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Smpx small muscle protein, X-linked [ Rattus norvegicus (Norway rat) ]

Gene ID: 84416, updated on 11-Apr-2024

Summary

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Official Symbol
Smpxprovided by RGD
Official Full Name
small muscle protein, X-linkedprovided by RGD
Primary source
RGD:69233
See related
AllianceGenome:RGD:69233
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in contractile fiber and nucleus. Predicted to be active in M band; costamere; and muscle tendon junction. Human ortholog(s) of this gene implicated in X-linked deafness 4. Orthologous to human SMPX (small muscle protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 2084.9) and Muscle (RPKM 713.7) See more
Orthologs
human mouse all
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Genomic context

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See Smpx in Genome Data Viewer
Location:
Xq21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (41049354..41107323, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (37233209..37292266, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (40029200..40086870, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene connector enhancer of kinase suppressor of Ras 2 Neighboring gene kelch-like family member 34 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene estrogen receptor binding site associated, antigen, 9, pseudogene 2 Neighboring gene membrane-bound transcription factor peptidase, site 2 Neighboring gene YY2 transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel stretch-responsive skeletal muscle gene (Smpx). Kemp TJ, et al. Genomics, 2001 Mar 15. PMID 11401441
  2. Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein. Patzak D, et al. Hum Genet, 1999 Nov. PMID 10598820
  3. The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner. Palmer S, et al. J Cell Biol, 2001 May 28. PMID 11381084, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in M band ISO
Inferred from Sequence Orthology
more info
  
located_in contractile muscle fiber ISO
Inferred from Sequence Orthology
more info
  
is_active_in costamere IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in costamere ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in muscle tendon junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in muscle tendon junction ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small muscular protein
Names
stretch-responsive skeletal muscle protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053395.1 → NP_445847.1  small muscular protein

    See identical proteins and their annotated locations for NP_445847.1

    Status: PROVISIONAL

    Source sequence(s)
    AF364071
    UniProtKB/Swiss-Prot
    Q925F0
    UniProtKB/TrEMBL
    A0A8L2Q474, A6IPP6
    Conserved Domains (1) summary
    pfam15355
    Location:1 → 84
    Chisel; Stretch-responsive small skeletal muscle X protein, Chisel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    41049354..41107323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256945.5 → XP_006257007.1  small muscular protein isoform X1

    See identical proteins and their annotated locations for XP_006257007.1

    UniProtKB/Swiss-Prot
    Q925F0
    UniProtKB/TrEMBL
    A0A8L2Q474, A6IPP6
    Conserved Domains (1) summary
    pfam15355
    Location:1 → 84
    Chisel; Stretch-responsive small skeletal muscle X protein, Chisel

RNA

  1. XR_005498074.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925F0.1 GenPept UniProtKB/Swiss-Prot:Q925F0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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