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NEURL4 neuralized E3 ubiquitin protein ligase 4 [ Homo sapiens (human) ]

Gene ID: 84461, updated on 5-Mar-2024

Summary

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Official Symbol
NEURL4provided by HGNC
Official Full Name
neuralized E3 ubiquitin protein ligase 4provided by HGNC
Primary source
HGNC:HGNC:34410
See related
Ensembl:ENSG00000215041 MIM:615865; AllianceGenome:HGNC:34410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 8.3), testis (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17p13.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7315628..7329335, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7219612..7233319, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7218947..7232654, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:7209261-7210072 and GRCh37_chr17:7210073-7210883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8105 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11610 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8107 Neighboring gene G protein pathway suppressor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7226660-7227166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7227167-7227672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7231927-7232586 Neighboring gene Sharpr-MPRA regulatory region 1992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7239291-7240052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7240053-7240814 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258016-7258542 Neighboring gene potassium channel tetramerization domain containing 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome. Loukil A, et al. J Cell Biol, 2017 May 1. PMID 28385950, Free PMC Article
  2. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. Cardamone MD, et al. J Cell Biol, 2022 Mar 7. PMID 35157000, Free PMC Article
  3. NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization. Cubillos-Rojas M, et al. Oncotarget, 2017 Sep 22. PMID 28977907, Free PMC Article
  4. Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2. García-Cano J, et al. Mol Oncol, 2020 Jan. PMID 31665549, Free PMC Article
  5. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. Li J, et al. EMBO Rep, 2012 Jun 1. PMID 22441691, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins.
    Title: Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins.
  2. The data support a model in which the daughter centriole promotes ciliogenesis through Neurl-4-dependent regulation of CP110 levels at the mother centriole.
    Title: The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome.
  3. the NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture
    Title: Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.
  4. Neurl4 counteracts accumulation of CP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centres
    Title: Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: GPS2

Homology

Clone Names

  • FLJ35680, KIAA1787

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuralized-like protein 4
Names
neuralized homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005408.2 → NP_001005408.1  neuralized-like protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame 6-nt segment in the coding region, as compared to variant 1. The encoded isoform 2 is thus slightly shorter than isoform 1.
    Source sequence(s)
    AB058690, AC026954, AL136870
    Consensus CDS
    CCDS42252.1
    UniProtKB/TrEMBL
    I3L2W2
    Related
    ENSP00000319826.7, ENST00000315614.11
    Conserved Domains (2) summary
    smart00588
    Location:316 → 437
    NEUZ; domain in neuralized proteins
    cd12887
    Location:718 → 880
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

  2. NM_032442.3 → NP_115818.2  neuralized-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_115818.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB058690, AC026954, AL136870
    Consensus CDS
    CCDS42251.1
    UniProtKB/Swiss-Prot
    Q6GPI8, Q96IU9, Q96JN8, Q9H0B0
    UniProtKB/TrEMBL
    I3L2W2
    Related
    ENSP00000382390.2, ENST00000399464.7
    Conserved Domains (2) summary
    smart00588
    Location:316 → 437
    NEUZ; domain in neuralized proteins
    cd12887
    Location:523 → 684
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7315628..7329335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p14 PATCHES

    Range
    73993..87700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7219612..7233319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96JN8.2 GenPept UniProtKB/Swiss-Prot:Q96JN8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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