U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PPFIBP2 PPFIA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 8495, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
PPFIBP2provided by HGNC
Official Full Name
PPFIA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:9250
See related
Ensembl:ENSG00000166387 MIM:603142; AllianceGenome:HGNC:9250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cclp1
Summary
This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 6.8) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PPFIBP2 in Genome Data Viewer
Location:
11p15.4
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (7513999..7667304)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (7572359..7725720)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (7535230..7679372)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene synaptotagmin 9 Neighboring gene Sharpr-MPRA regulatory region 13298 Neighboring gene NANOG hESC enhancer GRCh37_chr11:7472795-7473306 Neighboring gene SYT9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4363 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:7506414-7506918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4364 Neighboring gene leucine-rich repeat extensin-like protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4369 Neighboring gene MPRA-validated peak1190 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4370 Neighboring gene olfactomedin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4373 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:7584372-7584873 Neighboring gene uncharacterized LOC105376535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:7595102-7595926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:7595927-7596750 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:7599169-7599403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4374 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:7651972-7653171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4375 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:7672104-7673303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3111 Neighboring gene uncharacterized LOC105376533 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:7712245-7713444 Neighboring gene cytochrome b5 reductase 2 Neighboring gene uncharacterized LOC124902626 Neighboring gene ovochymase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Germline mutations in PPFIBP2 are associated with lethal prostate cancer. Wu Y, et al. Prostate, 2018 Dec. PMID 30043417
  2. Molecular markers of endometrial carcinoma detected in uterine aspirates. Colas E, et al. Int J Cancer, 2011 Nov 15. PMID 21207424
  3. Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Wang M, et al. Nat Commun, 2015 Oct 7. PMID 26443449, Free PMC Article
  4. Crystal structure of the central coiled-coil domain from human liprin-β2. Stafford RL, et al. Biochemistry, 2011 May 10. PMID 21462929, Free PMC Article
  5. Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells. Chiaretti S, et al. Biol Cell, 2016 Mar. PMID 26663347

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. germline mutations in a novel gene, PPFIBP2, differentiated risk for lethal prostate cancer from low-risk cases and were associated with shorter survival times after diagnosis.
    Title: Germline mutations in PPFIBP2 are associated with lethal prostate cancer.
  2. Analysis of the role of liprin-beta1 and liprin-beta2 has shown that while liprin-beta1 contributes positively to tumour cell motility in vitro; liprin-beta2 has a negative effect on both cell motility and invasion.
    Title: Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells.
  3. rs12791447 is associated with prostate cancer susceptibility in Asians. mRNA levels of PPFIBP2 are differentially expressed in prostate tumours and paired normal tissues.
    Title: Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
  4. Knockdown of either Rab17 or liprin-beta2 restores invasiveness of ERK2-depleted cells, indicating that ERK2 drives invasion of MDA-MB-231 cells by suppressing expression of these genes.
    Title: ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.
  5. analysis of crystal structure of the central coiled-coil domain from human liprin-beta2
    Title: Crystal structure of the central coiled-coil domain from human liprin-β2.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC42541, DKFZp781K06126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
liprin-beta-2
Names
PTPRF interacting protein, binding protein 2 (liprin beta 2)
liprin beta 2
protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256568.2 → NP_001243497.2  liprin-beta-2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC104237
    Consensus CDS
    CCDS58116.1
    UniProtKB/TrEMBL
    E9PP16
    Related
    ENSP00000435469.1, ENST00000528883.5
    Conserved Domains (4) summary
    cd09563
    Location:443 → 506
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:517 → 579
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:602 → 673
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:1 → 205
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001256569.2 → NP_001243498.2  liprin-beta-2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC104237
    Consensus CDS
    CCDS58117.1
    UniProtKB/TrEMBL
    E9PP16
    Related
    ENSP00000437321.1, ENST00000530181.5
    Conserved Domains (4) summary
    cd09563
    Location:412 → 475
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:486 → 548
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:571 → 642
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:26 → 212
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. NM_001351853.2 → NP_001338782.2  liprin-beta-2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC104237, AC107884
    Conserved Domains (4) summary
    cd09563
    Location:566 → 629
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:640 → 702
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:725 → 796
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:59 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. NM_001351854.2 → NP_001338783.2  liprin-beta-2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC104237, AC107884
    Conserved Domains (4) summary
    cd09563
    Location:555 → 618
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:629 → 691
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:714 → 785
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:59 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. NM_001351855.2 → NP_001338784.2  liprin-beta-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC104237, AC107884
    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (4) summary
    cd09563
    Location:566 → 629
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:640 → 702
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:725 → 796
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:59 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. NM_001351856.2 → NP_001338785.2  liprin-beta-2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC104237, AC107884
    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (4) summary
    cd09563
    Location:557 → 620
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:631 → 693
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:716 → 787
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:59 → 319
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. NM_001351857.2 → NP_001338786.2  liprin-beta-2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC104237, AC107884
    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (4) summary
    cd09563
    Location:489 → 552
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:563 → 625
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:648 → 719
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:14 → 240
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. NM_001351858.2 → NP_001338787.2  liprin-beta-2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC104237, AC107884
    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (4) summary
    cd09563
    Location:478 → 541
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:552 → 614
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:637 → 708
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:14 → 240
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. NM_001351859.2 → NP_001338788.2  liprin-beta-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC104237, AC107884
    Consensus CDS
    CCDS91429.1
    UniProtKB/TrEMBL
    A0A804HJY3, E9PP16
    Related
    ENSP00000507694.1, ENST00000684215.1
    Conserved Domains (4) summary
    cd09563
    Location:489 → 552
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:563 → 625
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:648 → 719
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:14 → 240
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  10. NM_001351860.2 → NP_001338789.2  liprin-beta-2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC104237, AC107884
    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (4) summary
    cd09563
    Location:486 → 549
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:560 → 622
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:645 → 716
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:36 → 248
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. NM_001351861.2 → NP_001338790.2  liprin-beta-2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC104237, AC107884
    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (4) summary
    cd09563
    Location:478 → 541
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:552 → 614
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:637 → 708
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:14 → 240
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. NM_001351862.2 → NP_001338791.2  liprin-beta-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC104237, AC107884
    Consensus CDS
    CCDS31419.1
    UniProtKB/Swiss-Prot
    B7Z433, E9PK77, O75337, Q8ND30, Q8WW26
    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (4) summary
    cd09563
    Location:555 → 618
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:629 → 691
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:714 → 785
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:59 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  13. NM_003621.5 → NP_003612.3  liprin-beta-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 13, encodes isoform 1.
    Source sequence(s)
    AC104237, AC107884
    Consensus CDS
    CCDS31419.1
    UniProtKB/Swiss-Prot
    B7Z433, E9PK77, O75337, Q8ND30, Q8WW26
    UniProtKB/TrEMBL
    E9PP16
    Related
    ENSP00000299492.4, ENST00000299492.9
    Conserved Domains (4) summary
    cd09563
    Location:555 → 618
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:629 → 691
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:714 → 785
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:59 → 317
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. NR_147792.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC104237, AC107884

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    7513999..7667304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520415.4 → XP_011518717.1  liprin-beta-2 isoform X3

    Conserved Domains (7) summary
    cd09563
    Location:566 → 629
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:640 → 702
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:725 → 796
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:566 → 630
    SAM; Sterile alpha motif
    pfam01519
    Location:110 → 161
    DUF16; Protein of unknown function DUF16
    pfam15290
    Location:212 → 366
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    pfam15774
    Location:321 → 470
    DUF4702; Domain of unknown function (DUF4702)

  2. XM_047427751.1 → XP_047283707.1  liprin-beta-2 isoform X5

  3. XM_011520413.3 → XP_011518715.1  liprin-beta-2 isoform X1

    See identical proteins and their annotated locations for XP_011518715.1

    UniProtKB/TrEMBL
    A0A804HKA2
    Conserved Domains (7) summary
    cd09563
    Location:566 → 629
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:640 → 702
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:725 → 796
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:566 → 630
    SAM; Sterile alpha motif
    pfam01519
    Location:110 → 161
    DUF16; Protein of unknown function DUF16
    pfam15290
    Location:212 → 366
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    pfam15774
    Location:321 → 470
    DUF4702; Domain of unknown function (DUF4702)

  4. XM_047427750.1 → XP_047283706.1  liprin-beta-2 isoform X2

  5. XM_006718349.4 → XP_006718412.1  liprin-beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006718412.1

    UniProtKB/TrEMBL
    A0A804HKA2
    Related
    ENSP00000507842.1, ENST00000684123.1
    Conserved Domains (7) summary
    cd09563
    Location:566 → 629
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:640 → 702
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:725 → 796
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:566 → 630
    SAM; Sterile alpha motif
    pfam01519
    Location:110 → 161
    DUF16; Protein of unknown function DUF16
    pfam15290
    Location:212 → 366
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    pfam15774
    Location:321 → 470
    DUF4702; Domain of unknown function (DUF4702)

  6. XM_011520416.4 → XP_011518718.1  liprin-beta-2 isoform X4

    Conserved Domains (7) summary
    cd09563
    Location:566 → 629
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:640 → 702
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:725 → 796
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:566 → 630
    SAM; Sterile alpha motif
    pfam01519
    Location:110 → 161
    DUF16; Protein of unknown function DUF16
    pfam15290
    Location:212 → 366
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    pfam15774
    Location:321 → 470
    DUF4702; Domain of unknown function (DUF4702)

  7. XM_005253177.4 → XP_005253234.1  liprin-beta-2 isoform X2

    Conserved Domains (6) summary
    cd09563
    Location:555 → 618
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:629 → 691
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:714 → 785
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:555 → 619
    SAM; Sterile alpha motif
    pfam01519
    Location:110 → 161
    DUF16; Protein of unknown function DUF16
    pfam15290
    Location:212 → 366
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  8. XM_011520414.3 → XP_011518716.1  liprin-beta-2 isoform X1

    See identical proteins and their annotated locations for XP_011518716.1

    UniProtKB/TrEMBL
    A0A804HKA2
    Conserved Domains (7) summary
    cd09563
    Location:566 → 629
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:640 → 702
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:725 → 796
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:566 → 630
    SAM; Sterile alpha motif
    pfam01519
    Location:110 → 161
    DUF16; Protein of unknown function DUF16
    pfam15290
    Location:212 → 366
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    pfam15774
    Location:321 → 470
    DUF4702; Domain of unknown function (DUF4702)

  9. XM_047427756.1 → XP_047283712.1  liprin-beta-2 isoform X14

  10. XM_006718352.3 → XP_006718415.1  liprin-beta-2 isoform X8

    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (6) summary
    cd09563
    Location:478 → 541
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:552 → 614
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:637 → 708
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:478 → 542
    SAM; Sterile alpha motif
    pfam01519
    Location:33 → 84
    DUF16; Protein of unknown function DUF16
    pfam15290
    Location:135 → 289
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  11. XM_024448725.2 → XP_024304493.2  liprin-beta-2 isoform X14

  12. XM_011520417.3 → XP_011518719.1  liprin-beta-2 isoform X6

    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (7) summary
    cd09563
    Location:497 → 560
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:571 → 633
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:656 → 727
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:497 → 561
    SAM; Sterile alpha motif
    pfam01519
    Location:41 → 92
    DUF16; Protein of unknown function DUF16
    pfam15290
    Location:143 → 297
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    pfam15774
    Location:252 → 401
    DUF4702; Domain of unknown function (DUF4702)

  13. XM_047427752.1 → XP_047283708.1  liprin-beta-2 isoform X7

  14. XM_011520418.3 → XP_011518720.1  liprin-beta-2 isoform X9

    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (7) summary
    cd09563
    Location:454 → 517
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:528 → 590
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:613 → 684
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:454 → 518
    SAM; Sterile alpha motif
    pfam01519
    Location:12 → 49
    DUF16; Protein of unknown function DUF16
    pfam15290
    Location:100 → 254
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    pfam15774
    Location:209 → 358
    DUF4702; Domain of unknown function (DUF4702)

  15. XM_047427753.1 → XP_047283709.1  liprin-beta-2 isoform X10

  16. XM_006718353.3 → XP_006718416.1  liprin-beta-2 isoform X11

    UniProtKB/TrEMBL
    E9PP16
    Conserved Domains (6) summary
    cd09563
    Location:423 → 486
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:497 → 559
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:582 → 653
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:423 → 487
    SAM; Sterile alpha motif
    pfam15290
    Location:69 → 223
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    pfam15774
    Location:178 → 327
    DUF4702; Domain of unknown function (DUF4702)

  17. XM_047427754.1 → XP_047283710.1  liprin-beta-2 isoform X12

  18. XM_047427755.1 → XP_047283711.1  liprin-beta-2 isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    7572359..7725720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370256.1 → XP_054226231.1  liprin-beta-2 isoform X5

  2. XM_054370254.1 → XP_054226229.1  liprin-beta-2 isoform X3

  3. XM_054370250.1 → XP_054226225.1  liprin-beta-2 isoform X1

  4. XM_054370253.1 → XP_054226228.1  liprin-beta-2 isoform X2

  5. XM_054370249.1 → XP_054226224.1  liprin-beta-2 isoform X1

  6. XM_054370255.1 → XP_054226230.1  liprin-beta-2 isoform X4

  7. XM_054370252.1 → XP_054226227.1  liprin-beta-2 isoform X2

  8. XM_054370251.1 → XP_054226226.1  liprin-beta-2 isoform X1

  9. XM_054370259.1 → XP_054226234.1  liprin-beta-2 isoform X8

  10. XM_054370257.1 → XP_054226232.1  liprin-beta-2 isoform X6

  11. XM_054370258.1 → XP_054226233.1  liprin-beta-2 isoform X7

  12. XM_054370260.1 → XP_054226235.1  liprin-beta-2 isoform X9

  13. XM_054370261.1 → XP_054226236.1  liprin-beta-2 isoform X10

  14. XM_054370262.1 → XP_054226237.1  liprin-beta-2 isoform X11

  15. XM_054370263.1 → XP_054226238.1  liprin-beta-2 isoform X12

  16. XM_054370264.1 → XP_054226239.1  liprin-beta-2 isoform X13

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8ND30.3 GenPept UniProtKB/Swiss-Prot:Q8ND30

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous