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Prl7d1 prolactin family 7, subfamily D, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84377, updated on 13-Apr-2024

Summary

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Official Symbol
Prl7d1provided by RGD
Official Full Name
prolactin family 7, subfamily D, member 1provided by RGD
Primary source
RGD:621307
See related
Ensembl:ENSRNOG00000016510 AllianceGenome:RGD:621307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PRP; Plfr
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 4.0) See more
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Genomic context

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See Prl7d1 in Genome Data Viewer
Location:
17p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (37191153..37261734)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (36982746..37053328)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (38993183..38999651)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene prolactin family 2, subfamily A, member 1 Neighboring gene prolactin family 7, subfamily c, member 1 Neighboring gene prolactin family 7, subfamily A, member 3 Neighboring gene prolactin family 7, subfamily A, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of proliferin-related protein in testis and the biological significance in testosterone production. Zhao L, et al. Mol Cell Endocrinol, 2011 Aug 22. PMID 21679748
  2. Identification of two new nonclassical members of the rat prolactin family. Sahgal N, et al. J Mol Endocrinol, 2000 Feb. PMID 10657001
  3. Identification of three prolactin-related hormones as markers of invasive trophoblasts in the rat. Toft DJ, et al. Biol Reprod, 2000 Aug. PMID 10906059
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that proliferin-related protein is regulated by HCG and plays roles in male reproduction, such as testosterone production.
    Title: Expression of proliferin-related protein in testis and the biological significance in testosterone production.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in placenta blood vessel development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prolactin-7D1
Names
proliferin related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053364.2 → NP_445816.1  prolactin-7D1 precursor

    See identical proteins and their annotated locations for NP_445816.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6J7Q5, F7F8M3, Q9R005
    Related
    ENSRNOP00000022251.3, ENSRNOT00000022251.7
    Conserved Domains (1) summary
    cd10288
    Location:30 → 239
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    37191153..37261734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096115.2 → XP_038952043.1  prolactin-7D1 isoform X1

    Conserved Domains (1) summary
    pfam00103
    Location:2 → 224
    Hormone_1; Somatotropin hormone family

  2. XM_039096116.2 → XP_038952044.1  prolactin-7D1 isoform X1

    Conserved Domains (1) summary
    pfam00103
    Location:2 → 224
    Hormone_1; Somatotropin hormone family

  3. XM_039096117.2 → XP_038952045.1  prolactin-7D1 isoform X1

    Conserved Domains (1) summary
    pfam00103
    Location:2 → 224
    Hormone_1; Somatotropin hormone family
Nucleotide Protein Strain
Heading Accession and Version

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