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PPFIBP1 PPFIA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 8496, updated on 3-Apr-2024

Summary

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Official Symbol
PPFIBP1provided by HGNC
Official Full Name
PPFIA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:9249
See related
Ensembl:ENSG00000110841 MIM:603141; AllianceGenome:HGNC:9249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L2; SGT2; hSGT2; hSgt2p; NEDSMBA
Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 22.3), heart (RPKM 16.3) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12p11.23-p11.22
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (27524206..27695564)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (27395877..27567299)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27677139..27848497)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix ARNT like 2 Neighboring gene BMAL2 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:27589181-27589746 Neighboring gene single-pass membrane protein with coiled-coil domains 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:27627037-27628236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:27631436-27631936 Neighboring gene arginyl-tRNA synthetase 1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:27675956-27676557 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:27677161-27677761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6146 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:27701742-27702941 Neighboring gene Sharpr-MPRA regulatory region 6326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4312 Neighboring gene chromosome 12 open reading frame 71B, pseudogene Neighboring gene MRPS35 divergent transcript Neighboring gene high mobility group box 1 pseudogene 49 Neighboring gene RAB15 effector protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel homozygous truncating variant in PPFIBP1 further delineates PPFIBP1-associated neurodevelopmental disorder. Waqas A, et al. Int J Dev Neurosci, 2023 Apr. PMID 36527195
  2. PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway. Dong C, et al. Cell Death Dis, 2021 Sep 3. PMID 34480020, Free PMC Article
  3. Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification. Takeuchi K, et al. Clin Cancer Res, 2011 May 15. PMID 21430068
  4. Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Norrmén C, et al. Blood, 2010 Jan 28. PMID 19965622, Free PMC Article
  5. Association of liprin β-1 with kank proteins in melanoma. Luo M, et al. Exp Dermatol, 2016 Apr. PMID 26739330, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel homozygous truncating variant in PPFIBP1 further delineates PPFIBP1-associated neurodevelopmental disorder.
    Title: A novel homozygous truncating variant in PPFIBP1 further delineates PPFIBP1-associated neurodevelopmental disorder.
  2. PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway.
    Title: PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway.
  3. liprin beta-1 is associated with expression of kank 1 and 2 proteins in melanoma
    Title: Association of liprin β-1 with kank proteins in melanoma.
  4. Analysis of the role of liprin-beta1 and liprin-beta2 has shown that while liprin-beta1 contributes positively to tumour cell motility in vitro; liprin-beta2 has a negative effect on both cell motility and invasion.
    Title: Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells.
  5. Liprins can mediate assembly of target proteins into large protein complexes capable of regulating numerous cellular activities.
    Title: Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures.
  6. Novel ALK fusions are being identified in various tumors in addition to inflammatory myofibroblastic tumor.
    Title: Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  8. liprin beta1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic vasculature in vivo
    Title: Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity.
  9. new molecular target of the S100A4 protein, liprin beta1
    Title: Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Neurodevelopmental disorder with seizures, microcephaly, and brain abnormalities
MedGen: C5774209 OMIM: 620024 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein, binding protein 1, beta 1 (PPFIBP1) is important for HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
liprin-beta-1
Names
PTPRF interacting protein, binding protein 1 (liprin beta 1)
PTPRF-interacting protein-binding protein 1
liprin related protein
protein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198915.2 → NP_001185844.1  liprin-beta-1 isoform 3

    See identical proteins and their annotated locations for NP_001185844.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2.
    Source sequence(s)
    AC009509, AC068794, AC087257
    Consensus CDS
    CCDS55814.1
    UniProtKB/TrEMBL
    F5GZP6
    Related
    ENSP00000445425.1, ENST00000537927.5
    Conserved Domains (5) summary
    cd09563
    Location:491 → 554
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:565 → 627
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:650 → 721
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    PTZ00108
    Location:6 → 360
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    TIGR02168
    Location:2 → 178
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001198916.2 → NP_001185845.2  liprin-beta-1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 2.
    Source sequence(s)
    AC009509, AC068794, AC087257
    Consensus CDS
    CCDS55813.1
    Related
    ENSP00000443442.1, ENST00000542629.5
    Conserved Domains (4) summary
    cd09563
    Location:613 → 676
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:687 → 749
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:772 → 843
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:103 → 311
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. NM_003622.4 → NP_003613.4  liprin-beta-1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has multiple differences in the coding sequence compared to variant 2. The resulting isoform (1) has the same N- and C-termini but is 6 aa shorter compared to isoform 2.
    Source sequence(s)
    AC009509, AC068794, AC087257
    Consensus CDS
    CCDS8713.1
    Related
    ENSP00000228425.6, ENST00000228425.11
    Conserved Domains (4) summary
    cd09563
    Location:638 → 701
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:712 → 774
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:797 → 868
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:103 → 322
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_177444.3 → NP_803193.3  liprin-beta-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC009509, AC068794, AC087257
    Consensus CDS
    CCDS55812.1
    UniProtKB/Swiss-Prot
    O75336, Q86W92, Q86X70, Q9NY03, Q9ULJ0
    Related
    ENSP00000314724.8, ENST00000318304.12
    Conserved Domains (4) summary
    cd09563
    Location:644 → 707
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:718 → 780
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:803 → 874
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:47 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    27524206..27695564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020056.3 → XP_016875545.1  liprin-beta-1 isoform X1

    Conserved Domains (4) summary
    cd09563
    Location:669 → 732
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:743 → 805
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:828 → 899
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:47 → 352
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_047429753.1 → XP_047285709.1  liprin-beta-1 isoform X14

  3. XM_047429758.1 → XP_047285714.1  liprin-beta-1 isoform X22

  4. XM_047429754.1 → XP_047285710.1  liprin-beta-1 isoform X19

  5. XM_047429760.1 → XP_047285716.1  liprin-beta-1 isoform X25

  6. XM_047429764.1 → XP_047285720.1  liprin-beta-1 isoform X29

  7. XM_047429755.1 → XP_047285711.1  liprin-beta-1 isoform X21

  8. XM_047429761.1 → XP_047285717.1  liprin-beta-1 isoform X26

  9. XM_047429765.1 → XP_047285721.1  liprin-beta-1 isoform X30

  10. XM_024449232.2 → XP_024305000.1  liprin-beta-1 isoform X1

    Conserved Domains (4) summary
    cd09563
    Location:669 → 732
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:743 → 805
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:828 → 899
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:47 → 352
    SMC_N; RecF/RecN/SMC N terminal domain

  11. XM_017020059.3 → XP_016875548.1  liprin-beta-1 isoform X5

    Conserved Domains (7) summary
    cd09563
    Location:658 → 721
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:732 → 794
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:817 → 888
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:658 → 722
    SAM; Sterile alpha motif
    pfam01519
    Location:105 → 156
    DUF16; Protein of unknown function DUF16
    pfam03528
    Location:103 → 506
    Rabaptin; Rabaptin
    cl19219
    Location:203 → 308
    DUF342; Protein of unknown function (DUF342)

  12. XM_024449234.2 → XP_024305002.1  liprin-beta-1 isoform X3

    Conserved Domains (4) summary
    cd09563
    Location:659 → 722
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:733 → 795
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:818 → 889
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:47 → 352
    SMC_N; RecF/RecN/SMC N terminal domain

  13. XM_024449237.2 → XP_024305005.1  liprin-beta-1 isoform X9

    Conserved Domains (4) summary
    cd09563
    Location:648 → 711
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:722 → 784
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:807 → 878
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:47 → 352
    SMC_N; RecF/RecN/SMC N terminal domain

  14. XM_024449233.2 → XP_024305001.1  liprin-beta-1 isoform X2

    Conserved Domains (4) summary
    cd09563
    Location:666 → 729
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:740 → 802
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:825 → 896
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:100 → 352
    SMC_N; RecF/RecN/SMC N terminal domain

  15. XM_017020061.3 → XP_016875550.1  liprin-beta-1 isoform X8

  16. XM_017020058.3 → XP_016875547.1  liprin-beta-1 isoform X6

  17. XM_047429752.1 → XP_047285708.1  liprin-beta-1 isoform X13

  18. XM_024449235.2 → XP_024305003.1  liprin-beta-1 isoform X4

    Conserved Domains (4) summary
    cd09563
    Location:658 → 721
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:732 → 794
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:817 → 888
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:47 → 341
    SMC_N; RecF/RecN/SMC N terminal domain

  19. XM_017020062.3 → XP_016875551.1  liprin-beta-1 isoform X11

    Conserved Domains (6) summary
    cd09563
    Location:647 → 710
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:721 → 783
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:806 → 877
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:647 → 711
    SAM; Sterile alpha motif
    pfam01519
    Location:105 → 156
    DUF16; Protein of unknown function DUF16
    cl19219
    Location:203 → 281
    DUF342; Protein of unknown function (DUF342)

  20. XM_047429750.1 → XP_047285706.1  liprin-beta-1 isoform X10

  21. XM_017020063.3 → XP_016875552.1  liprin-beta-1 isoform X15

  22. XM_024449236.2 → XP_024305004.1  liprin-beta-1 isoform X7

    Conserved Domains (4) summary
    cd09563
    Location:655 → 718
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:729 → 791
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:814 → 885
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:47 → 341
    SMC_N; RecF/RecN/SMC N terminal domain

  23. XM_047429751.1 → XP_047285707.1  liprin-beta-1 isoform X12

  24. XM_017020065.3 → XP_016875554.1  liprin-beta-1 isoform X17

  25. XM_017020068.3 → XP_016875557.1  liprin-beta-1 isoform X20

  26. XM_017020066.3 → XP_016875555.1  liprin-beta-1 isoform X18

  27. XM_017020071.3 → XP_016875560.1  liprin-beta-1 isoform X28

  28. XM_017020064.3 → XP_016875553.1  liprin-beta-1 isoform X16

    Conserved Domains (8) summary
    cd09563
    Location:635 → 698
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:709 → 771
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:794 → 865
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:635 → 699
    SAM; Sterile alpha motif
    pfam01519
    Location:105 → 156
    DUF16; Protein of unknown function DUF16
    pfam14662
    Location:106 → 313
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl23720
    Location:134 → 270
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23750
    Location:218 → 330
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  29. XM_017020070.3 → XP_016875559.1  liprin-beta-1 isoform X22

    Conserved Domains (8) summary
    cd09563
    Location:624 → 687
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:698 → 760
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:783 → 854
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:624 → 688
    SAM; Sterile alpha motif
    pfam01519
    Location:105 → 156
    DUF16; Protein of unknown function DUF16
    pfam14662
    Location:106 → 313
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl23720
    Location:134 → 270
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23750
    Location:218 → 330
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  30. XM_047429756.1 → XP_047285712.1  liprin-beta-1 isoform X23

  31. XM_017020073.3 → XP_016875562.1  liprin-beta-1 isoform X27

  32. XM_017020067.3 → XP_016875556.1  liprin-beta-1 isoform X19

    Conserved Domains (6) summary
    cd09563
    Location:627 → 690
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:701 → 763
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:786 → 857
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:627 → 691
    SAM; Sterile alpha motif
    pfam01519
    Location:105 → 156
    DUF16; Protein of unknown function DUF16
    cl23720
    Location:134 → 270
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  33. XM_017020072.3 → XP_016875561.1  liprin-beta-1 isoform X25

  34. XM_047429757.1 → XP_047285713.1  liprin-beta-1 isoform X24

  35. XM_047429762.1 → XP_047285718.1  liprin-beta-1 isoform X29

  36. XM_017020069.3 → XP_016875558.1  liprin-beta-1 isoform X21

    Conserved Domains (6) summary
    cd09563
    Location:624 → 687
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:698 → 760
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:783 → 854
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:624 → 688
    SAM; Sterile alpha motif
    pfam01519
    Location:105 → 156
    DUF16; Protein of unknown function DUF16
    cl23720
    Location:134 → 270
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  37. XM_047429759.1 → XP_047285715.1  liprin-beta-1 isoform X26

  38. XM_047429763.1 → XP_047285719.1  liprin-beta-1 isoform X30

  39. XM_006719159.5 → XP_006719222.1  liprin-beta-1 isoform X31

    UniProtKB/TrEMBL
    F5GZP6
    Conserved Domains (5) summary
    cd09563
    Location:516 → 579
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:590 → 652
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:675 → 746
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:516 → 580
    SAM; Sterile alpha motif
    cl19219
    Location:50 → 155
    DUF342; Protein of unknown function (DUF342)

  40. XM_024449238.2 → XP_024305006.1  liprin-beta-1 isoform X33

    Conserved Domains (1) summary
    cl25732
    Location:100 → 352
    SMC_N; RecF/RecN/SMC N terminal domain

  41. XM_017020078.2 → XP_016875567.1  liprin-beta-1 isoform X34

  42. XM_047429767.1 → XP_047285723.1  liprin-beta-1 isoform X36

  43. XM_047429768.1 → XP_047285724.1  liprin-beta-1 isoform X37

  44. XM_047429766.1 → XP_047285722.1  liprin-beta-1 isoform X35

  45. XM_017020057.3 → XP_016875546.1  liprin-beta-1 isoform X1

    Conserved Domains (4) summary
    cd09563
    Location:669 → 732
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:743 → 805
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:828 → 899
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:47 → 352
    SMC_N; RecF/RecN/SMC N terminal domain

  46. XM_017020076.3 → XP_016875565.1  liprin-beta-1 isoform X32

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    27395877..27567299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373600.1 → XP_054229575.1  liprin-beta-1 isoform X1

  2. XM_054373614.1 → XP_054229589.1  liprin-beta-1 isoform X14

  3. XM_054373627.1 → XP_054229602.1  liprin-beta-1 isoform X22

  4. XM_054373621.1 → XP_054229596.1  liprin-beta-1 isoform X19

  5. XM_054373632.1 → XP_054229607.1  liprin-beta-1 isoform X25

  6. XM_054373636.1 → XP_054229611.1  liprin-beta-1 isoform X29

  7. XM_054373624.1 → XP_054229599.1  liprin-beta-1 isoform X21

  8. XM_054373633.1 → XP_054229608.1  liprin-beta-1 isoform X26

  9. XM_054373637.1 → XP_054229612.1  liprin-beta-1 isoform X30

  10. XM_054373599.1 → XP_054229574.1  liprin-beta-1 isoform X1

  11. XM_054373605.1 → XP_054229580.1  liprin-beta-1 isoform X5

  12. XM_054373603.1 → XP_054229578.1  liprin-beta-1 isoform X3

  13. XM_054373609.1 → XP_054229584.1  liprin-beta-1 isoform X9

  14. XM_054373602.1 → XP_054229577.1  liprin-beta-1 isoform X2

  15. XM_054373608.1 → XP_054229583.1  liprin-beta-1 isoform X8

  16. XM_054373606.1 → XP_054229581.1  liprin-beta-1 isoform X6

  17. XM_054373613.1 → XP_054229588.1  liprin-beta-1 isoform X13

  18. XM_054373604.1 → XP_054229579.1  liprin-beta-1 isoform X4

  19. XM_054373611.1 → XP_054229586.1  liprin-beta-1 isoform X11

  20. XM_054373610.1 → XP_054229585.1  liprin-beta-1 isoform X10

  21. XM_054373615.1 → XP_054229590.1  liprin-beta-1 isoform X15

  22. XM_054373607.1 → XP_054229582.1  liprin-beta-1 isoform X7

  23. XM_054373612.1 → XP_054229587.1  liprin-beta-1 isoform X12

  24. XM_054373617.1 → XP_054229592.1  liprin-beta-1 isoform X17

  25. XM_054373620.1 → XP_054229595.1  liprin-beta-1 isoform X20

  26. XM_054373618.1 → XP_054229593.1  liprin-beta-1 isoform X18

  27. XM_054373631.1 → XP_054229606.1  liprin-beta-1 isoform X28

  28. XM_054373616.1 → XP_054229591.1  liprin-beta-1 isoform X16

  29. XM_054373623.1 → XP_054229598.1  liprin-beta-1 isoform X22

  30. XM_054373625.1 → XP_054229600.1  liprin-beta-1 isoform X23

  31. XM_054373630.1 → XP_054229605.1  liprin-beta-1 isoform X27

  32. XM_054373619.1 → XP_054229594.1  liprin-beta-1 isoform X19

  33. XM_054373628.1 → XP_054229603.1  liprin-beta-1 isoform X25

  34. XM_054373626.1 → XP_054229601.1  liprin-beta-1 isoform X24

  35. XM_054373634.1 → XP_054229609.1  liprin-beta-1 isoform X29

  36. XM_054373622.1 → XP_054229597.1  liprin-beta-1 isoform X21

  37. XM_054373629.1 → XP_054229604.1  liprin-beta-1 isoform X26

  38. XM_054373635.1 → XP_054229610.1  liprin-beta-1 isoform X30

  39. XM_054373638.1 → XP_054229613.1  liprin-beta-1 isoform X31

  40. XM_054373640.1 → XP_054229615.1  liprin-beta-1 isoform X33

  41. XM_054373641.1 → XP_054229616.1  liprin-beta-1 isoform X34

  42. XM_054373643.1 → XP_054229618.1  liprin-beta-1 isoform X36

  43. XM_054373644.1 → XP_054229619.1  liprin-beta-1 isoform X37

  44. XM_054373642.1 → XP_054229617.1  liprin-beta-1 isoform X35

  45. XM_054373601.1 → XP_054229576.1  liprin-beta-1 isoform X1

  46. XM_054373639.1 → XP_054229614.1  liprin-beta-1 isoform X32

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86W92.2 GenPept UniProtKB/Swiss-Prot:Q86W92

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