RITA1 RBPJ interacting and tubulin associated 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RITA1provided by HGNC
Official Full Name: RBPJ interacting and tubulin associated 1provided by HGNC
Primary source: HGNC:HGNC:25925
See related: Ensembl:ENSG00000139405 MIM:620696; AllianceGenome:HGNC:25925
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RITA; C12orf52
Summary: Enables tubulin binding activity. Involved in negative regulation of Notch signaling pathway and nuclear export. Located in centrosome; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: RITA1 (Gene ID: 84934) and ZNF331 (Gene ID: 55422) share the RITA alias in common. RITA (Rearranged in Thyroid Adenomas) is a widely used alternative name for zinc finger protein 33 (ZNF331), which can be confused with the RITA alias used for RITA1, RBPJ-interacting and tubulin-associated protein 1 (RITA1). [22 Oct 2020]
Expression: Ubiquitous expression in kidney (RPKM 8.8), liver (RPKM 6.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (113185721..113192368)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (113162366..113168991)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (113623526..113630173)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ.
Title: RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ.
Data indicate that elevated levels of pretreatment RITA expression are correlated with unfavourable clinical outcome in anal carcinoma treated with concomitant chemoradiotherapy.
Title: Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy.
This study identifies RITA as a novel crucial player in cell migration and invasion by affecting the turnover of focal adhesions through its interference with the dynamics of actin filaments and microtubules. Its deregulation may contribute to malignant progression.
Title: RITA modulates cell migration and invasion by affecting focal adhesion dynamics.
RITA Is Expressed in Trophoblastic Cells and Is Involved in Differentiation Processes of the Placenta.
Title: RITA Is Expressed in Trophoblastic Cells and Is Involved in Differentiation Processes of the Placenta.
A potential role for RITA in the activation of Aurora A.
Title: Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis.
structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J.
Title: Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.
RITA overexpression increased expression of p53 and Fbxw7 and downregulated expression of cyclin D1, cyclin E, CDK2, Hes-1 and NF-kappaB p65. These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.
Title: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway.
human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly
Title: Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless.
RITA might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.
Title: RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-H97765 (e-PCR)
- UniSTS:3981

RH45703 (e-PCR)
- UniSTS:68000

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear export	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear export	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RBPJ-interacting and tubulin-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286215.2 → NP_001273144.1 RBPJ-interacting and tubulin-associated protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AA594422, AK027733, BX366456, DA207985

Consensus CDS

CCDS66473.1

UniProtKB/Swiss-Prot

Q96K30

Related

ENSP00000448680.1, ENST00000552495.1

Conserved Domains (1) summary

pfam17066
Location:27 → 293

RITA; RBPJ-interacting and tubulin associated protein
NM_032848.3 → NP_116237.1 RBPJ-interacting and tubulin-associated protein 1 isoform 1

See identical proteins and their annotated locations for NP_116237.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).

Source sequence(s)

AA594422, AK027733, DA207985

Consensus CDS

CCDS9166.1

UniProtKB/Swiss-Prot

B3KVZ4, C9JIN1, F8VRG5, Q53GM3, Q96K25, Q96K30

Related

ENSP00000449841.1, ENST00000548278.2

Conserved Domains (1) summary

pfam17066
Location:3 → 269

RITA; RBPJ-interacting and tubulin associated protein