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Cxcr3 C-X-C motif chemokine receptor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84475, updated on 30-Sep-2021

Summary

Official Symbol
Cxcr3provided by RGD
Official Full Name
C-X-C motif chemokine receptor 3provided by RGD
Primary source
RGD:621528
See related
EnsemblRapid:ENSRNOG00000003305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr9
Summary
binds interferon-inducible protein-10 and induces intracellular calcium mobilization; increased expression occurs in response to focal stroke [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 53.0), Thymus (RPKM 34.7) and 7 other tissues See more
Orthologs
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Genomic context

See Cxcr3 in Genome Data Viewer
Location:
Xq22
Exon count:
2
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (66844318..66846969, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (71614346..71616997, complement)

Chromosome X - NC_051356.1Genomic Context describing neighboring genes Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene retinitis pigmentosa 1-like 1 protein-like Neighboring gene 40S ribosomal protein S19-like Neighboring gene uncharacterized LOC102553785

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-X-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables C-X-C chemokine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables C-X-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables C-X-C chemokine receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 3
Names
CXC-R3
CXCR-3
G protein-coupled receptor 9
IP-10 receptor
chemokine (C-X-C motif) receptor 3
interferon-inducible protein 10 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053415.1NP_445867.1  C-X-C chemokine receptor type 3

    See identical proteins and their annotated locations for NP_445867.1

    Status: PROVISIONAL

    Source sequence(s)
    AF223642
    UniProtKB/Swiss-Prot
    Q9JII9
    Related
    ENSRNOP00000004406.3, ENSRNOT00000004406.6
    Conserved Domains (1) summary
    pfam00001
    Location:73317
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051356.1 Reference mRatBN7.2 Primary Assembly

    Range
    66844318..66846969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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