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FBP Inositol monophosphatase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840953, updated on 7-Sep-2023

Summary

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Gene symbol
FBP
Gene description
Inositol monophosphatase family protein
Primary source
Araport:AT1G43670
Locus tag
AT1G43670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
6-bisphosphatase; Arabidopsis thaliana cytosolic fructose-1; AtcFBP; F2J6.2; F2J6_2; FINS1; FRUCTOSE INSENSITIVE 1; fructose-1
Summary
Encodes a fructose-1,6-bisphosphatase. This enzyme, in addition to catalyzing the formation of fructose-6-phosphate for sucrose biosynthesis, appears to play a role in fructose-mediated signaling that is independent of its enzymatic activity. atcfbp-1/fins1 mutants have reduced photosynthetic rates, elevated levels of starch and reduced levels of sucrose during the day. Although the protein is expected to be cytosolic, a GFP-tagged version localizes to the cytoplasm and the nucleus.
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Genomic context

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See FBP in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (16467298..16470500)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FRUCTOSE INSENSITIVE1 regulates stem cell function in Arabidopsis in response to fructose signalling. Li Y, et al. J Exp Bot, 2023 May 19. PMID 36806617
  2. A FIT-binding protein is involved in modulating iron and zinc homeostasis in Arabidopsis. Chen CL, et al. Plant Cell Environ, 2018 Jul. PMID 29677391
  3. Loss of cytosolic fructose-1,6-bisphosphatase limits photosynthetic sucrose synthesis and causes severe growth retardations in rice (Oryza sativa). Lee SK, et al. Plant Cell Environ, 2008 Dec. PMID 18811733
  4. Decreased expression of two key enzymes in the sucrose biosynthesis pathway, cytosolic fructose-1,6-bisphosphatase and sucrose phosphate synthase, has remarkably different consequences for photosynthetic carbon metabolism in transgenic Arabidopsis thaliana. Strand A, et al. Plant J, 2000 Sep. PMID 10998187
  5. Signaling role of fructose mediated by FINS1/FBP in Arabidopsis thaliana. Cho YH, et al. PLoS Genet, 2011 Jan 6. PMID 21253566, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FRUCTOSE INSENSITIVE1 regulates stem cell function in Arabidopsis in response to fructose signalling.
    Title: FRUCTOSE INSENSITIVE1 regulates stem cell function in Arabidopsis in response to fructose signalling.
  2. involved in modulating iron and zinc homeostasis
    Title: A FIT-binding protein is involved in modulating iron and zinc homeostasis in Arabidopsis.
  3. FRUCTOSE INSENSITIVE 1 is an indispensable regulatory factor in the signaling pathway; its function in fructose signaling appears to be independent of its catalytic activity in sugar metabolism. [FRUCTOSE INSENSITIVE 1] [FINS1]
    Title: Signaling role of fructose mediated by FINS1/FBP in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_103492.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fructose 1,6-bisphosphate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within photosynthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to fructose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within starch catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sucrose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Inositol monophosphatase family protein
NP_175032.1
  • Inositol monophosphatase family protein; FUNCTIONS IN: fructose 1,6-bisphosphate 1-phosphatase activity, phosphoric ester hydrolase activity; INVOLVED IN: carbohydrate metabolic process, fructose metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Fructose-1,6-bisphosphatase, active site (InterPro:IPR020548), Fructose-1,6-bisphosphatase (InterPro:IPR000146); BEST Arabidopsis thaliana protein match is: high cyclic electron flow 1 (TAIR:AT3G54050.2); Has 3746 Blast hits to 3738 proteins in 1274 species: Archae - 47; Bacteria - 2330; Metazoa - 401; Fungi - 156; Plants - 330; Viruses - 0; Other Eukaryotes - 482 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    16467298..16470500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103492.5 → NP_175032.1  Inositol monophosphatase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175032.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9MA79
    UniProtKB/TrEMBL
    A0A178WCE5, A0A5S9WJX9, A0A7G2DYE2
    Conserved Domains (1) summary
    PLN02262
    Location:1 → 340
    PLN02262; fructose-1,6-bisphosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MA79.1

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