxy-acid oxidase activity; FMN binding activity; and identical protein binding activity. Involved in mandelate metabolic process. Located in peroxisome. Orthologous to human HAO2 (hydroxyacid oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 10819.9), Adrenal (RPKM 1700.4) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (188888848..188921567, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (186200137..186232997, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (200785492..200808868)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 Neighboring gene uncharacterized LOC120100894 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene small nucleolar RNA SNORA44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure analysis of recombinant rat kidney long chain hydroxy acid oxidase. Cunane LM, et al. Biochemistry, 2005 Feb 8. PMID 15683236
  2. Use of a panel of congenic strains to evaluate differentially expressed genes as candidate genes for blood pressure quantitative trait loci. Lee SJ, et al. Hypertens Res, 2003 Jan. PMID 12661916
  3. Molecular cloning and nucleotide sequence of cDNA encoding rat kidney long-chain L-2-hydroxy acid oxidase. Expression of the catalytically active recombinant protein as a chimaera. Belmouden A, et al. Eur J Biochem, 1993 May 15. PMID 8508789
  4. Rat kidney L-2-hydroxyacid oxidase. Structural and mechanistic comparison with flavocytochrome b2 from baker's yeast. Urban P, et al. Biochemistry, 1988 Sep 20. PMID 3061453
  5. Amino acid sequence of long chain alpha-hydroxy acid oxidase from rat kidney, a member of the family of FMN-dependent alpha-hydroxy acid-oxidizing enzymes. Diêp Lê KH, et al. J Biol Chem, 1991 Nov 5. PMID 1939137

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysregulation of HAO2 is a very early event in the development of hepatocellular carcinoma (HCC).
    Title: The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables (S)-2-hydroxy-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables (S)-2-hydroxy-acid oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (S)-2-hydroxy-acid oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables (S)-2-hydroxy-acid oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid alpha-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in mandelate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-Hydroxyacid oxidase 2
Names
(S)-2-hydroxy-acid oxidase, peroxisomal
HAOX2
hydroxyacid oxidase 2 (long chain)
hydroxyacid oxidase 3 (medium-chain)
long chain alpha-hydroxy acid oxidase
long-chain L-2-hydroxy acid oxidase
NP_114471.1
XP_006233084.1
XP_006233086.1
XP_006233087.1
XP_038959191.1
XP_063138713.1
XP_063138714.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032082.2 → NP_114471.1  2-Hydroxyacid oxidase 2

    See identical proteins and their annotated locations for NP_114471.1

    Status: PROVISIONAL

    Source sequence(s)
    X67156
    UniProtKB/Swiss-Prot
    Q07523
    UniProtKB/TrEMBL
    A0A0G2K713, A6K3E3
    Related
    ENSRNOP00000040223.1, ENSRNOT00000046942.3
    Conserved Domains (2) summary
    cd02809
    Location:7 → 345
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:14 → 349
    FMN_dh; FMN-dependent dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    188888848..188921567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282644.1 → XP_063138714.1  2-Hydroxyacid oxidase 2 isoform X5

    UniProtKB/Swiss-Prot
    Q07523
    UniProtKB/TrEMBL
    A6K3E3

  2. XM_039103263.2 → XP_038959191.1  2-Hydroxyacid oxidase 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K713
    Conserved Domains (1) summary
    pfam01070
    Location:13 → 352
    FMN_dh; FMN-dependent dehydrogenase

  3. XM_006233025.5 → XP_006233087.1  2-Hydroxyacid oxidase 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K713
    Conserved Domains (1) summary
    pfam01070
    Location:13 → 352
    FMN_dh; FMN-dependent dehydrogenase

  4. XM_006233024.5 → XP_006233086.1  2-Hydroxyacid oxidase 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K713
    Conserved Domains (2) summary
    cd02809
    Location:18 → 356
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:25 → 360
    FMN_dh; FMN-dependent dehydrogenase

  5. XM_063282643.1 → XP_063138713.1  2-Hydroxyacid oxidase 2 isoform X1

  6. XM_006233022.5 → XP_006233084.1  2-Hydroxyacid oxidase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K713, A0A8L2UQG3
    Related
    ENSRNOP00000071695.2
    Conserved Domains (2) summary
    cd02809
    Location:18 → 359
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:25 → 363
    FMN_dh; FMN-dependent dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07523.2 GenPept UniProtKB/Swiss-Prot:Q07523

Gene LinkOut

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