U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gpr87 G protein-coupled receptor 87 [ Mus musculus (house mouse) ]

Gene ID: 84111, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gpr87provided by MGI
Official Full Name
G protein-coupled receptor 87provided by MGI
Primary source
MGI:MGI:1934133
See related
Ensembl:ENSMUSG00000051431 AllianceGenome:MGI:1934133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human GPR87 (G protein-coupled receptor 87). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 4.8), limb E14.5 (RPKM 1.4) and 3 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gpr87 in Genome Data Viewer
Location:
3 D; 3 29.0 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (59086325..59102583, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59178904..59195163, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12-like Neighboring gene STARR-seq mESC enhancer starr_07762 Neighboring gene STARR-seq mESC enhancer starr_07763 Neighboring gene G protein-coupled receptor 171 Neighboring gene purinergic receptor P2Y, G-protein coupled, 14 Neighboring gene RIKEN cDNA F630111L10 gene Neighboring gene STARR-seq mESC enhancer starr_07764 Neighboring gene STARR-seq mESC enhancer starr_07765 Neighboring gene predicted gene, 51434 Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene purinergic receptor P2Y, G-protein coupled 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:59062055-59062302 Neighboring gene STARR-seq mESC enhancer starr_07766

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GPR87 promotes renal tubulointerstitial fibrosis by accelerating glycolysis and mitochondrial injury. Cui X, et al. Free Radic Biol Med, 2022 Aug 20. PMID 35843477
  2. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Tabata K, et al. Biochem Biophys Res Commun, 2007 Nov 23. PMID 17905198
  3. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. Wittenberger T, et al. J Mol Biol, 2001 Mar 30. PMID 11273702
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR87 promotes renal tubulointerstitial fibrosis by accelerating glycolysis and mitochondrial injury.
    Title: GPR87 promotes renal tubulointerstitial fibrosis by accelerating glycolysis and mitochondrial injury.
  2. Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y receptors.
    Title: The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G-protein coupled receptor 87

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302203.1 → NP_001289132.1  G-protein coupled receptor 87

    See identical proteins and their annotated locations for NP_001289132.1

    Status: VALIDATED

    Source sequence(s)
    AK080394, BB799918
    Consensus CDS
    CCDS79914.1
    UniProtKB/Swiss-Prot
    Q8C4Y7, Q99MT7
    UniProtKB/TrEMBL
    Q059H2
    Related
    ENSMUSP00000143683.2, ENSMUST00000200095.2
    Conserved Domains (2) summary
    pfam00001
    Location:60 → 314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57 → 173
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    59086325..59102583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502394.5 → XP_006502457.1  G-protein coupled receptor 87 isoform X1

    UniProtKB/TrEMBL
    Q059H2
    Conserved Domains (1) summary
    cd15969
    Location:34 → 316
    7tmA_GPR87; G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032399.1: Suppressed sequence

    Description
    NM_032399.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript may include intronic sequence at its 5' end.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MT7.2 GenPept UniProtKB/Swiss-Prot:Q99MT7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous