Slc24a2 solute carrier family 24 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc24a2provided by RGD
Official Full Name: solute carrier family 24 member 2provided by RGD
Primary source: RGD:628650
See related: Ensembl:ENSRNOG00000008169 AllianceGenome:RGD:628650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nckx2
Summary: Enables calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport and protein-containing complex assembly. Is intrinsic component of plasma membrane. Orthologous to human SLC24A2 (solute carrier family 24 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 315.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (106543867..106787810, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (101497916..101741840, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (105336287..105579959, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A critical role for miR135a5pmediated regulation of SLC24A2 in neuropathic pain.
Title: A critical role for miR‑135a‑5p‑mediated regulation of SLC24A2 in neuropathic pain.
Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
Title: Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
PKC-mediated activation of NCKX2 is sensitive to mutation of multiple PKC consensus sites via a mechanism that may involve several phosphorylation events
Title: Protein kinase C-dependent enhancement of activity of rat brain NCKX2 heterologously expressed in HEK293 cells.
topological studies of this protein in rat brain
Title: Topological studies of the rat brain K+-dependent Na+/Ca2+ exchanger NCKX2.
association as a dimer, an interaction that does not require, but may be stabilized by, a disulfide linkage through Cys-395
Title: A novel topology and redox regulation of the rat brain K+-dependent Na+/Ca2+ exchanger, NCKX2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE113849 (e-PCR)
- UniSTS:246818

AU048745 (e-PCR)
- UniSTS:145195

D5Got28 (e-PCR)
- UniSTS:113719

D5Wox41 (e-PCR)
- UniSTS:239950

D5Uwm23 (e-PCR)
- UniSTS:239977

BF415948 (e-PCR)
- UniSTS:248972

AI007603 (e-PCR)
- UniSTS:261568

D5Got31 (e-PCR)
- UniSTS:114400

AU047371 (e-PCR)
- UniSTS:110573

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium, potassium:sodium antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium, potassium:sodium antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium, potassium:sodium antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium, potassium:sodium antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium, potassium:sodium antiporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic depression	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term synaptic depression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/potassium/calcium exchanger 2

Names: Na(+)/K(+)/Ca(2+)-exchange protein 2; potassium-dependent sodium-calcium exchanger; retinal cone Na-Ca+K exchanger; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031743.4 → NP_113931.1 sodium/potassium/calcium exchanger 2

See identical proteins and their annotated locations for NP_113931.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O54701, O54706

UniProtKB/TrEMBL

A0A8I6GKF7, A6KRB1

Related

ENSRNOP00000010827.6, ENSRNOT00000010827.7

Conserved Domains (2) summary

TIGR00367
Location:138 → 652

TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein

pfam01699
Location:139 → 281

Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

106543867..106787810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288506.1 → XP_063144576.1 sodium/potassium/calcium exchanger 2 isoform X2
XM_063288505.1 → XP_063144575.1 sodium/potassium/calcium exchanger 2 isoform X2
XM_063288508.1 → XP_063144578.1 sodium/potassium/calcium exchanger 2 isoform X3
XM_063288507.1 → XP_063144577.1 sodium/potassium/calcium exchanger 2 isoform X3
XM_063288501.1 → XP_063144571.1 sodium/potassium/calcium exchanger 2 isoform X1

UniProtKB/Swiss-Prot

O54701, O54706

UniProtKB/TrEMBL

A6KRB1
XM_063288509.1 → XP_063144579.1 sodium/potassium/calcium exchanger 2 isoform X3
XM_063288503.1 → XP_063144573.1 sodium/potassium/calcium exchanger 2 isoform X1

UniProtKB/Swiss-Prot

O54701, O54706

UniProtKB/TrEMBL

A6KRB1
XM_063288502.1 → XP_063144572.1 sodium/potassium/calcium exchanger 2 isoform X1

UniProtKB/Swiss-Prot

O54701, O54706

UniProtKB/TrEMBL

A6KRB1
XM_063288504.1 → XP_063144574.1 sodium/potassium/calcium exchanger 2 isoform X1

UniProtKB/Swiss-Prot

O54701, O54706

UniProtKB/TrEMBL

A6KRB1
XM_063288510.1 → XP_063144580.1 sodium/potassium/calcium exchanger 2 isoform X4