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Grb7 growth factor receptor bound protein 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84427, updated on 3-Apr-2024

Summary

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Official Symbol
Grb7provided by RGD
Official Full Name
growth factor receptor bound protein 7provided by RGD
Primary source
RGD:619759
See related
Ensembl:ENSRNOG00000006990 AllianceGenome:RGD:619759
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of translation; positive regulation of cell migration; and stress granule assembly. Predicted to be located in cytoplasmic stress granule; cytosol; and focal adhesion. Orthologous to human GRB7 (growth factor receptor bound protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 40.4), Liver (RPKM 28.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q31
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83936538..83949344)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83443387..83453057)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86393186..86408893)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene migration and invasion enhancer 1 Neighboring gene IKAROS family zinc finger 3 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134480865

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phase II Feasibility and Biomarker Study of Neoadjuvant Trastuzumab and Pertuzumab With Chemoradiotherapy for Resectable Human Epidermal Growth Factor Receptor 2-Positive Esophageal Adenocarcinoma: TRAP Study. Stroes CI, et al. J Clin Oncol, 2020 Feb 10. PMID 31809243, Free PMC Article
  2. Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas. Maqani N, et al. Mol Cancer Res, 2006 Jul. PMID 16849520
  3. Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma. Tanaka S, et al. J Cell Physiol, 2000 Jun. PMID 10797316
  4. GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma. Gotovac JR, et al. J Pathol, 2020 Nov. PMID 32737994, Free PMC Article
  5. Role of growth factor receptor bound protein 7 in hepatocellular carcinoma. Itoh S, et al. Mol Cancer Res, 2007 Jul. PMID 17634422

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EGF also activates focal adhesion kinase in the cytoplasm to rephosphorylate Grb7, releasing KOR mRNA for active translation.
    Title: Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93307

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in stress granule assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
growth factor receptor-bound protein 7
Names
GRB7 adapter protein
epidermal growth factor receptor GRB-7
growth factor receptor binding protein GRB7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053403.2 → NP_445855.1  growth factor receptor-bound protein 7

    See identical proteins and their annotated locations for NP_445855.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081757
    UniProtKB/Swiss-Prot
    Q9QZC5
    UniProtKB/TrEMBL
    A0A8I6AA75
    Related
    ENSRNOP00000090166.1, ENSRNOT00000117229.1
    Conserved Domains (4) summary
    cd10413
    Location:428 → 535
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:224 → 350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16140
    Location:102 → 186
    RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
    pfam08947
    Location:369 → 413
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    83936538..83949344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269991.1 → XP_063126061.1  growth factor receptor-bound protein 7 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZC5

  2. XM_039086969.2 → XP_038942897.1  growth factor receptor-bound protein 7 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZC5
    UniProtKB/TrEMBL
    A0A8I6AA75
    Conserved Domains (4) summary
    cd10413
    Location:428 → 535
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:224 → 350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16140
    Location:102 → 186
    RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
    pfam08947
    Location:369 → 413
    BPS; BPS (Between PH and SH2)

  3. XM_006247433.5 → XP_006247495.1  growth factor receptor-bound protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006247495.1

    UniProtKB/Swiss-Prot
    Q9QZC5
    UniProtKB/TrEMBL
    A0A8I6AA75
    Conserved Domains (4) summary
    cd10413
    Location:428 → 535
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:224 → 350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16140
    Location:102 → 186
    RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
    pfam08947
    Location:369 → 413
    BPS; BPS (Between PH and SH2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZC5.1 GenPept UniProtKB/Swiss-Prot:Q9QZC5

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