Il18bp interleukin 18 binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il18bpprovided by RGD
Official Full Name: interleukin 18 binding proteinprovided by RGD
Primary source: RGD:620042
See related: Ensembl:ENSRNOG00000020150 AllianceGenome:RGD:620042
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Igifbp
Summary: Predicted to enable interleukin-18 binding activity. Involved in cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in extracellular space. Human ortholog(s) of this gene implicated in allergic contact dermatitis and myocardial infarction. Orthologous to human IL18BP (interleukin 18 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 62.9), Heart (RPKM 54.4) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (165784916..165787990, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (156372923..156374963, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (167091521..167095727, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Remifentanil protects the liver against I/R injury by modulating hepatic IL-18/IL-18BP balance and inhibiting IL-18 signaling
Title: Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling.
This protein was isolated, cloned and characterized in cultured COS cells.
Title: Rat interleukin-18 binding protein: cloning, expression, and characterization.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables interleukin-18 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-18 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 1 type immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: interleukin-18-binding protein

Names: interferon gamma inducing factor binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053374.2 → NP_445826.2 interleukin-18-binding protein precursor

See identical proteins and their annotated locations for NP_445826.2

Status: VALIDATED

Source sequence(s)

AA925116, AF154569, CB809932, JAXUCZ010000001

UniProtKB/TrEMBL

A6I6Z8, Q9JLN2

Conserved Domains (1) summary

cl23951
Location:49 → 171

Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

165784916..165787990 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275803.1 → XP_063131873.1 interleukin-18-binding protein isoform X2
XM_008759805.4 → XP_008758027.1 interleukin-18-binding protein isoform X1

UniProtKB/TrEMBL

F7F5P4, Q9JLN2

Related

ENSRNOP00000027301.3

Conserved Domains (1) summary

cl23951
Location:49 → 166

Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein