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ZNF566 zinc finger protein 566 [ Homo sapiens (human) ]

Gene ID: 84924, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF566provided by HGNC
Official Full Name
zinc finger protein 566provided by HGNC
Primary source
HGNC:HGNC:25919
See related
Ensembl:ENSG00000186017 AllianceGenome:HGNC:25919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 1.9), ovary (RPKM 1.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF566 in Genome Data Viewer
Location:
19q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36445119..36489561, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39120063..39164789, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36936021..36980463, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZFP82 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36912605-36913287 Neighboring gene acyl-CoA thioesterase 4 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919277-36919778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919779-36920278 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:36939953-36941152 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36979559-36980446 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36980447-36981332 Neighboring gene ZNF566 antisense RNA 1 Neighboring gene CTBP2 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  2. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
  3. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14779, MGC12515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 566

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145343.1 → NP_001138815.1  zinc finger protein 566 isoform 2

    See identical proteins and their annotated locations for NP_001138815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting isoform (2) is one amino acid longer than isoform 1.
    Source sequence(s)
    AC092296, DC413210
    Consensus CDS
    CCDS46061.1
    UniProtKB/Swiss-Prot
    Q969W8
    Related
    ENSP00000400651.2, ENST00000427002.2
    Conserved Domains (6) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:254 → 405
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258 → 278
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:200 → 222
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:270 → 295
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001145344.1 → NP_001138816.1  zinc finger protein 566 isoform 1

    See identical proteins and their annotated locations for NP_001138816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC092295, AC092296, DC373988
    Consensus CDS
    CCDS12494.1
    UniProtKB/Swiss-Prot
    B7ZL95, Q2M3J1, Q969W8
    Related
    ENSP00000411526.2, ENST00000452939.7
    Conserved Domains (6) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    COG5048
    Location:253 → 404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199 → 221
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:269 → 294
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001145345.1 → NP_001138817.1  zinc finger protein 566 isoform 1

    See identical proteins and their annotated locations for NP_001138817.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC092296, BC104888, BP351422
    Consensus CDS
    CCDS12494.1
    UniProtKB/Swiss-Prot
    B7ZL95, Q2M3J1, Q969W8
    Related
    ENSP00000401259.2, ENST00000424129.7
    Conserved Domains (6) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    COG5048
    Location:253 → 404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199 → 221
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:269 → 294
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001300970.2 → NP_001287899.1  zinc finger protein 566 isoform 3

    See identical proteins and their annotated locations for NP_001287899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC092296, BC104888, BQ269572, DA116442, HY178567
    Consensus CDS
    CCDS74346.1
    UniProtKB/TrEMBL
    B4DRR6
    Conserved Domains (2) summary
    COG5048
    Location:149 → 300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:153 → 173
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_032838.4 → NP_116227.1  zinc finger protein 566 isoform 1

    See identical proteins and their annotated locations for NP_116227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC092296, AK027685
    Consensus CDS
    CCDS12494.1
    UniProtKB/Swiss-Prot
    B7ZL95, Q2M3J1, Q969W8
    Related
    ENSP00000415520.2, ENST00000434377.6
    Conserved Domains (6) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    COG5048
    Location:253 → 404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199 → 221
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:269 → 294
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36445119..36489561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527428.2 → XP_011525730.1  zinc finger protein 566 isoform X4

    See identical proteins and their annotated locations for XP_011525730.1

    UniProtKB/TrEMBL
    B4DRR6
    Related
    ENSP00000465343.1, ENST00000493391.6
    Conserved Domains (2) summary
    COG5048
    Location:149 → 300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:153 → 173
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_017027399.2 → XP_016882888.1  zinc finger protein 566 isoform X4

    UniProtKB/TrEMBL
    B4DRR6
    Conserved Domains (2) summary
    COG5048
    Location:149 → 300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:153 → 173
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_005259354.3 → XP_005259411.1  zinc finger protein 566 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:6 → 48
    KRAB; krueppel associated box
    COG5048
    Location:221 → 372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:225 → 245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:167 → 189
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:237 → 262
    zf-H2C2_2; Zinc-finger double domain

  4. XM_047439565.1 → XP_047295521.1  zinc finger protein 566 isoform X2

  5. XM_006723447.3 → XP_006723510.1  zinc finger protein 566 isoform X1

    See identical proteins and their annotated locations for XP_006723510.1

    UniProtKB/Swiss-Prot
    Q969W8
    Related
    ENSP00000376010.2, ENST00000392170.7
    Conserved Domains (6) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:254 → 405
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258 → 278
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:200 → 222
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:270 → 295
    zf-H2C2_2; Zinc-finger double domain

  6. XM_047439566.1 → XP_047295522.1  zinc finger protein 566 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39120063..39164789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322439.1 → XP_054178414.1  zinc finger protein 566 isoform X4

    UniProtKB/TrEMBL
    B4DRR6

  2. XM_054322438.1 → XP_054178413.1  zinc finger protein 566 isoform X4

    UniProtKB/TrEMBL
    B4DRR6

  3. XM_054322435.1 → XP_054178410.1  zinc finger protein 566 isoform X2

  4. XM_054322436.1 → XP_054178411.1  zinc finger protein 566 isoform X2

  5. XM_054322434.1 → XP_054178409.1  zinc finger protein 566 isoform X1

  6. XM_054322437.1 → XP_054178412.1  zinc finger protein 566 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969W8.1 GenPept UniProtKB/Swiss-Prot:Q969W8

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