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KDM2B lysine demethylase 2B [ Homo sapiens (human) ]

Gene ID: 84678, updated on 16-Apr-2024

Summary

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Official Symbol
KDM2Bprovided by HGNC
Official Full Name
lysine demethylase 2Bprovided by HGNC
Primary source
HGNC:HGNC:13610
See related
Ensembl:ENSG00000089094 MIM:609078; AllianceGenome:HGNC:13610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 6.6), appendix (RPKM 5.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12q24.31
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121408461..121582279, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121399894..121575445, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121866899..122018928, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121773208-121773399 Neighboring gene anaphase promoting complex subunit 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121789289-121789964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121790641-121791316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121791317-121791990 Neighboring gene uncharacterized LOC124903037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7164 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:121838029-121838560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121838561-121839092 Neighboring gene MPRA-validated peak2014 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7165 Neighboring gene ring finger protein 34 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121886380-121886880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121886881-121887381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121889913-121890727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121890728-121891541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4974 Neighboring gene microRNA 7107 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:121913999-121914826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121925323-121925834 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:121928205-121928918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121937748-121938447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121938448-121939146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121940397-121940896 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121951587-121951880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121953080-121953588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121953589-121954095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121956373-121956946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121967403-121967904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121971375-121972045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121973358-121974150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121984877-121985582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121987013-121987514 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122014140-122014717 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:122014718-122015296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4977 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122018218-122019153 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:122020089-122021024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122021025-122021958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122028863-122029678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122029679-122030494 Neighboring gene KDM2B divergent transcript Neighboring gene RNA, U6 small nuclear 1004, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4980 Neighboring gene Sharpr-MPRA regulatory region 5022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122062776-122063276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122070465-122071345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122076353-122076870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122076871-122077388 Neighboring gene ORAI calcium release-activated calcium modulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature. van Jaarsveld RH, et al. Genet Med, 2023 Jan. PMID 36322151, Free PMC Article
  2. Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors. Sasaki Y, et al. Biochem Biophys Res Commun, 2022 May 21. PMID 35306360
  3. Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway. Xie Z, et al. Bioengineered, 2021 Dec. PMID 34783291, Free PMC Article
  4. KDM2B is involved in the epigenetic regulation of TGF-β-induced epithelial-mesenchymal transition in lung and pancreatic cancer cell lines. Wanna-Udom S, et al. J Biol Chem, 2021 Jan-Jun. PMID 33779563, Free PMC Article
  5. The histone demethylase KDM2B regulates human primordial germ cell-like cells specification. Yuan W, et al. Int J Biol Sci, 2021. PMID 33613110, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4.
    Title: Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4.
  2. The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma.
    Title: The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma.
  3. KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma.
    Title: KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma.
  4. Biological Functions of the KDM2 Family of Histone Demethylases.
    Title: Biological Functions of the KDM2 Family of Histone Demethylases.
  5. Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature.
    Title: Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature.
  6. KDM2B mediates the Wnt/beta-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.
    Title: KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.
  7. Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors.
    Title: Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors.
  8. Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway.
    Title: Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway.
  9. SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation.
    Title: SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation.
  10. The histone demethylase KDM2B regulates human primordial germ cell-like cells specification.
    Title: The histone demethylase KDM2B regulates human primordial germ cell-like cells specification.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36me/H3K36me2 demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone demethylase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unmethylated CpG binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in embryonic camera-type eye morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in forebrain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fourth ventricle development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hindbrain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in initiation of neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lateral ventricle development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in midbrain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in midbrain-hindbrain boundary morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in protein demethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in third ventricle development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
  

General protein information

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Preferred Names
lysine-specific demethylase 2B
Names
CXXC-type zinc finger protein 2
F-box and leucine-rich repeat protein 10
F-box protein FBL10
F-box/LRR-repeat protein 10
JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein
[Histone-H3]-lysine-36 demethylase 1B
jmjC domain-containing histone demethylation protein 1B
jumonji C domain-containing histone demethylase 1B
lysine (K)-specific demethylase 2B
protein-containing CXXC domain 2
NP_001005366.1
NP_115979.3
XP_005254012.1
XP_005254013.1
XP_005254018.1
XP_011537169.2
XP_011537177.1
XP_047285637.1
XP_047285638.1
XP_047285639.1
XP_047285640.1
XP_047285641.1
XP_047285642.1
XP_047285643.1
XP_047285644.1
XP_047285645.1
XP_047285646.1
XP_047285647.1
XP_047285648.1
XP_047285649.1
XP_047285650.1
XP_047285651.1
XP_047285652.1
XP_047285653.1
XP_047285654.1
XP_047285655.1
XP_047285656.1
XP_047285657.1
XP_047285658.1
XP_047285659.1
XP_047285660.1
XP_047285661.1
XP_047285662.1
XP_047285663.1
XP_047285664.1
XP_047285665.1
XP_047285666.1
XP_047285667.1
XP_047285668.1
XP_047285669.1
XP_047285670.1
XP_047285671.1
XP_047285672.1
XP_047285673.1
XP_047285674.1
XP_047285675.1
XP_047285676.1
XP_047285677.1
XP_047285678.1
XP_047285679.1
XP_054229477.1
XP_054229478.1
XP_054229479.1
XP_054229480.1
XP_054229481.1
XP_054229482.1
XP_054229483.1
XP_054229484.1
XP_054229485.1
XP_054229486.1
XP_054229487.1
XP_054229488.1
XP_054229489.1
XP_054229490.1
XP_054229491.1
XP_054229492.1
XP_054229493.1
XP_054229494.1
XP_054229495.1
XP_054229496.1
XP_054229497.1
XP_054229498.1
XP_054229499.1
XP_054229500.1
XP_054229501.1
XP_054229502.1
XP_054229503.1
XP_054229504.1
XP_054229505.1
XP_054229506.1
XP_054229507.1
XP_054229508.1
XP_054229509.1
XP_054229510.1
XP_054229511.1
XP_054229512.1
XP_054229513.1
XP_054229514.1
XP_054229515.1
XP_054229516.1
XP_054229517.1
XP_054229518.1
XP_054229519.1
XP_054229520.1
XP_054229521.1
XP_054229522.1
XP_054229523.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033820.2 RefSeqGene

    Range
    6256..158183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005366.2 → NP_001005366.1  lysine-specific demethylase 2B isoform b

    See identical proteins and their annotated locations for NP_001005366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR and coding region, as compared to variant 1. The encoded isoform b has alternate N- and C-termini and lacks an internal segment, as compared to isoform a.
    Source sequence(s)
    AA504464, AK127328, BC028612
    Consensus CDS
    CCDS41849.1
    UniProtKB/Swiss-Prot
    Q8NHM5
    Related
    ENSP00000366269.3, ENST00000377069.8
    Conserved Domains (7) summary
    cd09293
    Location:1049 → 1238
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:151 → 226
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02008
    Location:584 → 620
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1033 → 1057
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:630 → 691
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam12937
    Location:999 → 1039
    F-box-like; F-box-like
    cl21464
    Location:198 → 304
    cupin_like; Conserved domain found in cupin and related proteins

  2. NM_032590.5 → NP_115979.3  lysine-specific demethylase 2B isoform a

    See identical proteins and their annotated locations for NP_115979.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC145422, AJ459424, AK027692, BX648928, CA430876
    Consensus CDS
    CCDS41850.1
    UniProtKB/Swiss-Prot
    A8MRS1, Q1RLM7, Q8NCI2, Q8NHM5, Q96HC7, Q96SL0, Q96T03, Q9NS96, Q9UF75
    Related
    ENSP00000366271.3, ENST00000377071.9
    Conserved Domains (7) summary
    cd09293
    Location:1118 → 1307
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:182 → 257
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02008
    Location:615 → 651
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1102 → 1126
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:661 → 722
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam12937
    Location:1068 → 1108
    F-box-like; F-box-like
    cl21464
    Location:229 → 335
    cupin_like; Conserved domain found in cupin and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    121408461..121582279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429682.1 → XP_047285638.1  lysine-specific demethylase 2B isoform X3

  2. XM_047429681.1 → XP_047285637.1  lysine-specific demethylase 2B isoform X2

  3. XM_011538867.4 → XP_011537169.2  lysine-specific demethylase 2B isoform X1

  4. XM_047429684.1 → XP_047285640.1  lysine-specific demethylase 2B isoform X5

  5. XM_047429683.1 → XP_047285639.1  lysine-specific demethylase 2B isoform X4

  6. XM_047429696.1 → XP_047285652.1  lysine-specific demethylase 2B isoform X17

  7. XM_047429690.1 → XP_047285646.1  lysine-specific demethylase 2B isoform X11

  8. XM_047429688.1 → XP_047285644.1  lysine-specific demethylase 2B isoform X9

  9. XM_047429707.1 → XP_047285663.1  lysine-specific demethylase 2B isoform X30

  10. XM_047429706.1 → XP_047285662.1  lysine-specific demethylase 2B isoform X29

  11. XM_047429716.1 → XP_047285672.1  lysine-specific demethylase 2B isoform X39

  12. XM_047429717.1 → XP_047285673.1  lysine-specific demethylase 2B isoform X39

  13. XM_047429708.1 → XP_047285664.1  lysine-specific demethylase 2B isoform X31

  14. XM_047429699.1 → XP_047285655.1  lysine-specific demethylase 2B isoform X20

  15. XM_047429698.1 → XP_047285654.1  lysine-specific demethylase 2B isoform X19

  16. XM_047429691.1 → XP_047285647.1  lysine-specific demethylase 2B isoform X12

  17. XM_047429693.1 → XP_047285649.1  lysine-specific demethylase 2B isoform X14

    UniProtKB/Swiss-Prot
    A8MRS1, Q1RLM7, Q8NCI2, Q8NHM5, Q96HC7, Q96SL0, Q96T03, Q9NS96, Q9UF75

  18. XM_047429705.1 → XP_047285661.1  lysine-specific demethylase 2B isoform X28

  19. XM_047429703.1 → XP_047285659.1  lysine-specific demethylase 2B isoform X26

  20. XM_047429692.1 → XP_047285648.1  lysine-specific demethylase 2B isoform X13

  21. XM_047429689.1 → XP_047285645.1  lysine-specific demethylase 2B isoform X10

  22. XM_047429687.1 → XP_047285643.1  lysine-specific demethylase 2B isoform X8

  23. XM_047429686.1 → XP_047285642.1  lysine-specific demethylase 2B isoform X7

  24. XM_047429685.1 → XP_047285641.1  lysine-specific demethylase 2B isoform X6

  25. XM_047429700.1 → XP_047285656.1  lysine-specific demethylase 2B isoform X21

  26. XM_047429709.1 → XP_047285665.1  lysine-specific demethylase 2B isoform X32

  27. XM_047429702.1 → XP_047285658.1  lysine-specific demethylase 2B isoform X24

  28. XM_005253955.5 → XP_005254012.1  lysine-specific demethylase 2B isoform X22

    Conserved Domains (7) summary
    cd09293
    Location:1087 → 1276
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:151 → 226
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02008
    Location:584 → 620
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1071 → 1095
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:630 → 691
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam12937
    Location:1037 → 1077
    F-box-like; F-box-like
    cl21464
    Location:198 → 304
    cupin_like; Conserved domain found in cupin and related proteins

  29. XM_047429694.1 → XP_047285650.1  lysine-specific demethylase 2B isoform X15

  30. XM_047429701.1 → XP_047285657.1  lysine-specific demethylase 2B isoform X23

  31. XM_047429711.1 → XP_047285667.1  lysine-specific demethylase 2B isoform X34

  32. XM_047429710.1 → XP_047285666.1  lysine-specific demethylase 2B isoform X33

  33. XM_047429704.1 → XP_047285660.1  lysine-specific demethylase 2B isoform X27

  34. XM_005253956.5 → XP_005254013.1  lysine-specific demethylase 2B isoform X25

    Conserved Domains (7) summary
    cd09293
    Location:1081 → 1270
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:145 → 220
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02008
    Location:578 → 614
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1065 → 1089
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:624 → 685
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam12937
    Location:1031 → 1071
    F-box-like; F-box-like
    cl21464
    Location:192 → 298
    cupin_like; Conserved domain found in cupin and related proteins

  35. XM_047429695.1 → XP_047285651.1  lysine-specific demethylase 2B isoform X16

  36. XM_047429697.1 → XP_047285653.1  lysine-specific demethylase 2B isoform X18

  37. XM_047429713.1 → XP_047285669.1  lysine-specific demethylase 2B isoform X36

  38. XM_047429715.1 → XP_047285671.1  lysine-specific demethylase 2B isoform X38

  39. XM_047429714.1 → XP_047285670.1  lysine-specific demethylase 2B isoform X37

  40. XM_047429712.1 → XP_047285668.1  lysine-specific demethylase 2B isoform X35

  41. XM_047429719.1 → XP_047285675.1  lysine-specific demethylase 2B isoform X40

  42. XM_047429720.1 → XP_047285676.1  lysine-specific demethylase 2B isoform X41

  43. XM_047429718.1 → XP_047285674.1  lysine-specific demethylase 2B isoform X40

  44. XM_047429723.1 → XP_047285679.1  lysine-specific demethylase 2B isoform X46

  45. XM_047429722.1 → XP_047285678.1  lysine-specific demethylase 2B isoform X45

  46. XM_047429721.1 → XP_047285677.1  lysine-specific demethylase 2B isoform X44

  47. XM_005253961.6 → XP_005254018.1  lysine-specific demethylase 2B isoform X43

    UniProtKB/TrEMBL
    B7ZB05
    Related
    ENSP00000437821.1, ENST00000542973.5
    Conserved Domains (5) summary
    cd09293
    Location:558 → 747
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:55 → 91
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:542 → 566
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:101 → 162
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam12937
    Location:508 → 548
    F-box-like; F-box-like

  48. XM_011538875.4 → XP_011537177.1  lysine-specific demethylase 2B isoform X42

    See identical proteins and their annotated locations for XP_011537177.1

    UniProtKB/TrEMBL
    B4DSN4, B7ZB05
    Conserved Domains (5) summary
    cd09293
    Location:561 → 750
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:55 → 91
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:545 → 569
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:101 → 162
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam12937
    Location:511 → 551
    F-box-like; F-box-like

RNA

  1. XR_007063140.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    121399894..121575445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373505.1 → XP_054229480.1  lysine-specific demethylase 2B isoform X3

  2. XM_054373503.1 → XP_054229478.1  lysine-specific demethylase 2B isoform X2

  3. XM_054373502.1 → XP_054229477.1  lysine-specific demethylase 2B isoform X1

  4. XM_054373514.1 → XP_054229489.1  lysine-specific demethylase 2B isoform X48

  5. XM_054373507.1 → XP_054229482.1  lysine-specific demethylase 2B isoform X5

  6. XM_054373506.1 → XP_054229481.1  lysine-specific demethylase 2B isoform X4

  7. XM_054373511.1 → XP_054229486.1  lysine-specific demethylase 2B isoform X9

  8. XM_054373519.1 → XP_054229494.1  lysine-specific demethylase 2B isoform X17

  9. XM_054373513.1 → XP_054229488.1  lysine-specific demethylase 2B isoform X11

  10. XM_054373504.1 → XP_054229479.1  lysine-specific demethylase 2B isoform X47

  11. XM_054373532.1 → XP_054229507.1  lysine-specific demethylase 2B isoform X30

  12. XM_054373531.1 → XP_054229506.1  lysine-specific demethylase 2B isoform X29

  13. XM_054373522.1 → XP_054229497.1  lysine-specific demethylase 2B isoform X20

  14. XM_054373521.1 → XP_054229496.1  lysine-specific demethylase 2B isoform X19

  15. XM_054373533.1 → XP_054229508.1  lysine-specific demethylase 2B isoform X31

  16. XM_054373515.1 → XP_054229490.1  lysine-specific demethylase 2B isoform X12

  17. XM_054373530.1 → XP_054229505.1  lysine-specific demethylase 2B isoform X28

  18. XM_054373528.1 → XP_054229503.1  lysine-specific demethylase 2B isoform X26

  19. XM_054373516.1 → XP_054229491.1  lysine-specific demethylase 2B isoform X13

  20. XM_054373512.1 → XP_054229487.1  lysine-specific demethylase 2B isoform X10

  21. XM_054373510.1 → XP_054229485.1  lysine-specific demethylase 2B isoform X8

  22. XM_054373509.1 → XP_054229484.1  lysine-specific demethylase 2B isoform X7

  23. XM_054373508.1 → XP_054229483.1  lysine-specific demethylase 2B isoform X6

  24. XM_054373523.1 → XP_054229498.1  lysine-specific demethylase 2B isoform X49

  25. XM_054373525.1 → XP_054229500.1  lysine-specific demethylase 2B isoform X50

  26. XM_054373534.1 → XP_054229509.1  lysine-specific demethylase 2B isoform X32

  27. XM_054373526.1 → XP_054229501.1  lysine-specific demethylase 2B isoform X24

  28. XM_054373524.1 → XP_054229499.1  lysine-specific demethylase 2B isoform X22

  29. XM_054373517.1 → XP_054229492.1  lysine-specific demethylase 2B isoform X15

  30. XM_054373527.1 → XP_054229502.1  lysine-specific demethylase 2B isoform X25

  31. XM_054373529.1 → XP_054229504.1  lysine-specific demethylase 2B isoform X27

  32. XM_054373535.1 → XP_054229510.1  lysine-specific demethylase 2B isoform X33

  33. XM_054373536.1 → XP_054229511.1  lysine-specific demethylase 2B isoform X34

  34. XM_054373518.1 → XP_054229493.1  lysine-specific demethylase 2B isoform X16

  35. XM_054373520.1 → XP_054229495.1  lysine-specific demethylase 2B isoform X18

  36. XM_054373538.1 → XP_054229513.1  lysine-specific demethylase 2B isoform X36

  37. XM_054373540.1 → XP_054229515.1  lysine-specific demethylase 2B isoform X38

  38. XM_054373539.1 → XP_054229514.1  lysine-specific demethylase 2B isoform X37

  39. XM_054373537.1 → XP_054229512.1  lysine-specific demethylase 2B isoform X35

  40. XM_054373542.1 → XP_054229517.1  lysine-specific demethylase 2B isoform X40

  41. XM_054373541.1 → XP_054229516.1  lysine-specific demethylase 2B isoform X40

  42. XM_054373543.1 → XP_054229518.1  lysine-specific demethylase 2B isoform X41

  43. XM_054373546.1 → XP_054229521.1  lysine-specific demethylase 2B isoform X44

  44. XM_054373545.1 → XP_054229520.1  lysine-specific demethylase 2B isoform X43

  45. XM_054373548.1 → XP_054229523.1  lysine-specific demethylase 2B isoform X46

  46. XM_054373547.1 → XP_054229522.1  lysine-specific demethylase 2B isoform X45

  47. XM_054373544.1 → XP_054229519.1  lysine-specific demethylase 2B isoform X42

    UniProtKB/TrEMBL
    B4DSN4

RNA

  1. XR_008488704.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NHM5.1 GenPept UniProtKB/Swiss-Prot:Q8NHM5

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