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C19orf48P chromosome 19 open reading frame 48, pseudogene [ Homo sapiens (human) ]

Gene ID: 84798, updated on 5-Mar-2024

Summary

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Official Symbol
C19orf48Pprovided by HGNC
Official Full Name
chromosome 19 open reading frame 48, pseudogeneprovided by HGNC
Gene description
multidrug resistance-related protein
Primary source
HGNC:HGNC:29667
See related
Ensembl:ENSG00000293495 MIM:618864; AllianceGenome:HGNC:29667
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf48; CA916798
Expression
Ubiquitous expression in prostate (RPKM 26.8), bone marrow (RPKM 14.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (50797704..50804594, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (53887193..53894085, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51300961..51307851, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372439 Neighboring gene small integral membrane protein 47 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14997 Neighboring gene acid phosphatase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14998 Neighboring gene small nucleolar RNA, C/D box 88B Neighboring gene small nucleolar RNA, C/D box 88A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51305278-51305778 Neighboring gene small nucleolar RNA, C/D box 88C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15001 Neighboring gene long intergenic non-protein coding RNA 1869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10980 Neighboring gene kallikrein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The human lung cancer drug resistance-related gene BC006151 regulates chemosensitivity in H446/CDDP cells. Li S, et al. Biol Pharm Bull, 2010. PMID 20686220
  2. C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients. Tykodi SS, et al. Clin Cancer Res, 2008 Aug 15. PMID 18698046, Free PMC Article
  3. [Cloning and sequence analysis of a new, full-length cDNA fragment of drug resistance-related gene in human lung adenocarcinoma]. Zhou XD, et al. Ai Zheng, 2002 Apr. PMID 12452007
  4. CA916798 affects growth and metastasis of androgen-dependent prostate cancer cells. He J, et al. Eur Rev Med Pharmacol Sci, 2018 Jul. PMID 30058677
  5. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. Andreev DE, et al. Elife, 2015 Jan 26. PMID 25621764, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study in prostate cancer (PCa) cell lines showed that AR could specifically bind to the promoter regions of the CA916798 (C19orf48). Results suggest that dihydrotestosterone could initiate the transcription of CA916798, which further mediates the androgen-AR signaling pathway-dependent cell growth and metastasis of the PCa, revealing CA916798 as a downstream target of AR in PCa.
    Title: CA916798 affects growth and metastasis of androgen-dependent prostate cancer cells.
  2. Donor T-cell responses against the HLA-A*0201-restricted minor H antigen encoded by C19orf48 may contribute to renal cell carcinoma regression after MHC-matched allogeneic hematopoietic cell transplantation
    Title: C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients.
  3. a new drug resistance-related gene closely related to MDR of lung adenocarcinama induced by CDDP.
    Title: [Cloning and sequence analysis of a new, full-length cDNA fragment of drug resistance-related gene in human lung adenocarcinoma].
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • multidrug resistance-related protein
  • uncharacterized protein C19orf48

Clone Names

  • MGC13170

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_171554.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325
    Related
    ENST00000597493.7

  2. NR_171555.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325

  3. NR_171556.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325
    Related
    ENST00000598463.5

  4. NR_171557.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325
    Related
    ENST00000597705.7

  5. NR_171558.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325

  6. NR_171559.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325
    Related
    ENST00000692421.1

  7. NR_171560.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325
    Related
    ENST00000596287.6

  8. NR_171561.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325
    Related
    ENST00000693315.1

  9. NR_171562.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325

  10. NR_171563.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010325
    Related
    ENST00000702900.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    50797704..50804594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    53887193..53894085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001290149.2: Suppressed sequence

    Description
    NM_001290149.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  2. NM_001290150.2: Suppressed sequence

    Description
    NM_001290150.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  3. NM_001290151.2: Suppressed sequence

    Description
    NM_001290151.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  4. NM_001290152.2: Suppressed sequence

    Description
    NM_001290152.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  5. NM_001290153.2: Suppressed sequence

    Description
    NM_001290153.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  6. NM_001290154.2: Suppressed sequence

    Description
    NM_001290154.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  7. NM_001290155.2: Suppressed sequence

    Description
    NM_001290155.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  8. NM_032712.3: Suppressed sequence

    Description
    NM_032712.3: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  9. NM_199249.3: Suppressed sequence

    Description
    NM_199249.3: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  10. NM_199250.3: Suppressed sequence

    Description
    NM_199250.3: This RefSeq was removed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version

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